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Limited antigenic diversity of Plasmodium falciparum apical membrane antigen 1 supports the development of effective multi-allele vaccines.
Terheggen U, Drew DR, Hodder AN, Cross NJ, Mugyenyi CK, Barry AE, Anders RF, Dutta S, Osier FH, Elliott SR, Senn N, Stanisic DI, Marsh K, Siba PM, Mueller I, Richards JS, Beeson JG. Terheggen U, et al. Among authors: cross nj. BMC Med. 2014 Oct 16;12:183. doi: 10.1186/s12916-014-0183-5. BMC Med. 2014. PMID: 25319190 Free PMC article.
Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development.
Richards JS, Arumugam TU, Reiling L, Healer J, Hodder AN, Fowkes FJ, Cross N, Langer C, Takeo S, Uboldi AD, Thompson JK, Gilson PR, Coppel RL, Siba PM, King CL, Torii M, Chitnis CE, Narum DL, Mueller I, Crabb BS, Cowman AF, Tsuboi T, Beeson JG. Richards JS, et al. J Immunol. 2013 Jul 15;191(2):795-809. doi: 10.4049/jimmunol.1300778. Epub 2013 Jun 17. J Immunol. 2013. PMID: 23776179 Free PMC article.
A phase 1 trial of MSP2-C1, a blood-stage malaria vaccine containing 2 isoforms of MSP2 formulated with Montanide® ISA 720.
McCarthy JS, Marjason J, Elliott S, Fahey P, Bang G, Malkin E, Tierney E, Aked-Hurditch H, Adda C, Cross N, Richards JS, Fowkes FJ, Boyle MJ, Long C, Druilhe P, Beeson JG, Anders RF. McCarthy JS, et al. PLoS One. 2011;6(9):e24413. doi: 10.1371/journal.pone.0024413. Epub 2011 Sep 19. PLoS One. 2011. PMID: 21949716 Free PMC article. Clinical Trial.
Synergistic malaria vaccine combinations identified by systematic antigen screening.
Bustamante LY, Powell GT, Lin YC, Macklin MD, Cross N, Kemp A, Cawkill P, Sanderson T, Crosnier C, Muller-Sienerth N, Doumbo OK, Traore B, Crompton PD, Cicuta P, Tran TM, Wright GJ, Rayner JC. Bustamante LY, et al. Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12045-12050. doi: 10.1073/pnas.1702944114. Epub 2017 Oct 23. Proc Natl Acad Sci U S A. 2017. PMID: 29078270 Free PMC article.
A forward genetic screen reveals a primary role for Plasmodium falciparum Reticulocyte Binding Protein Homologue 2a and 2b in determining alternative erythrocyte invasion pathways.
Campino S, Marin-Menendez A, Kemp A, Cross N, Drought L, Otto TD, Benavente ED, Ravenhall M, Schwach F, Girling G, Manske M, Theron M, Gould K, Drury E, Clark TG, Kwiatkowski DP, Pance A, Rayner JC. Campino S, et al. PLoS Pathog. 2018 Nov 29;14(11):e1007436. doi: 10.1371/journal.ppat.1007436. eCollection 2018 Nov. PLoS Pathog. 2018. PMID: 30496294 Free PMC article.
21 results