Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
Rosado-Ramos R, Poças GM, Marques D, Foito A, M Sevillano D, Lopes-da-Silva M, Gonçalves LG, Menezes R, Ottens M, Stewart D, Ibáñez de Opakua A, Zweckstetter M, Seabra MC, Mendes CS, Outeiro TF, Domingos PM, Santos CN.
Rosado-Ramos R, et al.
Nat Commun. 2023 Apr 6;14(1):1918. doi: 10.1038/s41467-023-37561-2.
Nat Commun. 2023.
PMID: 37024503
Free PMC article.
We have previously shown that a (poly)phenol-enriched fraction (PEF) of Corema album L. leaf extract modulates central events in PD pathogenesis, namely alpha-synuclein (alphaSyn) toxicity, aggregation and clearance. ...
We have previously shown that a (poly)phenol-enriched fraction (PEF) of Corema album L. leaf extract modulates central events in PD p …