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Co-expression of sperm membrane proteins CMTM2A and CMTM2B is essential for ADAM3 localization and male fertility in mice.
Fujihara Y, Oji A, Kojima-Kita K, Larasati T, Ikawa M. Fujihara Y, et al. J Cell Sci. 2018 Oct 8;131(19):jcs221481. doi: 10.1242/jcs.221481. J Cell Sci. 2018. PMID: 30209135 Free PMC article.
In this study, we focused on the testis-specific mouse CMTM gene cluster (Cmtm1, Cmtm2a and Cmtm2b) and generated CRISPR/Cas9-mediated mutant mice to examine their physiological functions. Although Cmtm1 mutant mice were fertile, Cmtm2a and Cmtm2b double mutant mice …
In this study, we focused on the testis-specific mouse CMTM gene cluster (Cmtm1, Cmtm2a and Cmtm2b) and generated CRISPR/Cas9-mediate …
CRISPR/Cas9-mediated disruption of lipocalins, Ly6g5b, and Ly6g5c causes male subfertility in mice.
Sakurai N, Fujihara Y, Kobayashi K, Ikawa M. Sakurai N, et al. Andrology. 2022 Nov 25:10.1111/andr.13350. doi: 10.1111/andr.13350. Online ahead of print. Andrology. 2022. PMID: 36428102 Free PMC article.
Further analysis revealed that the quintuple KO spermatozoa lack the CMTM2A/B that are required for ADAM3 maturation. Intriguingly, Ly6g5b and Ly6g5c double KO male mice also showed subfertility with reduced sperm ADAM3. ...
Further analysis revealed that the quintuple KO spermatozoa lack the CMTM2A/B that are required for ADAM3 maturation. Intriguingly, L …
The expression of CKLFSF2B is regulated by GATA1 and CREB in the Leydig cells, which modulates testicular steroidogenesis.
Kumar S, Kang H, Park E, Park HS, Lee K. Kumar S, et al. Biochim Biophys Acta Gene Regul Mech. 2018 Dec;1861(12):1063-1075. doi: 10.1016/j.bbagrm.2018.10.002. Epub 2018 Oct 12. Biochim Biophys Acta Gene Regul Mech. 2018. PMID: 30321752
In the course of evolution, CKLFSF2 has evolved as two isoforms, namely CKLFSF2A and CKLFSF2B, in mice. CKLFSF2A, also known as CMTM2A and ARR19, is expressed in the testis and is important for testicular steroidogenesis. ...
In the course of evolution, CKLFSF2 has evolved as two isoforms, namely CKLFSF2A and CKLFSF2B, in mice. CKLFSF2A, also known as CMTM2A …