Cosconati S - Search Results

1

Limongelli V, De Tito S, Cerofolini L, Fragai M, Pagano B, Trotta R, Cosconati S, Marinelli L, Novellino E, Bertini I, Randazzo A, Luchinat C, Parrinello M. Limongelli V, et al. Among authors: cosconati s. Angew Chem Int Ed Engl. 2013 Feb 18;52(8):2269-73. doi: 10.1002/anie.201206522. Epub 2013 Jan 17. Angew Chem Int Ed Engl. 2013. PMID: 23335456 No abstract available.

2

Tandem application of virtual screening and NMR experiments in the discovery of brand new DNA quadruplex groove binders.

Cosconati S, Marinelli L, Trotta R, Virno A, Mayol L, Novellino E, Olson AJ, Randazzo A. Cosconati S, et al. J Am Chem Soc. 2009 Nov 18;131(45):16336-7. doi: 10.1021/ja9063662. J Am Chem Soc. 2009. PMID: 19856964

3

Structural and conformational requisites in DNA quadruplex groove binding: another piece to the puzzle.

Cosconati S, Marinelli L, Trotta R, Virno A, De Tito S, Romagnoli R, Pagano B, Limongelli V, Giancola C, Baraldi PG, Mayol L, Novellino E, Randazzo A. Cosconati S, et al. J Am Chem Soc. 2010 May 12;132(18):6425-33. doi: 10.1021/ja1003872. J Am Chem Soc. 2010. PMID: 20394365

4

A more detailed picture of the interactions between virtual screening-derived hits and the DNA G-quadruplex: NMR, molecular modelling and ITC studies.

Trotta R, De Tito S, Lauri I, La Pietra V, Marinelli L, Cosconati S, Martino L, Conte MR, Mayol L, Novellino E, Randazzo A. Trotta R, et al. Among authors: cosconati s. Biochimie. 2011 Aug;93(8):1280-7. doi: 10.1016/j.biochi.2011.05.021. Epub 2011 May 30. Biochimie. 2011. PMID: 21658428

5

State-of-the-art methodologies for the discovery and characterization of DNA G-quadruplex binders.

Pagano B, Cosconati S, Gabelica V, Petraccone L, De Tito S, Marinelli L, La Pietra V, di Leva FS, Lauri I, Trotta R, Novellino E, Giancola C, Randazzo A. Pagano B, et al. Among authors: cosconati s. Curr Pharm Des. 2012;18(14):1880-99. doi: 10.2174/138161212799958332. Curr Pharm Des. 2012. PMID: 22376104 Free article. Review.

6

Shooting for selective druglike G-quadruplex binders: evidence for telomeric DNA damage and tumor cell death.

Cosconati S, Rizzo A, Trotta R, Pagano B, Iachettini S, De Tito S, Lauri I, Fotticchia I, Giustiniano M, Marinelli L, Giancola C, Novellino E, Biroccio A, Randazzo A. Cosconati S, et al. J Med Chem. 2012 Nov 26;55(22):9785-92. doi: 10.1021/jm301019w. Epub 2012 Oct 18. J Med Chem. 2012. PMID: 23057850

7

Discovery of the first dual G-triplex/G-quadruplex stabilizing compound: a new opportunity in the targeting of G-rich DNA structures?

Amato J, Pagano A, Cosconati S, Amendola G, Fotticchia I, Iaccarino N, Marinello J, De Magis A, Capranico G, Novellino E, Pagano B, Randazzo A. Amato J, et al. Among authors: cosconati s. Biochim Biophys Acta Gen Subj. 2017 May;1861(5 Pt B):1271-1280. doi: 10.1016/j.bbagen.2016.11.008. Epub 2016 Nov 9. Biochim Biophys Acta Gen Subj. 2017. PMID: 27836755

8

Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity.

Giustiniano M, Daniele S, Pelliccia S, La Pietra V, Pietrobono D, Brancaccio D, Cosconati S, Messere A, Giuntini S, Cerofolini L, Fragai M, Luchinat C, Taliani S, La Regina G, Da Settimo F, Silvestri R, Martini C, Novellino E, Marinelli L. Giustiniano M, et al. Among authors: cosconati s. J Med Chem. 2017 Oct 12;60(19):8115-8130. doi: 10.1021/acs.jmedchem.7b00912. Epub 2017 Sep 30. J Med Chem. 2017. PMID: 28921985

9

Characterizing the 1,4-dihydropyridines binding interactions in the L-type Ca2+ channel: model construction and docking calculations.

Cosconati S, Marinelli L, Lavecchia A, Novellino E. Cosconati S, et al. J Med Chem. 2007 Apr 5;50(7):1504-13. doi: 10.1021/jm061245a. Epub 2007 Mar 3. J Med Chem. 2007. PMID: 17335186

10

Ensemble-docking approach on BACE-1: pharmacophore perception and guidelines for drug design.

Limongelli V, Marinelli L, Cosconati S, Braun HA, Schmidt B, Novellino E. Limongelli V, et al. Among authors: cosconati s. ChemMedChem. 2007 May;2(5):667-78. doi: 10.1002/cmdc.200600314. ChemMedChem. 2007. PMID: 17407105

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