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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1792 1
1802 1
1827 1
1837 1
1842 2
1843 1
1844 2
1845 2
1847 2
1848 1
1852 1
1853 1
1854 2
1855 1
1856 1
1858 1
1861 1
1870 4
1876 1
1879 1
1880 1
1881 2
1883 4
1884 1
1885 3
1886 2
1887 2
1888 2
1889 4
1891 5
1892 7
1893 1
1894 1
1896 1
1897 1
1902 1
1903 1
1904 1
1905 12
1907 3
1908 2
1909 1
1911 1
1913 1
1914 5
1915 2
1917 1
1919 1
1920 2
1921 2
1922 3
1924 3
1925 8
1926 7
1927 6
1928 1
1929 4
1930 8
1931 16
1932 6
1933 6
1934 8
1935 5
1936 4
1937 6
1938 4
1939 6
1940 4
1941 8
1942 4
1943 4
1944 2
1945 26
1946 64
1947 63
1948 83
1949 56
1950 100
1951 109
1952 100
1953 124
1954 106
1955 132
1956 117
1957 151
1958 130
1959 107
1960 123
1961 173
1962 191
1963 305
1964 426
1965 392
1966 427
1967 549
1968 681
1969 734
1970 725
1971 742
1972 818
1973 866
1974 929
1975 938
1976 951
1977 893
1978 938
1979 1039
1980 1053
1981 1072
1982 975
1983 1114
1984 1088
1985 1167
1986 1208
1987 1217
1988 1232
1989 1359
1990 1356
1991 1384
1992 1412
1993 1412
1994 1454
1995 1629
1996 1676
1997 1605
1998 1752
1999 1847
2000 2176
2001 2548
2002 2613
2003 2868
2004 3259
2005 3654
2006 3991
2007 4363
2008 4686
2009 4673
2010 4996
2011 5629
2012 5773
2013 6083
2014 6432
2015 6761
2016 6605
2017 6632
2018 7181
2019 7925
2020 8389
2021 8742
2022 9163
2023 9310
2024 3661

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164,194 results

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Page 1
Copper: effects of deficiency and overload.
Scheiber I, Dringen R, Mercer JF. Scheiber I, et al. Met Ions Life Sci. 2013;13:359-87. doi: 10.1007/978-94-007-7500-8_11. Met Ions Life Sci. 2013. PMID: 24470097 Free article. Review.
However, since an excess of copper can also harm cells due to its potential to catalyze the generation of toxic reactive oxygen species, transport of copper and the cellular copper content are tightly regulated. ...In addition, we will give an overview on dis …
However, since an excess of copper can also harm cells due to its potential to catalyze the generation of toxic reactive oxygen speci …
Copper-induced cell death.
Kahlson MA, Dixon SJ. Kahlson MA, et al. Science. 2022 Mar 18;375(6586):1231-1232. doi: 10.1126/science.abo3959. Epub 2022 Mar 17. Science. 2022. PMID: 35298241
Excess copper causes mitochondrial protein aggregation and triggers a distinct form of cell death....
Excess copper causes mitochondrial protein aggregation and triggers a distinct form of cell death....
Copper-induced tumor cell death mechanisms and antitumor theragnostic applications of copper complexes.
Jiang Y, Huo Z, Qi X, Zuo T, Wu Z. Jiang Y, et al. Nanomedicine (Lond). 2022 Feb;17(5):303-324. doi: 10.2217/nnm-2021-0374. Epub 2022 Jan 21. Nanomedicine (Lond). 2022. PMID: 35060391 Review.
This review first highlights three typical forms of copper's antitumor mechanisms. Then, the development of diverse biomaterials and nanotechnology allowing copper to be fabricated into diverse structures to realize its theragnostic action is discussed. Novel …
This review first highlights three typical forms of copper's antitumor mechanisms. Then, the development of diverse biomateria …
Cope with copper: From copper linked mechanisms to copper-based clinical cancer therapies.
Wang X, Zhou M, Liu Y, Si Z. Wang X, et al. Cancer Lett. 2023 May 1;561:216157. doi: 10.1016/j.canlet.2023.216157. Epub 2023 Apr 1. Cancer Lett. 2023. PMID: 37011869 Review.
Recent studies have established a strong link between copper and cancer biology, as copper is necessary for cancer growth and metastasis. ...In this review, we summarized the current understanding of copper's biological role and related molecular mecha …
Recent studies have established a strong link between copper and cancer biology, as copper is necessary for cancer growth and …
Copper.
Barceloux DG. Barceloux DG. J Toxicol Clin Toxicol. 1999;37(2):217-30. doi: 10.1081/clt-100102421. J Toxicol Clin Toxicol. 1999. PMID: 10382557 Review.
Following zinc and iron, copper is the third most abundant trace element in the body. Copper is a noble metal, like silver and gold. Useful industrial properties include high thermal and electrical conductivity, low corrosion, alloying ability, and malleability. Mos …
Following zinc and iron, copper is the third most abundant trace element in the body. Copper is a noble metal, like silver and …
Copper and immunity.
Percival SS. Percival SS. Am J Clin Nutr. 1998 May;67(5 Suppl):1064S-1068S. doi: 10.1093/ajcn/67.5.1064S. Am J Clin Nutr. 1998. PMID: 9587153 Review.
Animal models and cells in culture have been used to assess copper's role in the immune response. Some of the recent research showed that interleukin 2 is reduced in copper deficiency and is likely the mechanism by which T cell proliferation is reduced. ...Th …
Animal models and cells in culture have been used to assess copper's role in the immune response. Some of the recent research …
Copper in medicine.
Brewer GJ. Brewer GJ. Curr Opin Chem Biol. 2003 Apr;7(2):207-12. doi: 10.1016/s1367-5931(03)00018-8. Curr Opin Chem Biol. 2003. PMID: 12714053 Review.
The indication of the role of copper in formation of amyloid plaques in Alzheimer's disease, and successful treatment of an Alzheimer's rodent model by copper chelation are also potentially important. There have also been recent developments in the genetic and non-g …
The indication of the role of copper in formation of amyloid plaques in Alzheimer's disease, and successful treatment of an Alzheimer …
The promise of copper ionophores as antimicrobials.
O'Brien H, Davoodian T, Johnson MDL. O'Brien H, et al. Curr Opin Microbiol. 2023 Oct;75:102355. doi: 10.1016/j.mib.2023.102355. Epub 2023 Jul 3. Curr Opin Microbiol. 2023. PMID: 37406562 Free article. Review.
Unfortunately, due to microbial adaptation to develop resistance, some antibiotics are nullified early in their usage, and worse, resistance is detected before they can even be prescribed. Copper's toxicity since antiquity against microbes at the host-pathogen inter …
Unfortunately, due to microbial adaptation to develop resistance, some antibiotics are nullified early in their usage, and worse, resistance …
Elesclomol, a copper-transporting therapeutic agent targeting mitochondria: from discovery to its novel applications.
Tarin M, Babaie M, Eshghi H, Matin MM, Saljooghi AS. Tarin M, et al. J Transl Med. 2023 Oct 20;21(1):745. doi: 10.1186/s12967-023-04533-5. J Transl Med. 2023. PMID: 37864163 Free PMC article. Review.
Copper (Cu) is an essential element that is involved in a variety of biochemical processes. ...The production of reactive oxygen species (ROS), oxidative stress, and cuproptosis are among the proposed mechanisms of copper toxicity at high concentrations. Elesclomol …
Copper (Cu) is an essential element that is involved in a variety of biochemical processes. ...The production of reactive oxygen spec …
164,194 results
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