Mitochondrial dysfunction abrogates dietary lipid processing in enterocytes.
Moschandrea C, Kondylis V, Evangelakos I, Herholz M, Schneider F, Schmidt C, Yang M, Ehret S, Heine M, Jaeckstein MY, Szczepanowska K, Schwarzer R, Baumann L, Bock T, Nikitopoulou E, Brodesser S, Krüger M, Frezza C, Heeren J, Trifunovic A, Pasparakis M.
Moschandrea C, et al.
Nature. 2024 Jan;625(7994):385-392. doi: 10.1038/s41586-023-06857-0. Epub 2023 Dec 20.
Nature. 2024.
PMID: 38123683
Free PMC article.
Mice with specific ablation of the mitochondrial aspartyl-tRNA synthetase DARS2 (ref. (2)), the respiratory chain subunit SDHA(3) or the assembly factor COX10 (ref. (4)) in intestinal epithelial cells showed accumulation of large lipid droplets (LDs) in enterocytes of the …
Mice with specific ablation of the mitochondrial aspartyl-tRNA synthetase DARS2 (ref. (2)), the respiratory chain subunit SDHA(3) or the ass …