Clarke AR - Search Results

1

TGFβ inhibition restores a regenerative response in acute liver injury by suppressing paracrine senescence.

Bird TG, Müller M, Boulter L, Vincent DF, Ridgway RA, Lopez-Guadamillas E, Lu WY, Jamieson T, Govaere O, Campbell AD, Ferreira-Gonzalez S, Cole AM, Hay T, Simpson KJ, Clark W, Hedley A, Clarke M, Gentaz P, Nixon C, Bryce S, Kiourtis C, Sprangers J, Nibbs RJB, Van Rooijen N, Bartholin L, McGreal SR, Apte U, Barry ST, Iredale JP, Clarke AR, Serrano M, Roskams TA, Sansom OJ, Forbes SJ. Bird TG, et al. Among authors: clarke ar, clarke m. Sci Transl Med. 2018 Aug 15;10(454):eaan1230. doi: 10.1126/scitranslmed.aan1230. Sci Transl Med. 2018. PMID: 30111642 Free PMC article.

2

Hepatic progenitor cells of biliary origin with liver repopulation capacity.

Lu WY, Bird TG, Boulter L, Tsuchiya A, Cole AM, Hay T, Guest RV, Wojtacha D, Man TY, Mackinnon A, Ridgway RA, Kendall T, Williams MJ, Jamieson T, Raven A, Hay DC, Iredale JP, Clarke AR, Sansom OJ, Forbes SJ. Lu WY, et al. Among authors: clarke ar. Nat Cell Biol. 2015 Aug;17(8):971-983. doi: 10.1038/ncb3203. Epub 2015 Jul 20. Nat Cell Biol. 2015. PMID: 26192438 Free PMC article.

3

Mutations in Apc and p53 synergize to promote mammary neoplasia.

Méniel V, Hay T, Douglas-Jones A, Sansom OJ, Clarke AR. Méniel V, et al. Among authors: clarke ar. Cancer Res. 2005 Jan 15;65(2):410-6. Cancer Res. 2005. PMID: 15695381

4

p21 loss blocks senescence following Apc loss and provokes tumourigenesis in the renal but not the intestinal epithelium.

Cole AM, Ridgway RA, Derkits SE, Parry L, Barker N, Clevers H, Clarke AR, Sansom OJ. Cole AM, et al. Among authors: clarke ar. EMBO Mol Med. 2010 Nov;2(11):472-86. doi: 10.1002/emmm.201000101. EMBO Mol Med. 2010. PMID: 20976827 Free PMC article.

5

B-catenin deficiency, but not Myc deletion, suppresses the immediate phenotypes of APC loss in the liver.

Reed KR, Athineos D, Meniel VS, Wilkins JA, Ridgway RA, Burke ZD, Muncan V, Clarke AR, Sansom OJ. Reed KR, et al. Among authors: clarke ar. Proc Natl Acad Sci U S A. 2008 Dec 2;105(48):18919-23. doi: 10.1073/pnas.0805778105. Epub 2008 Nov 24. Proc Natl Acad Sci U S A. 2008. PMID: 19033191 Free PMC article.

6

Cyclin D2-cyclin-dependent kinase 4/6 is required for efficient proliferation and tumorigenesis following Apc loss.

Cole AM, Myant K, Reed KR, Ridgway RA, Athineos D, Van den Brink GR, Muncan V, Clevers H, Clarke AR, Sicinski P, Sansom OJ. Cole AM, et al. Among authors: clarke ar. Cancer Res. 2010 Oct 15;70(20):8149-58. doi: 10.1158/0008-5472.CAN-10-0315. Epub 2010 Aug 24. Cancer Res. 2010. PMID: 20736363 Free PMC article.

7

The ability to engage enterocyte apoptosis does not predict long-term crypt survival in p53 and Msh2 deficient mice.

Sansom OJ, Clarke AR. Sansom OJ, et al. Among authors: clarke ar. Oncogene. 2002 Aug 29;21(38):5934-9. doi: 10.1038/sj.onc.1205760. Oncogene. 2002. PMID: 12185594

8

Analyzing tumor suppressor activities in the murine small intestine.

Clarke AR, Sansom OJ. Clarke AR, et al. Oncol Res. 2003;13(6-10):333-7. doi: 10.3727/096504003108748537. Oncol Res. 2003. PMID: 12725522 Review.

9

Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer.

Sansom OJ, Maddison K, Clarke AR. Sansom OJ, et al. Among authors: clarke ar. Nat Clin Pract Oncol. 2007 May;4(5):305-15. doi: 10.1038/ncponc0812. Nat Clin Pract Oncol. 2007. PMID: 17464338 Review.

10

Absolute requirement for STAT3 function in small-intestine crypt stem cell survival.

Matthews JR, Sansom OJ, Clarke AR. Matthews JR, et al. Among authors: clarke ar. Cell Death Differ. 2011 Dec;18(12):1934-43. doi: 10.1038/cdd.2011.77. Epub 2011 Jun 3. Cell Death Differ. 2011. PMID: 21637293 Free PMC article.

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