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New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis.
Bold G, Altmann KH, Frei J, Lang M, Manley PW, Traxler P, Wietfeld B, Brüggen J, Buchdunger E, Cozens R, Ferrari S, Furet P, Hofmann F, Martiny-Baron G, Mestan J, Rösel J, Sills M, Stover D, Acemoglu F, Boss E, Emmenegger R, Lässer L, Masso E, Roth R, Schlachter C, Vetterli W. Bold G, et al. Among authors: cozens r. J Med Chem. 2000 Jun 15;43(12):2310-23. doi: 10.1021/jm9909443. J Med Chem. 2000. PMID: 10882357
New aza-dipeptide analogues as potent and orally absorbed HIV-1 protease inhibitors: candidates for clinical development.
Bold G, Fässler A, Capraro HG, Cozens R, Klimkait T, Lazdins J, Mestan J, Poncioni B, Rösel J, Stover D, Tintelnot-Blomley M, Acemoglu F, Beck W, Boss E, Eschbach M, Hürlimann T, Masso E, Roussel S, Ucci-Stoll K, Wyss D, Lang M. Bold G, et al. Among authors: cozens r. J Med Chem. 1998 Aug 27;41(18):3387-401. doi: 10.1021/jm970873c. J Med Chem. 1998. PMID: 9719591
PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.
Wood JM, Bold G, Buchdunger E, Cozens R, Ferrari S, Frei J, Hofmann F, Mestan J, Mett H, O'Reilly T, Persohn E, Rösel J, Schnell C, Stover D, Theuer A, Towbin H, Wenger F, Woods-Cook K, Menrad A, Siemeister G, Schirner M, Thierauch KH, Schneider MR, Drevs J, Martiny-Baron G, Totzke F. Wood JM, et al. Among authors: cozens r. Cancer Res. 2000 Apr 15;60(8):2178-89. Cancer Res. 2000. PMID: 10786682
New anilinophthalazines as potent and orally well absorbed inhibitors of the VEGF receptor tyrosine kinases useful as antagonists of tumor-driven angiogenesis.
Bold G, Altmann KH, Frei J, Lang M, Manley PW, Traxler P, Wietfeld B, Bruggen J, Buchdunger E, Cozens R, Ferrari S, Furet P, Hofmann F, Martiny-Baron G, Mestan J, Rosel J, Sills M, Stover D, Acemoglu F, Boss E, Emmenegger R, Lasser L, Masso E, Roth R, Schlachter C, Vetterli W. Bold G, et al. Among authors: cozens r. J Med Chem. 2000 Aug 10;43(16):3200. doi: 10.1021/jm001010d. J Med Chem. 2000. PMID: 10956229 No abstract available.
A potent protein-tyrosine kinase inhibitor which selectively blocks proliferation of epidermal growth factor receptor-expressing tumor cells in vitro and in vivo.
Lydon NB, Mett H, Mueller M, Becker M, Cozens RM, Stover D, Daniels D, Traxler P, Buchdunger E. Lydon NB, et al. Among authors: cozens rm. Int J Cancer. 1998 Mar 30;76(1):154-63. doi: 10.1002/(sici)1097-0215(19980330)76:1<154::aid-ijc24>3.0.co;2-b. Int J Cancer. 1998. PMID: 9533776 Free article. Retracted.
Synthesis of potent and orally active HIV-protease inhibitors.
Capraro HG, Bold G, Fässler A, Cozens R, Klimkait T, Lazdins J, Mestan J, Poncioni B, Rösel JL, Stover D, Lang M. Capraro HG, et al. Among authors: cozens r. Arch Pharm (Weinheim). 1996 Jun;329(6):273-8. doi: 10.1002/ardp.19963290602. Arch Pharm (Weinheim). 1996. PMID: 8767110
AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activity.
Traxler P, Allegrini PR, Brandt R, Brueggen J, Cozens R, Fabbro D, Grosios K, Lane HA, McSheehy P, Mestan J, Meyer T, Tang C, Wartmann M, Wood J, Caravatti G. Traxler P, et al. Among authors: cozens r. Cancer Res. 2004 Jul 15;64(14):4931-41. doi: 10.1158/0008-5472.CAN-03-3681. Cancer Res. 2004. PMID: 15256466
Profile of CGP 61755: a novel and potent HIV-1 protease inhibitor that shows enhanced anti-HIV activity when combined with other antiretroviral agents in vitro.
Lazdins JK, Bold G, Capraro HG, Cozens R, Fässler A, Flesch G, Klimkait T, Lang M, Mestan J, Poncioni B, Rösel J, Stover D, Tintelnot-Blomley M, Walker MR, Woods-Cook K. Lazdins JK, et al. Among authors: cozens r. Schweiz Med Wochenschr. 1996 Oct 26;126(43):1849-51. Schweiz Med Wochenschr. 1996. PMID: 8916294
In vivo antitumor activity of NVP-AEW541-A novel, potent, and selective inhibitor of the IGF-IR kinase.
García-Echeverría C, Pearson MA, Marti A, Meyer T, Mestan J, Zimmermann J, Gao J, Brueggen J, Capraro HG, Cozens R, Evans DB, Fabbro D, Furet P, Porta DG, Liebetanz J, Martiny-Baron G, Ruetz S, Hofmann F. García-Echeverría C, et al. Among authors: cozens r. Cancer Cell. 2004 Mar;5(3):231-9. doi: 10.1016/s1535-6108(04)00051-0. Cancer Cell. 2004. PMID: 15050915 Free article.
37 results