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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1972 1
1974 1
1978 1
1989 2
1990 2
1995 7
1996 4
1997 14
1998 32
1999 89
2000 113
2001 146
2002 148
2003 197
2004 238
2005 141
2006 26
2007 25
2008 45
2009 24
2010 44
2011 28
2012 34
2013 38
2014 41
2015 44
2016 41
2017 43
2018 58
2019 54
2020 58
2021 64
2022 47
2023 38
2024 16

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1,771 results

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Page 1
Attribution of NF-kappaB Activity to CHUK/IKKalpha-Involved Carcinogenesis.
Li X, Hu Y. Li X, et al. Cancers (Basel). 2021 Mar 19;13(6):1411. doi: 10.3390/cancers13061411. Cancers (Basel). 2021. PMID: 33808757 Free PMC article. Review.
Inhibitor-kappaB kinase alpha (IKKalpha), which is encoded by the conserved helix-loop-helix ubiquitous kinase (CHUK) gene, is first identified as a serine/threonine protein kinase in the inhibitor-kappaB kinase complex (IKK), which is composed of IKKalpha, IKKbeta, and IK …
Inhibitor-kappaB kinase alpha (IKKalpha), which is encoded by the conserved helix-loop-helix ubiquitous kinase (CHUK) gene, is first …
NF-kappaB regulation in the immune system.
Li Q, Verma IM. Li Q, et al. Nat Rev Immunol. 2002 Oct;2(10):725-34. doi: 10.1038/nri910. Nat Rev Immunol. 2002. PMID: 12360211 Review.
Association of CHUK gene polymorphism and ischemic stroke in the Han Chinese population.
Huang J, Wei Q, Liang B, Shen T, Wu Y, Chen Z, Yang J, Gu L. Huang J, et al. J Clin Neurosci. 2021 Jun;88:271-276. doi: 10.1016/j.jocn.2021.04.009. Epub 2021 Apr 23. J Clin Neurosci. 2021. PMID: 33992196
However, the association between CHUK and IS has not yet been explored. This study aims at evaluating the relationship of CHUK polymorphisms (rs3808916, rs2230804 and rs3808917) and IS risk as well as IS-related risk factors. ...CONCLUSIONS: The CHUK expressi …
However, the association between CHUK and IS has not yet been explored. This study aims at evaluating the relationship of CHUK …
CHUK/IKK-alpha loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulation.
Chavdoula E, Habiel DM, Roupakia E, Markopoulos GS, Vasilaki E, Kokkalis A, Polyzos AP, Boleti H, Thanos D, Klinakis A, Kolettas E, Marcu KB. Chavdoula E, et al. Life Sci Alliance. 2019 Dec 2;2(6):e201900460. doi: 10.26508/lsa.201900460. Print 2019 Dec. Life Sci Alliance. 2019. PMID: 31792060 Free PMC article.
Herein, we show two independent in vivo lung cancer models in which CHUK/IKK-alpha acts as a major NSCLC tumor suppressor. In a novel transgenic mouse strain, wherein IKKalpha ablation is induced by tamoxifen (Tmx) solely in alveolar type II (AT-II) lung epithelial cells, …
Herein, we show two independent in vivo lung cancer models in which CHUK/IKK-alpha acts as a major NSCLC tumor suppressor. In a novel …
MiRNA-223-3p Affects Mantle Cell Lymphoma Development by Regulating the CHUK/NF-KB2 Signaling Pathway.
Yuan J, Zhang Q, Wu S, Yan S, Zhao R, Sun Y, Tian X, Zhou K. Yuan J, et al. Onco Targets Ther. 2021 Mar 2;14:1553-1564. doi: 10.2147/OTT.S283486. eCollection 2021. Onco Targets Ther. 2021. PMID: 33688203 Free PMC article.
Dual-luciferase reporter assay was used to verify the inhibitory effect of miRNA-223-3p on CHUK. Furthermore, the regulatory function of miRNA-223-3p on the CHUK/NF-KB2 axis was assessed by RT-qPCR, western blot and immunofluorescence. ...Importantly, CHUK ov …
Dual-luciferase reporter assay was used to verify the inhibitory effect of miRNA-223-3p on CHUK. Furthermore, the regulatory function …
CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19.
Mock BA, Connelly MA, McBride OW, Kozak CA, Marcu KB. Mock BA, et al. Genomics. 1995 May 20;27(2):348-51. doi: 10.1006/geno.1995.1054. Genomics. 1995. PMID: 7558004
Helix-loop-helix proteins contain stretches of DNA that encode two amphipathic alpha-helices joined by a loop structure and are involved in protein dimerization and transcriptional regulation essential to a variety of cellular processes. CHUK, a newly described conserved h …
Helix-loop-helix proteins contain stretches of DNA that encode two amphipathic alpha-helices joined by a loop structure and are involved in …
The times, they are a changing-Still.
Fielding R. Fielding R. Psychooncology. 2022 Apr;31(4):555. doi: 10.1002/pon.5930. Psychooncology. 2022. PMID: 35396896 No abstract available.
miRNA-223-3p modulates ibrutinib resistance through regulation of the CHUK/Nf-kappab signaling pathway in mantle cell lymphoma.
Yuan J, Zhang Q, Wu S, Yan S, Zhao R, Sun Y, Tian X, Zhou K. Yuan J, et al. Exp Hematol. 2021 Nov;103:52-59.e2. doi: 10.1016/j.exphem.2021.08.010. Epub 2021 Aug 30. Exp Hematol. 2021. PMID: 34474146 Free article.
In the present study, conserved helix-loop-helix ubiquitous kinase (CHUK) overexpression accelerated proliferation and suppressed apoptosis of MCL cells after ibrutinib treatment in vitro. ...In conclusion, miRNA-223-3p modulates ibrutinib resistance through regulation of …
In the present study, conserved helix-loop-helix ubiquitous kinase (CHUK) overexpression accelerated proliferation and suppressed apo …
Mutant CHUK and severe fetal encasement malformation.
Lahtela J, Nousiainen HO, Stefanovic V, Tallila J, Viskari H, Karikoski R, Gentile M, Saloranta C, Varilo T, Salonen R, Kestilä M. Lahtela J, et al. N Engl J Med. 2010 Oct 21;363(17):1631-7. doi: 10.1056/NEJMoa0911698. N Engl J Med. 2010. PMID: 20961246 Free article.
A point mutation in two affected fetuses led to the loss of the conserved helix-loop-helix ubiquitous kinase (CHUK), also known as IkappaB kinase alpha. CHUK has an essential role in the development of skin epidermis and its derivatives, along with various other mor …
A point mutation in two affected fetuses led to the loss of the conserved helix-loop-helix ubiquitous kinase (CHUK), also known as Ik …
1,771 results