Coffey NJ - Search Results

1

Synthesis of ¹³ C₆ -labeled, dual-target inhibitor of cannabinoid-1 receptor (CB₁ R) and inducible nitric oxide synthase (iNOS).

Iyer MR, Cinar R, Coffey NJ, Kunos G. Iyer MR, et al. Among authors: coffey nj. J Labelled Comp Radiopharm. 2018 May 23. doi: 10.1002/jlcr.3639. Online ahead of print. J Labelled Comp Radiopharm. 2018. PMID: 29790591

2

Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB₁R Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis.

Iyer MR, Cinar R, Katz A, Gao M, Erdelyi K, Jourdan T, Coffey NJ, Pacher P, Kunos G. Iyer MR, et al. Among authors: coffey nj. J Med Chem. 2017 Feb 9;60(3):1126-1141. doi: 10.1021/acs.jmedchem.6b01504. Epub 2017 Jan 27. J Med Chem. 2017. PMID: 28085283

3

Cannabinoid CB1 receptor overactivity contributes to the pathogenesis of idiopathic pulmonary fibrosis.

Cinar R, Gochuico BR, Iyer MR, Jourdan T, Yokoyama T, Park JK, Coffey NJ, Pri-Chen H, Szanda G, Liu Z, Mackie K, Gahl WA, Kunos G. Cinar R, et al. Among authors: coffey nj. JCI Insight. 2017 Apr 20;2(8):e92281. doi: 10.1172/jci.insight.92281. eCollection 2017 Apr 20. JCI Insight. 2017. PMID: 28422760 Free PMC article.

4

Synthesis of S-2-((S)-3-(4-chlorophenyl)-N'-((4-chlorophenyl)sulfonyl)-4-phenyl-4,5-dihydro-1H-pyrazole-1-carboximidamido)-3-(methyl-d₃ )butanamide-d₅ , octadeuterated JD5037.

Iyer MR, Cinar R, Coffey NJ, Chorvat RJ, Kunos G. Iyer MR, et al. Among authors: coffey nj. J Labelled Comp Radiopharm. 2017 Aug;60(10):460-465. doi: 10.1002/jlcr.3521. Epub 2017 Aug 2. J Labelled Comp Radiopharm. 2017. PMID: 28545167 Free PMC article.

5

Cannabinoid-1 receptor deletion in podocytes mitigates both glomerular and tubular dysfunction in a mouse model of diabetic nephropathy.

Jourdan T, Park JK, Varga ZV, Pálóczi J, Coffey NJ, Rosenberg AZ, Godlewski G, Cinar R, Mackie K, Pacher P, Kunos G. Jourdan T, et al. Among authors: coffey nj. Diabetes Obes Metab. 2018 Mar;20(3):698-708. doi: 10.1111/dom.13150. Epub 2017 Dec 3. Diabetes Obes Metab. 2018. PMID: 29106063

6

Decreasing CB₁ receptor signaling in Kupffer cells improves insulin sensitivity in obese mice.

Jourdan T, Nicoloro SM, Zhou Z, Shen Y, Liu J, Coffey NJ, Cinar R, Godlewski G, Gao B, Aouadi M, Czech MP, Kunos G. Jourdan T, et al. Among authors: coffey nj. Mol Metab. 2017 Nov;6(11):1517-1528. doi: 10.1016/j.molmet.2017.08.011. Epub 2017 Sep 1. Mol Metab. 2017. PMID: 29107297 Free PMC article.

7

Crystal Structure of the Human Cannabinoid Receptor CB2.

Li X, Hua T, Vemuri K, Ho JH, Wu Y, Wu L, Popov P, Benchama O, Zvonok N, Locke K, Qu L, Han GW, Iyer MR, Cinar R, Coffey NJ, Wang J, Wu M, Katritch V, Zhao S, Kunos G, Bohn LM, Makriyannis A, Stevens RC, Liu ZJ. Li X, et al. Among authors: coffey nj. Cell. 2019 Jan 24;176(3):459-467.e13. doi: 10.1016/j.cell.2018.12.011. Epub 2019 Jan 10. Cell. 2019. PMID: 30639103 Free PMC article.

8

Targeting Peripheral CB₁ Receptors Reduces Ethanol Intake via a Gut-Brain Axis.

Godlewski G, Cinar R, Coffey NJ, Liu J, Jourdan T, Mukhopadhyay B, Chedester L, Liu Z, Osei-Hyiaman D, Iyer MR, Park JK, Smith RG, Iwakura H, Kunos G. Godlewski G, et al. Among authors: coffey nj. Cell Metab. 2019 Jun 4;29(6):1320-1333.e8. doi: 10.1016/j.cmet.2019.04.012. Epub 2019 May 16. Cell Metab. 2019. PMID: 31105045 Free PMC article.

9

Cholesterol as a modulator of cannabinoid receptor CB₂ signaling.

Yeliseev A, Iyer MR, Joseph TT, Coffey NJ, Cinar R, Zoubak L, Kunos G, Gawrisch K. Yeliseev A, et al. Among authors: coffey nj. Sci Rep. 2021 Feb 12;11(1):3706. doi: 10.1038/s41598-021-83245-6. Sci Rep. 2021. PMID: 33580091 Free PMC article.

10

Functional Selectivity of a Biased Cannabinoid-1 Receptor (CB₁R) Antagonist.

Liu Z, Iyer MR, Godlewski G, Jourdan T, Liu J, Coffey NJ, Zawatsky CN, Puhl HL, Wess J, Meister J, Liow JS, Innis RB, Hassan SA, Lee YS, Kunos G, Cinar R. Liu Z, et al. Among authors: coffey nj. ACS Pharmacol Transl Sci. 2021 Apr 8;4(3):1175-1187. doi: 10.1021/acsptsci.1c00048. eCollection 2021 Jun 11. ACS Pharmacol Transl Sci. 2021. PMID: 34151207 Free PMC article.

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