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Inhibition of mitochondrial pyruvate transport by zaprinast causes massive accumulation of aspartate at the expense of glutamate in the retina.
Du J, Cleghorn WM, Contreras L, Lindsay K, Rountree AM, Chertov AO, Turner SJ, Sahaboglu A, Linton J, Sadilek M, Satrústegui J, Sweet IR, Paquet-Durand F, Hurley JB. Du J, et al. Among authors: contreras l. J Biol Chem. 2013 Dec 13;288(50):36129-40. doi: 10.1074/jbc.M113.507285. Epub 2013 Nov 1. J Biol Chem. 2013. PMID: 24187136 Free PMC article.
Reduced N-acetylaspartate levels in mice lacking aralar, a brain- and muscle-type mitochondrial aspartate-glutamate carrier.
Jalil MA, Begum L, Contreras L, Pardo B, Iijima M, Li MX, Ramos M, Marmol P, Horiuchi M, Shimotsu K, Nakagawa S, Okubo A, Sameshima M, Isashiki Y, Del Arco A, Kobayashi K, Satrústegui J, Saheki T. Jalil MA, et al. Among authors: contreras l. J Biol Chem. 2005 Sep 2;280(35):31333-9. doi: 10.1074/jbc.M505286200. Epub 2005 Jun 29. J Biol Chem. 2005. PMID: 15987682 Free article.
Cytosolic reducing power preserves glutamate in retina.
Du J, Cleghorn W, Contreras L, Linton JD, Chan GC, Chertov AO, Saheki T, Govindaraju V, Sadilek M, Satrústegui J, Hurley JB. Du J, et al. Among authors: contreras l. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18501-6. doi: 10.1073/pnas.1311193110. Epub 2013 Oct 14. Proc Natl Acad Sci U S A. 2013. PMID: 24127593 Free PMC article.
387 results