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CHRAC1 promotes human lung cancer growth through regulating YAP transcriptional activity.
Wang M, Li S, Guo W, Wang L, Huang J, Zhuo J, Lai B, Liao C, Ge T, Nie Y, Jin S, Wang M, Zhang Y, Liu Y, Li X, Zhang H. Wang M, et al. Carcinogenesis. 2022 Apr 25;43(3):264-276. doi: 10.1093/carcin/bgab103. Carcinogenesis. 2022. PMID: 34718437
CHRAC1 overexpression promotes lung cancer cell proliferation and migration in vitro and tumor growth in genetically engineered KrasG12D.LSL lung adenocarcinoma mouse model. Consistent with this, CHRAC1 silencing inhibits cell proliferation and migration in lung can …
CHRAC1 overexpression promotes lung cancer cell proliferation and migration in vitro and tumor growth in genetically engineered KrasG …
YY1-Induced lncRNA PART1 Enhanced Resistance of Ovarian Cancer Cells to Cisplatin by Regulating miR-512-3p/CHRAC1 Axis.
Yang H, Zhang X, Zhu L, Yang Y, Yin X. Yang H, et al. DNA Cell Biol. 2021 Jun;40(6):821-832. doi: 10.1089/dna.2021.0059. Epub 2021 May 24. DNA Cell Biol. 2021. PMID: 34030482
In addition, we screened the candidate genes of miR-512-3p., and confirmed that CHRAC1 was the downstream gene of miR-512-3p. Furthermore, the knockdown of CHRAC1 inhibited proliferation, migration, and invasion, and accelerated apoptosis of DDP-resistant OC cells, …
In addition, we screened the candidate genes of miR-512-3p., and confirmed that CHRAC1 was the downstream gene of miR-512-3p. Further …
Requirement of WDR70 for POLE3-mediated DNA double-strand breaks repair.
Mao X, Wu J, Zhang Q, Zhang S, Chen X, Liu X, Wei M, Wan X, Qiu L, Zeng M, Lei X, Liu C, Han J. Mao X, et al. Sci Adv. 2023 Sep 8;9(36):eadh2358. doi: 10.1126/sciadv.adh2358. Epub 2023 Sep 8. Sci Adv. 2023. PMID: 37682991 Free PMC article.
By using a series of biochemical and cell-based studies, we find that WDR70 promotes H2BK120ub1 by interacting with RNF20/40 complex, and deposition of H2BK120ub1 and H3K79me2 in POLE3 loci is highly sensitive to POLE3 transcription. Moreover, we demonstrate that POLE3 interacts …
By using a series of biochemical and cell-based studies, we find that WDR70 promotes H2BK120ub1 by interacting with RNF20/40 complex, and de …
The Emerging Role of Chromatin Remodeling Complexes in Ovarian Cancer.
Vaicekauskaitė I, Sabaliauskaitė R, Lazutka JR, Jarmalaitė S. Vaicekauskaitė I, et al. Int J Mol Sci. 2022 Nov 8;23(22):13670. doi: 10.3390/ijms232213670. Int J Mol Sci. 2022. PMID: 36430148 Free PMC article. Review.
Most notably, ARID1A in endometriosis-related OC, SMARCA4, and SMARCB1 in hypercalcemic type small cell ovarian carcinoma (SCCOHT), ACTL6A, CHRAC1, RSF1 amplification in high-grade serous OC. Here we review the available literature on CRCs' involvement in OC to improve our …
Most notably, ARID1A in endometriosis-related OC, SMARCA4, and SMARCB1 in hypercalcemic type small cell ovarian carcinoma (SCCOHT), ACTL6A, …
A siRNA screen identifies RAD21, EIF3H, CHRAC1 and TANC2 as driver genes within the 8q23, 8q24.3 and 17q23 amplicons in breast cancer with effects on cell growth, survival and transformation.
Mahmood SF, Gruel N, Chapeaublanc E, Lescure A, Jones T, Reyal F, Vincent-Salomon A, Raynal V, Pierron G, Perez F, Camonis J, Del Nery E, Delattre O, Radvanyi F, Bernard-Pierrot I. Mahmood SF, et al. Carcinogenesis. 2014 Mar;35(3):670-82. doi: 10.1093/carcin/bgt351. Epub 2013 Oct 22. Carcinogenesis. 2014. PMID: 24148822
Four of six other candidate driver genes-RAD21 and EIF3H, both on chromosome 8q23, CHRAC1 on chromosome 8q24.3 and TANC2 on chromosome 17q23-were confirmed to be driver genes regulating the proliferation/survival of clonogenic breast cancer cells presenting an amplificatio …
Four of six other candidate driver genes-RAD21 and EIF3H, both on chromosome 8q23, CHRAC1 on chromosome 8q24.3 and TANC2 on chromosom …
Chromatin accessibility complex subunit 1 enhances tumor growth by regulating the oncogenic transcription of YAP in breast and cervical cancer.
Li S, Wang L, Shi J, Chen Y, Xiao A, Huo B, Tian W, Zhang S, Yang G, Gong W, Zhang H. Li S, et al. PeerJ. 2024 Jan 10;12:e16752. doi: 10.7717/peerj.16752. eCollection 2024. PeerJ. 2024. PMID: 38223760 Free PMC article.
RNA-seq analysis and RT-PCR were used to analyze the transcription program change after CHRAC1 ablation. The diagnostic value of CHRAC1 was analyzed by TCGA database and further validated by immunohistochemistry staining. RESULTS: In the current study, we found that …
RNA-seq analysis and RT-PCR were used to analyze the transcription program change after CHRAC1 ablation. The diagnostic value of C …
Comparative proteomic analysis identifies differentially expressed proteins associated with meiotic arrest in cattle-yak hybrids.
Wu SX, Wan RD, Wang GW, Zhang YW, Yang QE. Wu SX, et al. Proteomics. 2023 Jun;23(12):e2300107. doi: 10.1002/pmic.202300107. Epub 2023 Apr 24. Proteomics. 2023. PMID: 37050850
The database composed of proteins associated with spermatogenesis, including KPNA2, HTATSF1, TRIP12, STIP1, LZTFL1, LARP7, MTCH2, STK31, ROMO1, CDK5AP2, DNMT1, RBM44, and CHRAC1, is the focus of further research on male hybrid sterility. ...
The database composed of proteins associated with spermatogenesis, including KPNA2, HTATSF1, TRIP12, STIP1, LZTFL1, LARP7, MTCH2, STK31, ROM …
Allelic expression imbalance polymorphisms in susceptibility chromosome regions and the risk and survival of breast cancer.
Lin W, Lin HD, Guo XY, Lin Y, Su FX, Jia WH, Tang LY, Zheng W, Long JR, Ren ZF. Lin W, et al. Mol Carcinog. 2017 Jan;56(1):300-311. doi: 10.1002/mc.22493. Epub 2016 Apr 29. Mol Carcinog. 2017. PMID: 27128794
ZNF331 rs8109631 and CHRAC1 rs10216653 were further found to represent several functional SNPs through bioinformatic analysis. In conclusion, our findings demonstrated suggestive associations of AEI polymorphisms with breast cancer risk (MUC16 rs2591592 and SLAMF1 rs106121 …
ZNF331 rs8109631 and CHRAC1 rs10216653 were further found to represent several functional SNPs through bioinformatic analysis. In con …
Analysis of the gene expression profile of mouse male meiotic germ cells.
Rossi P, Dolci S, Sette C, Capolunghi F, Pellegrini M, Loiarro M, Di Agostino S, Paronetto MP, Grimaldi P, Merico D, Martegani E, Geremia R. Rossi P, et al. Gene Expr Patterns. 2004 May;4(3):267-81. doi: 10.1016/j.modgep.2003.11.003. Gene Expr Patterns. 2004. PMID: 15053975 Free article.
Six of these were novel genes specifically expressed in pachytene spermatocytes: a chromatin remodeling factor (chrac1/YCL1), a homeobox gene (hmx1), a novel G-coupled receptor for an unknown ligand (Gpr19), a glycoprotein of the intestinal epithelium (mucin 3), a novel RA …
Six of these were novel genes specifically expressed in pachytene spermatocytes: a chromatin remodeling factor (chrac1/YCL1), a homeo …
Variable allelic expression of imprinted genes at the Peg13, Trappc9, Ago2 cluster in single neural cells.
Claxton M, Pulix M, Seah MKY, Bernardo R, Zhou P, Aljuraysi S, Liloglou T, Arnaud P, Kelsey G, Messerschmidt DM, Plagge A. Claxton M, et al. Front Cell Dev Biol. 2022 Oct 12;10:1022422. doi: 10.3389/fcell.2022.1022422. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36313557 Free PMC article.
The Peg13 imprinting cluster is associated with neurodevelopmental disorders and comprises canonical imprinted genes, which are conserved between mouse and human, as well as brain-specific imprinted genes in mouse. The latter consist of Trappc9, Chrac1 and Ago2, which have …
The Peg13 imprinting cluster is associated with neurodevelopmental disorders and comprises canonical imprinted genes, which are conserved be …
15 results