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Page 1
CRISP2 Is a Regulator of Multiple Aspects of Sperm Function and Male Fertility.
Lim S, Kierzek M, O'Connor AE, Brenker C, Merriner DJ, Okuda H, Volpert M, Gaikwad A, Bianco D, Potter D, Prabhakar R, Strünker T, O'Bryan MK. Lim S, et al. Endocrinology. 2019 Apr 1;160(4):915-924. doi: 10.1210/en.2018-01076. Endocrinology. 2019. PMID: 30759213
In this study we tested the necessity for CRISP2 in male fertility using Crisp2 loss-of-function mouse models. ...Collectively, these data define CRISP2 as a determinant of male fertility and explain previous clinical associations between human CRISP2 …
In this study we tested the necessity for CRISP2 in male fertility using Crisp2 loss-of-function mouse models. ...Collectively …
The fate of porcine sperm CRISP2 from the perinuclear theca before and after in vitro fertilization.
Zhang M, Bromfield EG, Helms JB, Gadella BM. Zhang M, et al. Biol Reprod. 2022 Nov 14;107(5):1242-1253. doi: 10.1093/biolre/ioac169. Biol Reprod. 2022. PMID: 36054334 Free PMC article.
The fate of sperm head CRISP2 was further examined post-fertilization. In vitro matured porcine oocytes were co-incubated with boar sperm cells for 6-8 h and the zygotes were processed for CRISP2 immunofluorescent staining. ...Reduction of disulfide bridges within …
The fate of sperm head CRISP2 was further examined post-fertilization. In vitro matured porcine oocytes were co-incubated with boar s …
CRISP2, CATSPER1 and PATE1 Expression in Human Asthenozoospermic Semen.
Manfrevola F, Ferraro B, Sellitto C, Rocco D, Fasano S, Pierantoni R, Chianese R. Manfrevola F, et al. Cells. 2021 Jul 31;10(8):1956. doi: 10.3390/cells10081956. Cells. 2021. PMID: 34440724 Free PMC article.
Recently, we have identified differentially expressed circRNAs (DE-circRNAs) in normozoospermic and asthenozoospermic patients, associated with high-quality (A-spermatozoa) and low-quality (B-spermatozoa) sperm. Here, we carried out a differential analysis of CRISP2, CATSP …
Recently, we have identified differentially expressed circRNAs (DE-circRNAs) in normozoospermic and asthenozoospermic patients, associated w …
Human sperm CRISP2 is released from the acrosome during the acrosome reaction and re-associates at the equatorial segment.
Nimlamool W, Bean BS, Lowe-Krentz LJ. Nimlamool W, et al. Mol Reprod Dev. 2013 Jun;80(6):488-502. doi: 10.1002/mrd.22189. Epub 2013 May 30. Mol Reprod Dev. 2013. PMID: 23661501
Here, we provide evidence showing the re-association of sperm acrosomal CRISP2 at the EqS during the acrosome reaction. Results showed that F-actin is not involved in the relocalization of CRISP2. ...Interestingly, the restriction of CRISP2 at the EqS was dim …
Here, we provide evidence showing the re-association of sperm acrosomal CRISP2 at the EqS during the acrosome reaction. Results showe …
Evaluation of testicular sperm CRISP2 as a potential target for contraception.
Muñoz MW, Ernesto JI, Bluguermann C, Busso D, Battistone MA, Cohen DJ, Cuasnicú PS. Muñoz MW, et al. J Androl. 2012 Nov-Dec;33(6):1360-70. doi: 10.2164/jandrol.112.016725. Epub 2012 May 31. J Androl. 2012. PMID: 22653965
Western blot studies revealed that anti-CRISP2 sera were capable of recognizing CRISP2 in testicular, epididymal, and sperm extracts, whereas histological studies showed no evidence of autoimmune orchitis or epididymitis. ...Moreover, anti-CRISP2 sera signifi …
Western blot studies revealed that anti-CRISP2 sera were capable of recognizing CRISP2 in testicular, epididymal, and sperm ex …
Characterization of different oligomeric forms of CRISP2 in the perinuclear theca versus the fibrous tail structures of boar spermatozoa.
Zhang M, Bromfield EG, Veenendaal T, Klumperman J, Helms JB, Gadella BM. Zhang M, et al. Biol Reprod. 2021 Nov 15;105(5):1160-1170. doi: 10.1093/biolre/ioab145. Biol Reprod. 2021. PMID: 34309660
The tail oligomers were insensitive to reducing conditions but nearly complete dissociated into monomers under 8 M urea treatment, while the head 250 kDa CRISP2 positive oligomer completely dissociated into CRISP2 monomers under reducing conditions. The head specifi …
The tail oligomers were insensitive to reducing conditions but nearly complete dissociated into monomers under 8 M urea treatment, while the …
Evidence for the involvement of testicular protein CRISP2 in mouse sperm-egg fusion.
Busso D, Goldweic NM, Hayashi M, Kasahara M, Cuasnicú PS. Busso D, et al. Biol Reprod. 2007 Apr;76(4):701-8. doi: 10.1095/biolreprod.106.056770. Epub 2007 Jan 3. Biol Reprod. 2007. PMID: 17202389
CRISP2, originally known as Tpx-1, is a cysteine-rich secretory protein specifically expressed in male haploid germ cells. Although likely to be involved in gamete interaction, evidence for a functional role of CRISP2 in fertilization still remains poor. In the pres …
CRISP2, originally known as Tpx-1, is a cysteine-rich secretory protein specifically expressed in male haploid germ cells. Although l …
Expression Analysis of the CRISP2, CATSPER1, PATE1 and SEMG1 in the Sperm of Men with Idiopathic Asthenozoospermia.
Heidary Z, Zaki-Dizaji M, Saliminejad K, Khorramkhorshid HR. Heidary Z, et al. J Reprod Infertil. 2019 Apr-Jun;20(2):70-75. J Reprod Infertil. 2019. PMID: 31058050 Free PMC article.
BACKGROUND: The purpose of this study was to analyze the expression level of CRISP2, CATSPER1, PATE1 and SEMG1 genes in the sperm of men with asthenozoospermia (AZS). ...Mann-Whitney test was used to compare the expression levels between the case and control groups with si …
BACKGROUND: The purpose of this study was to analyze the expression level of CRISP2, CATSPER1, PATE1 and SEMG1 genes in the sperm of …
Association of CRISP2, CCT8, PEBP1 mRNA abundance in sperm and sire conception rate in Holstein bulls.
Arangasamy A, Kasimanickam VR, DeJarnette JM, Kasimanickam RK. Arangasamy A, et al. Theriogenology. 2011 Aug;76(3):570-7. doi: 10.1016/j.theriogenology.2011.03.009. Epub 2011 May 6. Theriogenology. 2011. PMID: 21529916
However, in the absence of CRISP2 mRNA abundance in the model, the SCR-score's predictability of PEBP1 was significant. ...In conclusion, Holstein bulls with greater CRISP2 and lower CCT8 mRNA expression in sperm had higher probabilities of siring calves....
However, in the absence of CRISP2 mRNA abundance in the model, the SCR-score's predictability of PEBP1 was significant. ...In conclus …
The expression of cysteine-rich secretory protein 2 (CRISP2) and its specific regulator miR-27b in the spermatozoa of patients with asthenozoospermia.
Zhou JH, Zhou QZ, Lyu XM, Zhu T, Chen ZJ, Chen MK, Xia H, Wang CY, Qi T, Li X, Liu CD. Zhou JH, et al. Biol Reprod. 2015 Jan;92(1):28. doi: 10.1095/biolreprod.114.124487. Epub 2014 Dec 10. Biol Reprod. 2015. PMID: 25505194
Herein, we carried out a study focusing on the CRISP2 reduction and its roles in asthenozoospermia. Initially, through analyzing CRISP2 expression and methylation on CRISP2 promoter activity in sperm, we observed a decreased expression of CRISP2 protei …
Herein, we carried out a study focusing on the CRISP2 reduction and its roles in asthenozoospermia. Initially, through analyzing C …
107 results