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Year Number of Results
1996 1
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2004 1
2005 1
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2009 1
2011 2
2012 1
2013 4
2014 2
2015 2
2016 5
2017 6
2018 2
2019 11
2020 6
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Page 1
CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells.
Sohn EJ, Jung DB, Lee H, Han I, Lee J, Lee H, Kim SH. Sohn EJ, et al. Cancer Lett. 2018 Jan 1;412:88-98. doi: 10.1016/j.canlet.2017.09.052. Epub 2017 Oct 9. Cancer Lett. 2018. PMID: 29024811
Also, CNOT2 depletion suppressed proliferation and colony formation of MDA-MB-231 cells. ...Consistently, downregulation of VEGF, CNOT2 and HIF2 alpha was verified in CNOT2 depleted MDA-MB-231 cells by RT-qPCR. ...
Also, CNOT2 depletion suppressed proliferation and colony formation of MDA-MB-231 cells. ...Consistently, downregulation of VEGF, …
CNOT2 facilitates dengue virus infection via negatively modulating IFN-Independent Non-Canonical JAK/STAT pathway.
Liu J, Yang L, Liu F, Li H, Tang W, Tong X, Zuo J. Liu J, et al. Biochem Biophys Res Commun. 2019 Jul 30;515(3):403-409. doi: 10.1016/j.bbrc.2019.05.083. Epub 2019 May 31. Biochem Biophys Res Commun. 2019. PMID: 31155293
In this study, Ccr4-Not complex genes were screened by using RNAi approach in DENV-infected A549 and Huh7 cells. We found that CNOT2 plays a proviral role in DENV infection. The expression level of CNOT2 was up-regulated in DENV-infected cells. Down-regulation of …
In this study, Ccr4-Not complex genes were screened by using RNAi approach in DENV-infected A549 and Huh7 cells. We found that CNOT2 …
A heterozygous, intragenic deletion of CNOT2 recapitulates the phenotype of 12q15 deletion syndrome.
Alesi V, Loddo S, Calì F, Orlando V, Genovese S, Ferretti D, Calacci C, Calvieri G, Falasca R, Ulgheri L, Drago F, Dallapiccola B, Baban A, Novelli A. Alesi V, et al. Am J Med Genet A. 2019 Aug;179(8):1615-1621. doi: 10.1002/ajmg.a.61217. Epub 2019 May 30. Am J Med Genet A. 2019. PMID: 31145527 Review.
The smallest region of overlap for this syndrome was included in a genomic segment spanning CNOT2, KCNMB4, and PTPRB genes. We report on an additional patient harboring a 12q15 microdeletion encompassing only part of CNOT2 gene, presenting with a spectrum of clinica …
The smallest region of overlap for this syndrome was included in a genomic segment spanning CNOT2, KCNMB4, and PTPRB genes. We report …
Inhibition of CNOT2 Induces Apoptosis via MID1IP1 in Colorectal Cancer Cells by Activating p53.
Jung JH, Lee D, Ko HM, Jang HJ. Jung JH, et al. Biomolecules. 2021 Oct 10;11(10):1492. doi: 10.3390/biom11101492. Biomolecules. 2021. PMID: 34680125 Free PMC article.
Inhibition of CNOT2 markedly induced apoptosis in various cancer cells like that of the wild-type p53. Furthermore, inhibition of CNOT2 elongated p53 s half-life. Previously, our laboratory demonstrated that MID1IP1 promoted colocalization with c-Myc mediated by …
Inhibition of CNOT2 markedly induced apoptosis in various cancer cells like that of the wild-type p53. Furthermore, inhibition of …
CNOT2 promotes degradation of p62/SQSTM1 as a negative regulator in ATG5 dependent autophagy.
Jeong K, Kwon HY, Jeong MS, Sohn EJ, Kim SH. Jeong K, et al. Oncotarget. 2017 Jul 11;8(28):46034-46046. doi: 10.18632/oncotarget.17682. Oncotarget. 2017. PMID: 28537904 Free PMC article.
Though CNOT2 is involved in regulation of adipogenic differentiation, apoptotic cell death and metastasis, the underlying autophagic mechanism of CNOT2 was unknown until now. ...Additionally, ATG5 was upregulated in CNOT2-depleted H1299 cells, while degradati …
Though CNOT2 is involved in regulation of adipogenic differentiation, apoptotic cell death and metastasis, the underlying autophagic …
CNOT2 as the critical gene for phenotypes of 12q15 microdeletion syndrome.
Uehara T, Takenouchi T, Yamaguchi Y, Daimon Y, Suzuki H, Sakaguchi Y, Kosaki K. Uehara T, et al. Am J Med Genet A. 2019 Apr;179(4):659-662. doi: 10.1002/ajmg.a.61068. Epub 2019 Feb 15. Am J Med Genet A. 2019. PMID: 30768759
A microarray analysis showed a de novo 1.32-Mb deletion within 12q15 that included CNOT2 and 14 other genes. Remapping of the 12q15 deletion region in the 16 previously reported patients together with that in the newly identified patient indicated that CNOT2 is the …
A microarray analysis showed a de novo 1.32-Mb deletion within 12q15 that included CNOT2 and 14 other genes. Remapping of the 12q15 d …
Regulation of CCR4-NOT complex deadenylase activity and cellular responses by MK2-dependent phosphorylation of CNOT2.
Suzuki T, Hoshina M, Nishijima S, Hoshina N, Kikuguchi C, Tomohiro T, Fukao A, Fujiwara T, Yamamoto T. Suzuki T, et al. RNA Biol. 2022;19(1):234-246. doi: 10.1080/15476286.2021.2021676. Epub 2021 Dec 31. RNA Biol. 2022. PMID: 35129087 Free PMC article.
Here, we show that osmotic stress induces MAPKAPK-2 (MK2)-mediated phosphorylation of CNOT2. Programmed cell death is greatly enhanced by osmotic stress in CNOT2-depleted cells, indicating that CNOT2 is responsible for stress resistance of cells. ...Consisten …
Here, we show that osmotic stress induces MAPKAPK-2 (MK2)-mediated phosphorylation of CNOT2. Programmed cell death is greatly enhance …
Delineation of the clinical profile of CNOT2 haploinsufficiency and overview of the IDNADFS phenotype.
Niceta M, Pizzi S, Inzana F, Peron A, Bakhtiari S, Nizon M, Levy J, Mancini C, Cogné B, Radio FC, Agolini E, Cocciadiferro D, Novelli A, Salih MA, Recalcati MP, Arancio R, Besnard M, Tabet AC, Kruer MC, Priolo M, Dallapiccola B, Tartaglia M. Niceta M, et al. Clin Genet. 2023 Feb;103(2):156-166. doi: 10.1111/cge.14247. Epub 2022 Nov 24. Clin Genet. 2023. PMID: 36224108 Free PMC article.
The condition clinically overlaps with chromosome 12q15 deletion syndrome, suggesting a major contribution of CNOT2 haploinsufficiency to the latter. CNOT2 is a member of the CCR4-NOT complex, which is a master regulator of multiple cellular processes, including gen …
The condition clinically overlaps with chromosome 12q15 deletion syndrome, suggesting a major contribution of CNOT2 haploinsufficienc …
60 results