Cowan-Jacob SW - Search Results

1

Microseed matrix screening for optimization in protein crystallization: what have we learned?

D'Arcy A, Bergfors T, Cowan-Jacob SW, Marsh M. D'Arcy A, et al. Acta Crystallogr F Struct Biol Commun. 2014 Sep;70(Pt 9):1117-26. doi: 10.1107/S2053230X14015507. Epub 2014 Aug 29. Acta Crystallogr F Struct Biol Commun. 2014. PMID: 25195878 Free PMC article.

2

Structural biology contributions to the discovery of drugs to treat chronic myelogenous leukaemia.

Cowan-Jacob SW, Fendrich G, Floersheimer A, Furet P, Liebetanz J, Rummel G, Rheinberger P, Centeleghe M, Fabbro D, Manley PW. Cowan-Jacob SW, et al. Acta Crystallogr D Biol Crystallogr. 2007 Jan;63(Pt 1):80-93. doi: 10.1107/S0907444906047287. Epub 2006 Dec 13. Acta Crystallogr D Biol Crystallogr. 2007. PMID: 17164530 Free PMC article.

3

Structure of rabbit-muscle glyceraldehyde-3-phosphate dehydrogenase.

Cowan-Jacob SW, Kaufmann M, Anselmo AN, Stark W, Grütter MG. Cowan-Jacob SW, et al. Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2218-27. doi: 10.1107/s0907444903020493. Epub 2003 Nov 27. Acta Crystallogr D Biol Crystallogr. 2003. PMID: 14646080

4

Inhibitors of the Abl kinase directed at either the ATP- or myristate-binding site.

Fabbro D, Manley PW, Jahnke W, Liebetanz J, Szyttenholm A, Fendrich G, Strauss A, Zhang J, Gray NS, Adrian F, Warmuth M, Pelle X, Grotzfeld R, Berst F, Marzinzik A, Cowan-Jacob SW, Furet P, Mestan J. Fabbro D, et al. Biochim Biophys Acta. 2010 Mar;1804(3):454-62. doi: 10.1016/j.bbapap.2009.12.009. Biochim Biophys Acta. 2010. PMID: 20152788

5

Identification of a 5-[3-phenyl-(2-cyclic-ether)-methylether]-4-aminopyrrolo[2,3-d]pyrimidine series of IGF-1R inhibitors.

Stauffer F, Cowan-Jacob SW, Scheufler C, Furet P. Stauffer F, et al. Among authors: cowan jacob sw. Bioorg Med Chem Lett. 2016 Apr 15;26(8):2065-7. doi: 10.1016/j.bmcl.2016.02.074. Epub 2016 Feb 26. Bioorg Med Chem Lett. 2016. PMID: 26951750

6

Structural biology of protein tyrosine kinases.

Cowan-Jacob SW. Cowan-Jacob SW. Cell Mol Life Sci. 2006 Nov;63(22):2608-25. doi: 10.1007/s00018-006-6202-8. Cell Mol Life Sci. 2006. PMID: 17041812 Review.

7

2,6-Naphthyridines as potent and selective inhibitors of the novel protein kinase C isozymes.

van Eis MJ, Evenou JP, Floersheim P, Gaul C, Cowan-Jacob SW, Monovich L, Rummel G, Schuler W, Stark W, Strauss A, von Matt A, Vangrevelinghe E, Wagner J, Soldermann N. van Eis MJ, et al. Bioorg Med Chem Lett. 2011 Dec 15;21(24):7367-72. doi: 10.1016/j.bmcl.2011.10.025. Epub 2011 Oct 21. Bioorg Med Chem Lett. 2011. PMID: 22078216

8

Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K.

Altmann E, Cowan-Jacob SW, Missbach M. Altmann E, et al. J Med Chem. 2004 Nov 18;47(24):5833-6. doi: 10.1021/jm0493111. J Med Chem. 2004. PMID: 15537340

9

The crystal structure of a c-Src complex in an active conformation suggests possible steps in c-Src activation.

Cowan-Jacob SW, Fendrich G, Manley PW, Jahnke W, Fabbro D, Liebetanz J, Meyer T. Cowan-Jacob SW, et al. Structure. 2005 Jun;13(6):861-71. doi: 10.1016/j.str.2005.03.012. Structure. 2005. PMID: 15939018 Free article.

10

Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.

Schoepfer J, Jahnke W, Berellini G, Buonamici S, Cotesta S, Cowan-Jacob SW, Dodd S, Drueckes P, Fabbro D, Gabriel T, Groell JM, Grotzfeld RM, Hassan AQ, Henry C, Iyer V, Jones D, Lombardo F, Loo A, Manley PW, Pellé X, Rummel G, Salem B, Warmuth M, Wylie AA, Zoller T, Marzinzik AL, Furet P. Schoepfer J, et al. Among authors: cowan jacob sw. J Med Chem. 2018 Sep 27;61(18):8120-8135. doi: 10.1021/acs.jmedchem.8b01040. Epub 2018 Sep 7. J Med Chem. 2018. PMID: 30137981

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