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Cox15 is a novel oncogene that required for lung cancer cell proliferation.
Zhang C, Li N, Liu YY, Yuan T, Yang S, Wang XP. Zhang C, et al. Biochem Biophys Res Commun. 2021 Nov 12;578:70-76. doi: 10.1016/j.bbrc.2021.09.010. Epub 2021 Sep 14. Biochem Biophys Res Commun. 2021. PMID: 34547626
Here, we reveal that both transcription and protein expression levels of Cox15 were increased in lung cancer. Nrf2 specifically binds to the Cox15 promoter and triggers Cox15 expression at the transcriptional level. Cox15 functions as a novel oncogene …
Here, we reveal that both transcription and protein expression levels of Cox15 were increased in lung cancer. Nrf2 specifically binds …
Cox15 interacts with the cytochrome bc(1) dimer within respiratory supercomplexes as well as in the absence of cytochrome c oxidase.
Herwaldt EJ, Rivett ED, White AJ, Hegg EL. Herwaldt EJ, et al. J Biol Chem. 2018 Oct 19;293(42):16426-16439. doi: 10.1074/jbc.RA118.002496. Epub 2018 Sep 4. J Biol Chem. 2018. PMID: 30181213 Free PMC article.
To improve our understanding of heme a insertion into cytochrome c oxidase, here we investigated the protein-protein interactions that involve Cox15 in S. cerevisiae In addition to observing Cox15 in homooligomeric complexes, we found that a portion of Cox15 …
To improve our understanding of heme a insertion into cytochrome c oxidase, here we investigated the protein-protein interactions that invol …
Phenotypic variability and mutation hotspot in COX15-related Leigh syndrome.
Halperin D, Drabkin M, Wormser O, Yogev Y, Dolgin V, Shorer Z, Gradstein L, Shelef I, Flusser H, Birk OS. Halperin D, et al. Am J Med Genet A. 2020 Jun;182(6):1506-1512. doi: 10.1002/ajmg.a.61577. Epub 2020 Mar 31. Am J Med Genet A. 2020. PMID: 32232962
COX15 mutations were shown to underlie Leigh syndrome (LS), a progressive subacute necrotizing encephalopathy caused by defects in the mitochondrial respiratory chain. ...Interestingly, of the previously reported five cases of COX15-mutated patients, all of differen …
COX15 mutations were shown to underlie Leigh syndrome (LS), a progressive subacute necrotizing encephalopathy caused by defects in th …
A novel variant in the COX15 gene causing a fatal infantile cardioencephalomyopathy: A case report with clinical and molecular review.
Galvão de Oliveira M, Tengan C, Micheletti C, Ramos de Macedo P, Soares Pinho Cernach MC, Cavole TR, de França Basto M, Filho JS, Virmond LA, Milanezi F, Nakano V, Falconi A, Perrone E. Galvão de Oliveira M, et al. Eur J Med Genet. 2021 May;64(5):104195. doi: 10.1016/j.ejmg.2021.104195. Epub 2021 Mar 18. Eur J Med Genet. 2021. PMID: 33746038 Review.
Therefore, high energy demand organs and tissues are affected in patients with mutations in the COX15 gene, with variable phenotypic expressiveness. We describe the case of a male newborn with hypertrophic cardiomyopathy and serum and cerebrospinal fluid hyperlacticaemia, …
Therefore, high energy demand organs and tissues are affected in patients with mutations in the COX15 gene, with variable phenotypic …
Infantile cardioencephalopathy due to a COX15 gene defect: report and review.
Alfadhel M, Lillquist YP, Waters PJ, Sinclair G, Struys E, McFadden D, Hendson G, Hyams L, Shoffner J, Vallance HD. Alfadhel M, et al. Am J Med Genet A. 2011 Apr;155A(4):840-4. doi: 10.1002/ajmg.a.33881. Epub 2011 Mar 15. Am J Med Genet A. 2011. PMID: 21412973 Review.
Subsequent molecular investigations showed compound heterozygosity for two known pathogenic mutations in the COX15 gene. We compare the findings in our patient to those of the three previously reported cases....
Subsequent molecular investigations showed compound heterozygosity for two known pathogenic mutations in the COX15 gene. We compare t …
Multiple Origins of Eukaryotic cox15 Suggest Horizontal Gene Transfer from Bacteria to Jakobid Mitochondrial DNA.
He D, Fu CJ, Baldauf SL. He D, et al. Mol Biol Evol. 2016 Jan;33(1):122-33. doi: 10.1093/molbev/msv201. Epub 2015 Sep 27. Mol Biol Evol. 2016. PMID: 26412445
However, our analyses reveal two highly distinct HAS types (encoded by cox15-1 and cox15-2 genes) and identify A. godoyi mitochondrial cox15-encoded HAS as type-1 and all other eukaryotic cox15-encoded HAS as type-2. ...This suggests that not only is …
However, our analyses reveal two highly distinct HAS types (encoded by cox15-1 and cox15-2 genes) and identify A. godoyi mitoc …
The heme a synthase Cox15 associates with cytochrome c oxidase assembly intermediates during Cox1 maturation.
Bareth B, Dennerlein S, Mick DU, Nikolov M, Urlaub H, Rehling P. Bareth B, et al. Mol Cell Biol. 2013 Oct;33(20):4128-37. doi: 10.1128/MCB.00747-13. Epub 2013 Aug 26. Mol Cell Biol. 2013. PMID: 23979592 Free PMC article.
Our analyses suggest that Cox15 displays a role in cytochrome c oxidase assembly, which is independent of its functions as the heme a synthase. Cox15 forms protein complexes with Shy1 and also associates with Cox1-containing complexes independently of Shy1 function. …
Our analyses suggest that Cox15 displays a role in cytochrome c oxidase assembly, which is independent of its functions as the heme a …
COX15 codes for a mitochondrial protein essential for the assembly of yeast cytochrome oxidase.
Glerum DM, Muroff I, Jin C, Tzagoloff A. Glerum DM, et al. J Biol Chem. 1997 Jul 25;272(30):19088-94. doi: 10.1074/jbc.272.30.19088. J Biol Chem. 1997. PMID: 9228094 Free article.
These data suggest that the mutants are likely to be impaired in assembly of the enzyme. A gene designated COX15 has been cloned by transformation of mutants from complementation group G4. ...To facilitate further studies, Cox15p has been expressed as a biotinylated protei …
These data suggest that the mutants are likely to be impaired in assembly of the enzyme. A gene designated COX15 has been cloned by t …
Mutations in COX15 produce a defect in the mitochondrial heme biosynthetic pathway, causing early-onset fatal hypertrophic cardiomyopathy.
Antonicka H, Mattman A, Carlson CG, Glerum DM, Hoffbuhr KC, Leary SC, Kennaway NG, Shoubridge EA. Antonicka H, et al. Am J Hum Genet. 2003 Jan;72(1):101-14. doi: 10.1086/345489. Epub 2002 Dec 9. Am J Hum Genet. 2003. PMID: 12474143 Free PMC article.
Mutation analysis of COX15 in the patient identified a missense mutation (C700T) on one allele, changing a conserved arginine to tryptophan (R217W), and a splice-site mutation in intron 3 on the other allele (C447-3G), resulting in a deletion of exon 4. ...This study estab …
Mutation analysis of COX15 in the patient identified a missense mutation (C700T) on one allele, changing a conserved arginine to tryp …
Novel mutations in COX15 in a long surviving Leigh syndrome patient with cytochrome c oxidase deficiency.
Bugiani M, Tiranti V, Farina L, Uziel G, Zeviani M. Bugiani M, et al. J Med Genet. 2005 May;42(5):e28. doi: 10.1136/jmg.2004.029926. J Med Genet. 2005. PMID: 15863660 Free PMC article.
METHODS: We describe a patient with atypical, long surviving Leigh syndrome carrying two novel mutations in the COX15 gene, which encodes an enzyme involved in the biosynthesis of heme A. RESULTS: Only two COX15 mutated patients, one with severe neonatal cardiomyopa …
METHODS: We describe a patient with atypical, long surviving Leigh syndrome carrying two novel mutations in the COX15 gene, which enc …
82 results