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Year Number of Results
1996 5
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1998 7
1999 6
2000 13
2001 21
2002 18
2003 27
2004 31
2005 28
2006 34
2007 35
2008 44
2009 47
2010 39
2011 48
2012 70
2013 65
2014 64
2015 47
2016 59
2017 66
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975 results

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Page 1
CRHR1 endocytosis: Spatiotemporal regulation of receptor signaling.
Dos Santos Claro PA, Silbermins M, Inda C, Silberstein S. Dos Santos Claro PA, et al. Prog Mol Biol Transl Sci. 2023;196:229-260. doi: 10.1016/bs.pmbts.2022.07.015. Epub 2022 Aug 30. Prog Mol Biol Transl Sci. 2023. PMID: 36813360 Review.
We review and describe cellular components and molecular mechanisms involved in CRH system signaling through G protein-coupled receptors (GPCRs) CRHR1 and CRHR2, under the current view of GPCR signaling from the plasma membrane but also from intracellular compartments, whi …
We review and describe cellular components and molecular mechanisms involved in CRH system signaling through G protein-coupled receptors (GP …
CRHR1 antagonist alleviates LPS-induced depression-like behaviour in mice.
Sun J, Qiu L, Zhang H, Zhou Z, Ju L, Yang J. Sun J, et al. BMC Psychiatry. 2023 Jan 9;23(1):17. doi: 10.1186/s12888-023-04519-z. BMC Psychiatry. 2023. PMID: 36624454 Free PMC article.
The hippocampal protein levels of CRHR1, nectin3, and calbindin were measured by western blotting. ...CONCLUSION: CRHR1antagonist showed antidepressant effects in LPS-induced depressive mice, and CRHR1/nectin3 signalling may play a crucial role in this process....
The hippocampal protein levels of CRHR1, nectin3, and calbindin were measured by western blotting. ...CONCLUSION: CRHR1antagonist sho …
Association between FKBP5 and CRHR1 genes with suicidal behavior: A systematic review.
De la Cruz-Cano E. De la Cruz-Cano E. Behav Brain Res. 2017 Jan 15;317:46-61. doi: 10.1016/j.bbr.2016.09.032. Epub 2016 Sep 13. Behav Brain Res. 2017. PMID: 27638035 Review.
This review showed a significant genetic association in most studies in FKBP5 and CRHR1 genes with a high rate of attempted suicide, pointing out that the expression of these genes and its polymorphisms could be a key predictor of suicide risk. In conclusion, this systemat …
This review showed a significant genetic association in most studies in FKBP5 and CRHR1 genes with a high rate of attempted suicide, …
The CRHR1/CREB/REST signaling cascade regulates mammalian embryonic neural stem cell properties.
Kwon M, Lee JH, Yoon Y, Pleasure SJ, Yoon K. Kwon M, et al. EMBO Rep. 2023 Feb 6;24(2):e55313. doi: 10.15252/embr.202255313. Epub 2022 Nov 22. EMBO Rep. 2023. PMID: 36413000 Free PMC article.
Identifying the underlying molecular mechanisms of CRHR1 action, we find that CRHR1 functions are accomplished through the increasing expression of the master transcription factor REST. Furthermore, luciferase reporter and chromatin immunoprecipitation assays reveal …
Identifying the underlying molecular mechanisms of CRHR1 action, we find that CRHR1 functions are accomplished through the inc …
CRHR1 promoter hypomethylation: An epigenetic readout of panic disorder?
Schartner C, Ziegler C, Schiele MA, Kollert L, Weber H, Zwanzger P, Arolt V, Pauli P, Deckert J, Reif A, Domschke K. Schartner C, et al. Eur Neuropsychopharmacol. 2017 Apr;27(4):360-371. doi: 10.1016/j.euroneuro.2017.01.005. Epub 2017 Feb 21. Eur Neuropsychopharmacol. 2017. PMID: 28233670
CRHR1 gene variation is associated with several mental disorders including anxiety disorders. ...In panic disorder patients, a significantly decreased CRHR1 methylation was discerned (p<0.001). Accordingly, healthy controls with high BAI scores showed significant …
CRHR1 gene variation is associated with several mental disorders including anxiety disorders. ...In panic disorder patients, a signif …
CRH/CRHR1 modulates cerebrovascular endothelial cell permeability in association with S1PR2 and S1PR3 under oxidative stress.
Mu J, Que Y, Li X, Zhou F, Jin L, Li S, Zhu C. Mu J, et al. Vascul Pharmacol. 2022 Feb;142:106941. doi: 10.1016/j.vph.2021.106941. Epub 2021 Nov 13. Vascul Pharmacol. 2022. PMID: 34781017
However, little is known about the linkage between S1PRs and CRHR1 in oxidative stress-induced cerebrovascular endothelial hyperpermeability. Here we observed the opposite effects of S1PR2 to those of S1PR3 on the monolayer permeability of bEnd3 cells in response to H(2)O( …
However, little is known about the linkage between S1PRs and CRHR1 in oxidative stress-induced cerebrovascular endothelial hyperperme …
CRHR1 mediates the transcriptional expression of pituitary hormones and their receptors under hypoxia.
Wang TY, Xia FY, Gong JW, Xu XK, Lv MC, Chatoo M, Shamsi BH, Zhang MC, Liu QR, Liu TX, Zhang DD, Lu XJ, Zhao Y, Du JZ, Chen XQ. Wang TY, et al. Front Endocrinol (Lausanne). 2022 Sep 2;13:893238. doi: 10.3389/fendo.2022.893238. eCollection 2022. Front Endocrinol (Lausanne). 2022. PMID: 36147561 Free PMC article.
The receptors were also implicated in the regulation of functions of target cells in the pituitary network under hypoxic stress. CRHR1 played an integrative role in the hypothalamus-pituitary-target axes. This study provides new evidence for CRHR1 involved changes o …
The receptors were also implicated in the regulation of functions of target cells in the pituitary network under hypoxic stress. CRHR1 …
Genetics of generalized anxiety disorder and related traits.
Gottschalk MG, Domschke K. Gottschalk MG, et al. Dialogues Clin Neurosci. 2017 Jun;19(2):159-168. doi: 10.31887/DCNS.2017.19.2/kdomschke. Dialogues Clin Neurosci. 2017. PMID: 28867940 Free PMC article. Review.
We explore etiologic factors in gene-environment interaction approaches investigating childhood trauma, environmental adversity, and stressful life events in relation to selected candidate genes (5-HTT, NPSR1, COMT, MAOA, CRHR1, RGS2), Additionally, the pharmacogenetics of …
We explore etiologic factors in gene-environment interaction approaches investigating childhood trauma, environmental adversity, and stressf …
CRHR1 polymorphism at rs242941, rs242940, and rs72834580: association of symptoms improvement with intranasal corticosteroids in allergic rhinitis Jordanian patients.
Zihlif M, Abusara OH, Al-Qerem W, Al-Ibadah M, Mahafza TM, Al-Akhras FM, Mahafza NT. Zihlif M, et al. Drug Metab Pers Ther. 2023 May 22;38(4):331-338. doi: 10.1515/dmpt-2023-0014. eCollection 2023 Dec 1. Drug Metab Pers Ther. 2023. PMID: 37216433
The responsiveness to corticosteroids is due to their binding to corticotropin-releasing hormone receptor-1 (CRHR1). Various studies have studied the responsiveness to corticosteroids treatment in patients with asthma and COPD in association with CRHR1 gene single n …
The responsiveness to corticosteroids is due to their binding to corticotropin-releasing hormone receptor-1 (CRHR1). Various studies …
CRHR1 links peripuberty stress with deficits in social and stress-coping behaviors.
Veenit V, Riccio O, Sandi C. Veenit V, et al. J Psychiatr Res. 2014 Jun;53:1-7. doi: 10.1016/j.jpsychires.2014.02.015. Epub 2014 Feb 28. J Psychiatr Res. 2014. PMID: 24630468 Free article.
Here, we investigated whether stress exposure during the peripubertal period - comprising juvenility and puberty - is effective in inducing long-lasting changes in the expression of CRHR1 and CRHR2 in the hippocampus and amygdala, and whether treating animals with a CRH …
Here, we investigated whether stress exposure during the peripubertal period - comprising juvenility and puberty - is effective in inducing …
975 results