Cohen F - Search Results

1

Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models.

Patel S, Cohen F, Dean BJ, De La Torre K, Deshmukh G, Estrada AA, Ghosh AS, Gibbons P, Gustafson A, Huestis MP, Le Pichon CE, Lin H, Liu W, Liu X, Liu Y, Ly CQ, Lyssikatos JP, Ma C, Scearce-Levie K, Shin YG, Solanoy H, Stark KL, Wang J, Wang B, Zhao X, Lewcock JW, Siu M. Patel S, et al. Among authors: cohen f. J Med Chem. 2015 Jan 8;58(1):401-18. doi: 10.1021/jm5013984. Epub 2014 Oct 23. J Med Chem. 2015. PMID: 25341110

2

In vitro antimalarial activity of chalcones and their derivatives.

Li R, Kenyon GL, Cohen FE, Chen X, Gong B, Dominguez JN, Davidson E, Kurzban G, Miller RE, Nuzum EO, et al. Li R, et al. Among authors: cohen fe. J Med Chem. 1995 Dec 22;38(26):5031-7. doi: 10.1021/jm00026a010. J Med Chem. 1995. PMID: 8544179

3

Aryl ureas represent a new class of anti-trypanosomal agents.

Du X, Hansell E, Engel JC, Caffrey CR, Cohen FE, McKerrow JH. Du X, et al. Among authors: cohen fe. Chem Biol. 2000 Sep;7(9):733-42. doi: 10.1016/s1074-5521(00)00018-1. Chem Biol. 2000. PMID: 10980453

4

Synthesis and structure-activity relationship study of potent trypanocidal thio semicarbazone inhibitors of the trypanosomal cysteine protease cruzain.

Du X, Guo C, Hansell E, Doyle PS, Caffrey CR, Holler TP, McKerrow JH, Cohen FE. Du X, et al. J Med Chem. 2002 Jun 20;45(13):2695-707. doi: 10.1021/jm010459j. J Med Chem. 2002. PMID: 12061873

5

Structure-activity relationship study of prion inhibition by 2-aminopyridine-3,5-dicarbonitrile-based compounds: parallel synthesis, bioactivity, and in vitro pharmacokinetics.

May BC, Zorn JA, Witkop J, Sherrill J, Wallace AC, Legname G, Prusiner SB, Cohen FE. May BC, et al. J Med Chem. 2007 Jan 11;50(1):65-73. doi: 10.1021/jm061045z. J Med Chem. 2007. PMID: 17201410

6

Orally bioavailable antagonists of inhibitor of apoptosis proteins based on an azabicyclooctane scaffold.

Cohen F, Alicke B, Elliott LO, Flygare JA, Goncharov T, Keteltas SF, Franklin MC, Frankovitz S, Stephan JP, Tsui V, Vucic D, Wong H, Fairbrother WJ. Cohen F, et al. J Med Chem. 2009 Mar 26;52(6):1723-30. doi: 10.1021/jm801450c. J Med Chem. 2009. PMID: 19228017

7

Antagonists of inhibitor of apoptosis proteins based on thiazole amide isosteres.

Cohen F, Koehler MF, Bergeron P, Elliott LO, Flygare JA, Franklin MC, Gazzard L, Keteltas SF, Lau K, Ly CQ, Tsui V, Fairbrother WJ. Cohen F, et al. Bioorg Med Chem Lett. 2010 Apr 1;20(7):2229-33. doi: 10.1016/j.bmcl.2010.02.021. Epub 2010 Feb 8. Bioorg Med Chem Lett. 2010. PMID: 20189383

8

Targeting inhibitor of apoptosis proteins for therapeutic intervention.

Ndubaku C, Cohen F, Varfolomeev E, Vucic D. Ndubaku C, et al. Among authors: cohen f. Future Med Chem. 2009 Nov;1(8):1509-25. doi: 10.4155/fmc.09.116. Future Med Chem. 2009. PMID: 21426063 Review.

9

Potent, selective, and orally bioavailable inhibitors of mammalian target of rapamycin (mTOR) kinase based on a quaternary substituted dihydrofuropyrimidine.

Cohen F, Bergeron P, Blackwood E, Bowman KK, Chen H, Dipasquale AG, Epler JA, Koehler MF, Lau K, Lewis C, Liu L, Ly CQ, Malek S, Nonomiya J, Ortwine DF, Pei Z, Robarge KD, Sideris S, Trinh L, Truong T, Wu J, Zhao X, Lyssikatos JP. Cohen F, et al. J Med Chem. 2011 May 12;54(9):3426-35. doi: 10.1021/jm200215y. Epub 2011 Apr 15. J Med Chem. 2011. PMID: 21495671

10

A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C.

Mintzer R, Ramaswamy S, Shah K, Hannoush RN, Pozniak CD, Cohen F, Zhao X, Plise E, Lewcock JW, Heise CE. Mintzer R, et al. Among authors: cohen f. PLoS One. 2012;7(1):e30376. doi: 10.1371/journal.pone.0030376. Epub 2012 Jan 12. PLoS One. 2012. PMID: 22253931 Free PMC article.

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