Clausen RP - Search Results

1

Selective GABA transporter inhibitors tiagabine and EF1502 exhibit mechanistic differences in their ability to modulate the ataxia and anticonvulsant action of the extrasynaptic GABA(A) receptor agonist gaboxadol.

Madsen KK, Ebert B, Clausen RP, Krogsgaard-Larsen P, Schousboe A, White HS. Madsen KK, et al. Among authors: clausen rp. J Pharmacol Exp Ther. 2011 Jul;338(1):214-9. doi: 10.1124/jpet.111.179671. Epub 2011 Mar 30. J Pharmacol Exp Ther. 2011. PMID: 21450931 Free PMC article.

2

Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.

Clausen RP, Bräuner-Osborne H, Greenwood JR, Hermit MB, Stensbøl TB, Nielsen B, Krogsgaard-Larsen P. Clausen RP, et al. J Med Chem. 2002 Sep 12;45(19):4240-5. doi: 10.1021/jm020122x. J Med Chem. 2002. PMID: 12213064

3

A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.

Vogensen SB, Greenwood JR, Varming AR, Brehm L, Pickering DS, Nielsen B, Liljefors T, Clausen RP, Johansen TN, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: clausen rp. Org Biomol Chem. 2004 Jan 21;2(2):206-13. doi: 10.1039/b310450h. Epub 2003 Nov 24. Org Biomol Chem. 2004. PMID: 14737644

4

First demonstration of a functional role for central nervous system betaine/{gamma}-aminobutyric acid transporter (mGAT2) based on synergistic anticonvulsant action among inhibitors of mGAT1 and mGAT2.

White HS, Watson WP, Hansen SL, Slough S, Perregaard J, Sarup A, Bolvig T, Petersen G, Larsson OM, Clausen RP, Frølund B, Falch E, Krogsgaard-Larsen P, Schousboe A. White HS, et al. Among authors: clausen rp. J Pharmacol Exp Ther. 2005 Feb;312(2):866-74. doi: 10.1124/jpet.104.068825. Epub 2004 Nov 18. J Pharmacol Exp Ther. 2005. PMID: 15550575

5

Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues.

Clausen RP, Moltzen EK, Perregaard J, Lenz SM, Sanchez C, Falch E, Frølund B, Bolvig T, Sarup A, Larsson OM, Schousboe A, Krogsgaard-Larsen P. Clausen RP, et al. Bioorg Med Chem. 2005 Feb 1;13(3):895-908. doi: 10.1016/j.bmc.2004.10.029. Bioorg Med Chem. 2005. PMID: 15653355

6

Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.

Vogensen SB, Clausen RP, Greenwood JR, Johansen TN, Pickering DS, Nielsen B, Ebert B, Krogsgaard-Larsen P. Vogensen SB, et al. Among authors: clausen rp. J Med Chem. 2005 May 5;48(9):3438-42. doi: 10.1021/jm050014l. J Med Chem. 2005. PMID: 15857151

7

Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain.

Wellendorph P, Høg S, Greenwood JR, de Lichtenberg A, Nielsen B, Frølund B, Brehm L, Clausen RP, Bräuner-Osborne H. Wellendorph P, et al. Among authors: clausen rp. J Pharmacol Exp Ther. 2005 Oct;315(1):346-51. doi: 10.1124/jpet.105.090472. Epub 2005 Jul 12. J Pharmacol Exp Ther. 2005. PMID: 16014570

8

A novel selective gamma-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS.

Clausen RP, Frølund B, Larsson OM, Schousboe A, Krogsgaard-Larsen P, White HS. Clausen RP, et al. Neurochem Int. 2006 May-Jun;48(6-7):637-42. doi: 10.1016/j.neuint.2005.12.031. Epub 2006 Mar 3. Neurochem Int. 2006. PMID: 16517017 Review.

9

Structure-activity relationships of selective GABA uptake inhibitors.

Høg S, Greenwood JR, Madsen KB, Larsson OM, Frølund B, Schousboe A, Krogsgaard-Larsen P, Clausen RP. Høg S, et al. Among authors: clausen rp. Curr Top Med Chem. 2006;6(17):1861-82. doi: 10.2174/156802606778249801. Curr Top Med Chem. 2006. PMID: 17017962 Review.

10

Structure-activity relationship and pharmacology of gamma-aminobutyric acid (GABA) transport inhibitors.

Clausen RP, Madsen K, Larsson OM, Frølund B, Krogsgaard-Larsen P, Schousboe A. Clausen RP, et al. Adv Pharmacol. 2006;54:265-84. doi: 10.1016/s1054-3589(06)54011-6. Adv Pharmacol. 2006. PMID: 17175818 Review. No abstract available.

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