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Mitochondrial pyruvate carrier regulates autophagy, inflammation, and neurodegeneration in experimental models of Parkinson's disease.
Ghosh A, Tyson T, George S, Hildebrandt EN, Steiner JA, Madaj Z, Schulz E, Machiela E, McDonald WG, Escobar Galvis ML, Kordower JH, Van Raamsdonk JM, Colca JR, Brundin P. Ghosh A, et al. Among authors: colca jr. Sci Transl Med. 2016 Dec 7;8(368):368ra174. doi: 10.1126/scitranslmed.aag2210. Sci Transl Med. 2016. PMID: 27928028
Mitochondrial target of thiazolidinediones.
Colca JR, McDonald WG, Kletzien RF. Colca JR, et al. Diabetes Obes Metab. 2014 Nov;16(11):1048-54. doi: 10.1111/dom.12308. Epub 2014 May 22. Diabetes Obes Metab. 2014. PMID: 24774061 Review.
Inhibiting the mitochondrial pyruvate carrier does not ameliorate synucleinopathy in the absence of inflammation or metabolic deficits.
Peelaerts W, Bergkvist L, George S, Johnson M, Meyerdirk L, Schulz E, Steiner JA, Madaj Z, Ma J, Becker K, Nilsson KPR, Colca JR, Brundin P. Peelaerts W, et al. Among authors: colca jr. Free Neuropathol. 2020;1:1-33. doi: 10.17879/freeneuropathology-2020-3049. Epub 2020 Nov 25. Free Neuropathol. 2020. PMID: 35224554 Free PMC article.
110 results