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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1989 1
1990 2
1991 1
1993 3
1994 2
1995 6
1997 2
1998 3
1999 6
2000 1
2001 5
2002 4
2003 3
2004 5
2005 6
2006 8
2007 4
2008 7
2009 6
2010 9
2011 12
2012 10
2013 9
2014 8
2015 9
2016 13
2017 14
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2020 11
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2022 12
2023 17
2024 9

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214 results

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Page 1
CRHBP is degraded via autophagy and exerts anti-hepatocellular carcinoma effects by reducing cyclin B2 expression and dissociating cyclin B2-CDK1 complex.
Wang Z, Li M, Liu Y, Qiao Z, Yang L, Liu B, Bai T. Wang Z, et al. Cancer Gene Ther. 2022 Aug;29(8-9):1217-1227. doi: 10.1038/s41417-021-00423-4. Epub 2022 Jan 27. Cancer Gene Ther. 2022. PMID: 35082401
This study aimed to explore (1) the role of CRHBP in HCC development, and (2) whether p62-mediated autophagy was responsible for low CRHBP expression within HCC tissue. ...CRHBP downregulation in HCC may attribute to p62-mediated autophagy....
This study aimed to explore (1) the role of CRHBP in HCC development, and (2) whether p62-mediated autophagy was responsible for low …
Decreased CRHBP expression is predictive of poor prognosis in patients with hepatocellular carcinoma.
Xia HB, Wang HJ, Fu LQ, Wang SB, Li L, Ru GQ, He XL, Tong XM, Mou XZ, Huang DS. Xia HB, et al. Oncol Lett. 2018 Sep;16(3):3681-3689. doi: 10.3892/ol.2018.9073. Epub 2018 Jul 4. Oncol Lett. 2018. PMID: 30127978 Free PMC article.
Patients exhibiting low CRHBP expression were associated with shorter survival time compared with those exhibiting high CRHBP expression (P=0.012). The results of western blotting analysis suggest that reduced CRHBP expression is frequently observable in pati …
Patients exhibiting low CRHBP expression were associated with shorter survival time compared with those exhibiting high CRHBP …
Integrative analysis reveals CRHBP inhibits renal cell carcinoma progression by regulating inflammation and apoptosis.
Yang K, Xiao Y, Xu T, Yu W, Ruan Y, Luo P, Cheng F. Yang K, et al. Cancer Gene Ther. 2020 Aug;27(7-8):607-618. doi: 10.1038/s41417-019-0138-2. Epub 2019 Oct 1. Cancer Gene Ther. 2020. PMID: 31570754 Free PMC article.
Overexpression of CRHBP suppressed cell proliferation, migration, invasion as well as apoptosis in vitro and in vivo. ...Our results suggested that CRHBP may be an effective target to treat ccRCC patients....
Overexpression of CRHBP suppressed cell proliferation, migration, invasion as well as apoptosis in vitro and in vivo. ...Our results …
Characterization of CRH-Binding Protein (CRHBP) in Chickens: Molecular Cloning, Tissue Distribution and Investigation of Its Role as a Negative Feedback Regulator within the Hypothalamus-Pituitary-Adrenal Axis.
Wan Y, Zhang Z, Lin D, Wang X, Huang T, Su J, Zhang J, Li J, Wang Y. Wan Y, et al. Genes (Basel). 2022 Sep 20;13(10):1680. doi: 10.3390/genes13101680. Genes (Basel). 2022. PMID: 36292565 Free PMC article.
In contrast to the extensive investigation of CRHBP in mammals and other lower vertebrates, the gene structure, tissue expression and physiological functions of CRHBP in birds remain largely unknown. ...The characterization of the chicken CRHBP gene helps to …
In contrast to the extensive investigation of CRHBP in mammals and other lower vertebrates, the gene structure, tissue expression and …
CRHBP polymorphisms predict chronic pain development following motor vehicle collision.
Linnstaedt SD, Bortsov AV, Soward AC, Swor R, Peak DA, Jones J, Rathlev N, Lee DC, Domeier R, Hendry PL, McLean SA. Linnstaedt SD, et al. Pain. 2016 Jan;157(1):273-279. doi: 10.1097/j.pain.0000000000000374. Pain. 2016. PMID: 26447706 Free PMC article.
Two additional CRHBP alleles in high linkage disequilibrium with rs7718461 also showed trend-level significance. ...A significant CRHBP FKBP5 interaction was also observed, with substantially increased MSP after MVC in those with a risk allele in both genes compared …
Two additional CRHBP alleles in high linkage disequilibrium with rs7718461 also showed trend-level significance. ...A significant …
The Effect of CRHBP rs10062367 Polymorphism and Parenting Styles on Internalizing Problems in Preschoolers: The Moderating Effect of Sensory Processing Sensitivity.
Zeng S, Liu C, Wang Z. Zeng S, et al. Child Psychiatry Hum Dev. 2022 Sep 17. doi: 10.1007/s10578-022-01418-4. Online ahead of print. Child Psychiatry Hum Dev. 2022. PMID: 36114994
The present study aimed to examine how CRHBP rs10062367 polymorphism interacted with parenting styles and sensory processing sensitivity (SPS) to impact on preschoolers' internalizing problems. A total of 446 preschoolers (M(age) = 4.55, SD = 1.07) participated in the stud …
The present study aimed to examine how CRHBP rs10062367 polymorphism interacted with parenting styles and sensory processing sensitiv …
Downregulation of CRHBP is associated with trophoblast invasion inhibition in recurrent pregnancy loss.
Sun F, Cui L, Qian J, Du M, Wang S. Sun F, et al. Reproduction. 2023 Dec 14;167(1):e230326. doi: 10.1530/REP-23-0326. Print 2024 Jan 1. Reproduction. 2023. PMID: 37947291
This study shows that abnormal CRHBP expression could be an early warning sign of recurrent pregnancy loss and that CRHBP knockdown could suppress HTR8/SVneo cell invasion by the PKC signaling pathway via interacting with CRH receptor 2. ...To further characterize i …
This study shows that abnormal CRHBP expression could be an early warning sign of recurrent pregnancy loss and that CRHBP knoc …
The GCAG Haplotype of the CRHBP Gene May Decrease the Risk for Robbery Behavior Among the Han Chinese.
Tang L, Chen Y, Xiang Q, Xiang J, Tang Y, Li J. Tang L, et al. Genet Test Mol Biomarkers. 2020 Jul;24(7):436-442. doi: 10.1089/gtmb.2020.0011. Epub 2020 Jun 16. Genet Test Mol Biomarkers. 2020. PMID: 32551975
However, no study has been conducted on the relationship between CRHBP polymorphisms and aggressive behavior risk in the Han Chinese population. Methods: A case-control study that comprised 194 male criminals and 303 healthy controls was carried out to investigate the gene …
However, no study has been conducted on the relationship between CRHBP polymorphisms and aggressive behavior risk in the Han Chinese …
Two HPA axis genes, CRHBP and FKBP5, interact with childhood trauma to increase the risk for suicidal behavior.
Roy A, Hodgkinson CA, Deluca V, Goldman D, Enoch MA. Roy A, et al. J Psychiatr Res. 2012 Jan;46(1):72-9. doi: 10.1016/j.jpsychires.2011.09.009. Epub 2011 Oct 5. J Psychiatr Res. 2012. PMID: 21978546 Free PMC article.
Corticotropin releasing hormone (CRH) regulates the HPA axis and its actions are moderated by a high-affinity binding protein (CRHBP). We hypothesized that CRHBP variation and interaction with childhood trauma might influence suicidal behavior. ...CRHBP varia …
Corticotropin releasing hormone (CRH) regulates the HPA axis and its actions are moderated by a high-affinity binding protein (CRHBP) …
otpb functions in a Lef1-dependent transcriptional network required for expression of the stress response inhibitor crhbp in the zebrafish hypothalamus.
Figueroa P, Cheng J, Wang G, Kartchner C, Brito de Andrade D, Watters H, Crispell E, Dorsky RI. Figueroa P, et al. bioRxiv [Preprint]. 2023 Jun 9:2023.06.07.544119. doi: 10.1101/2023.06.07.544119. bioRxiv. 2023. PMID: 37333084 Free PMC article. Preprint.
Here we show that otpb expression in the posterior hypothalamus is Lef1-dependent, and that like lef1 , its function is required for the generation of crhbp + neurons in this region. Transgenic reporter analysis of a crhbp conserved noncoding element suggests that o …
Here we show that otpb expression in the posterior hypothalamus is Lef1-dependent, and that like lef1 , its function is required for the gen …
214 results