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Page 1
Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer.
Sharma S, Chung CY, Uryu S, Petrovic J, Cao J, Rickard A, Nady N, Greasley S, Johnson E, Brodsky O, Khan S, Wang H, Wang Z, Zhang Y, Tsaparikos K, Chen L, Mazurek A, Lapek J, Kung PP, Sutton S, Richardson PF, Greenwald EC, Yamazaki S, Jones R, Maegley KA, Bingham P, Lam H, Stupple AE, Kamal A, Chueh A, Cuzzupe A, Morrow BJ, Ren B, Carrasco-Pozo C, Tan CW, Bhuva DD, Allan E, Surgenor E, Vaillant F, Pehlivanoglu H, Falk H, Whittle JR, Newman J, Cursons J, Doherty JP, White KL, MacPherson L, Devlin M, Dennis ML, Hattarki MK, De Silva M, Camerino MA, Butler MS, Dolezal O, Pilling P, Foitzik R, Stupple PA, Lagiakos HR, Walker SR, Hediyeh-Zadeh S, Nuttall S, Spall SK, Charman SA, Connor T, Peat TS, Avery VM, Bozikis YE, Yang Y, Zhang M, Monahan BJ, Voss AK, Thomas T, Street IP, Dawson SJ, Dawson MA, Lindeman GJ, Davis MJ, Visvader JE, Paul TA. Sharma S, et al. Among authors: chueh a. Cell Chem Biol. 2023 Oct 19;30(10):1191-1210.e20. doi: 10.1016/j.chembiol.2023.07.005. Epub 2023 Aug 8. Cell Chem Biol. 2023. PMID: 37557181 Free article.
Feed-forward stimulation of CAMK2 by the oncogenic pseudokinase PEAK1 generates a therapeutically 'actionable' signalling axis in triple negative breast cancer.
Yang X, Ma X, Croucher DR, Nguyen EV, Clark KC, Hu C, Latham SL, Zhao T, Bayly-Jones C, Nguyen VCB, Shin SY, Nguyen LK, Cotton TR, Chüeh AC, Kam Sian TCCL, Stratton MM, Ellisdon AM, Daly RJ. Yang X, et al. Among authors: chueh ac. bioRxiv [Preprint]. 2024 Feb 15:2024.02.14.580406. doi: 10.1101/2024.02.14.580406. bioRxiv. 2024. PMID: 38405732 Free PMC article. Preprint.
Pediatric glioma histone H3.3 K27M/G34R mutations drive abnormalities in PML nuclear bodies.
Voon HPJ, Hii L, Garvie A, Udugama M, Krug B, Russo C, Chüeh AC, Daly RJ, Morey A, Bell TDM, Turner SJ, Rosenbluh J, Daniel P, Firestein R, Mann JR, Collas P, Jabado N, Wong LH. Voon HPJ, et al. Among authors: chueh ac. Genome Biol. 2023 Dec 8;24(1):284. doi: 10.1186/s13059-023-03122-5. Genome Biol. 2023. PMID: 38066546 Free PMC article.
Correction: ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors Across Tumor Types.
Chüeh AC, Tse JWT, Dickinson M, Ioannidis P, Jenkins L, Togel L, Tan B, Luk I, Davalos-Salas M, Nightingale R, Thompson MR, Williams BRG, Lessene G, Lee EF, Fairlie WD, Dhillon AS, Mariadason JM. Chüeh AC, et al. Clin Cancer Res. 2023 Sep 15;29(18):3826. doi: 10.1158/1078-0432.CCR-23-2100. Clin Cancer Res. 2023. PMID: 37712140 No abstract available.
Author Correction: DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.
Tögel L, Nightingale R, Wu R, Chüeh AC, Al-Obaidi S, Luk I, Dávalos-Salas M, Chionh F, Murone C, Buchanan DD, Chatterton Z, Sieber OM, Arango D, Tebbutt NC, Williams D, Dhillon AS, Mariadason JM. Tögel L, et al. Among authors: chueh ac. Sci Rep. 2023 Feb 10;13(1):2422. doi: 10.1038/s41598-023-29328-y. Sci Rep. 2023. PMID: 36765160 Free PMC article. No abstract available.
VEGF-A, VEGFR1 and VEGFR2 single nucleotide polymorphisms and outcomes from the AGITG MAX trial of capecitabine, bevacizumab and mitomycin C in metastatic colorectal cancer.
Chionh F, Gebski V, Al-Obaidi SJ, Mooi JK, Bruhn MA, Lee CK, Chüeh AC, Williams DS, Weickhardt AJ, Wilson K, Scott AM, Simes J, Hardingham JE, Price TJ, Mariadason JM, Tebbutt NC. Chionh F, et al. Among authors: chueh ac. Sci Rep. 2022 Jan 24;12(1):1238. doi: 10.1038/s41598-021-03952-y. Sci Rep. 2022. PMID: 35075138 Free PMC article. Clinical Trial.
CSK-homologous kinase (CHK/MATK) is a potential colorectal cancer tumour suppressor gene epigenetically silenced by promoter methylation.
Chüeh AC, Advani G, Foroutan M, Smith J, Ng N, Nandurkar H, Lio DS, Zhu HJ, Chong YP, Verkade H, Fujita DJ, Bjorge J, Basheer F, Lim JP, Luk I, Dhillon A, Sakthianandeswaren A, Mouradov D, Sieber O, Hollande F, Mariadason JM, Cheng HC. Chüeh AC, et al. Oncogene. 2021 Apr;40(17):3015-3029. doi: 10.1038/s41388-021-01755-z. Epub 2021 Mar 25. Oncogene. 2021. PMID: 33767439
Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors.
Grohmann C, Walker F, Devlin M, Luo MX, Chüeh AC, Doherty J, Vaillant F, Ho GY, Wakefield MJ, Weeden CE, Kamili A, Murray J, Po'uha ST, Weinstock J, Kane SR, Faux MC, Broekhuizen E, Zheng Y, Shield-Artin K, Kershaw NJ, Tan CW, Witchard HM, Ebert G, Charman SA, Street I, Kavallaris M, Haber M, Fletcher JI, Asselin-Labat ML, Scott CL, Visvader JE, Lindeman GJ, Watson KG, Burgess AW, Lessene G. Grohmann C, et al. Among authors: chueh ac. Cell Death Dis. 2021 Mar 12;12(3):268. doi: 10.1038/s41419-020-03269-0. Cell Death Dis. 2021. PMID: 33712556 Free PMC article.
31 results