Clark P - Search Results

1

Two Coselected Distal Mutations in HIV-1 Reverse Transcriptase (RT) Alter Susceptibility to Nonnucleoside RT Inhibitors and Nucleoside Analogs.

Boyer PL, Melody K, Smith SJ, Dunn LL, Kline C, Fischer DK, Dwivedi R, Clark P, Hughes SH, Ambrose Z. Boyer PL, et al. Among authors: clark p. J Virol. 2019 May 15;93(11):e00224-19. doi: 10.1128/JVI.00224-19. Print 2019 Jun 1. J Virol. 2019. PMID: 30894467 Free PMC article.

2

Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase.

Boyer PL, Stenbak CR, Clark PK, Linial ML, Hughes SH. Boyer PL, et al. J Virol. 2004 Jun;78(12):6112-21. doi: 10.1128/JVI.78.12.6112-6121.2004. J Virol. 2004. PMID: 15163704 Free PMC article.

3

HIV-1 and HIV-2 reverse transcriptases: different mechanisms of resistance to nucleoside reverse transcriptase inhibitors.

Boyer PL, Clark PK, Hughes SH. Boyer PL, et al. J Virol. 2012 May;86(10):5885-94. doi: 10.1128/JVI.06597-11. Epub 2012 Mar 21. J Virol. 2012. PMID: 22438533 Free PMC article.

4

Mutations in HIV-1 reverse transcriptase cause misfolding and miscleavage by the viral protease.

Dunn LL, Boyer PL, Clark PK, Hughes SH. Dunn LL, et al. Virology. 2013 Sep;444(1-2):241-9. doi: 10.1016/j.virol.2013.06.017. Epub 2013 Jul 11. Virology. 2013. PMID: 23850459 Free PMC article.

5

A Combination of Amino Acid Mutations Leads to Resistance to Multiple Nucleoside Analogs in Reverse Transcriptases from HIV-1 Subtypes B and C.

Boyer PL, Rehm CA, Sneller MC, Mican J, Caplan MR, Dewar R, Ferris AL, Clark P, Johnson A, Maldarelli F, Hughes SH. Boyer PL, et al. Among authors: clark p. Antimicrob Agents Chemother. 2022 Jan 18;66(1):e0150021. doi: 10.1128/AAC.01500-21. Epub 2021 Nov 1. Antimicrob Agents Chemother. 2022. PMID: 34723625 Free PMC article.

6

The basic loop of the RNase H domain of MLV RT is important both for RNase H and for polymerase activity.

Boyer PL, Gao HQ, Frank P, Clark PK, Hughes SH. Boyer PL, et al. Among authors: clark pk. Virology. 2001 Mar 30;282(1):206-13. doi: 10.1006/viro.2000.0827. Virology. 2001. PMID: 11259203 Free article.

7

YADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro.

Boyer PL, Gao HQ, Clark PK, Sarafianos SG, Arnold E, Hughes SH. Boyer PL, et al. Among authors: clark pk. J Virol. 2001 Jul;75(14):6321-8. doi: 10.1128/JVI.75.14.6321-6328.2001. J Virol. 2001. PMID: 11413298 Free PMC article.

8

Cross-linking of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase to template-primer.

Peletskaya EN, Boyer PL, Kogon AA, Clark P, Kroth H, Sayer JM, Jerina DM, Hughes SH. Peletskaya EN, et al. Among authors: clark p. J Virol. 2001 Oct;75(19):9435-45. doi: 10.1128/JVI.75.19.9435-9445.2001. J Virol. 2001. PMID: 11533206 Free PMC article.

9

Why do HIV-1 and HIV-2 use different pathways to develop AZT resistance?

Boyer PL, Sarafianos SG, Clark PK, Arnold E, Hughes SH. Boyer PL, et al. PLoS Pathog. 2006 Feb;2(2):e10. doi: 10.1371/journal.ppat.0020010. Epub 2006 Feb 17. PLoS Pathog. 2006. PMID: 16485036 Free PMC article.

10

Foamy retrovirus integrase contains a Pol dimerization domain required for protease activation.

Lee EG, Roy J, Jackson D, Clark P, Boyer PL, Hughes SH, Linial ML. Lee EG, et al. Among authors: clark p. J Virol. 2011 Feb;85(4):1655-61. doi: 10.1128/JVI.01873-09. Epub 2010 Dec 1. J Virol. 2011. PMID: 21123385 Free PMC article.

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