Crossan GP - Search Results

1

Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.

Garaycoechea JI, Crossan GP, Langevin F, Mulderrig L, Louzada S, Yang F, Guilbaud G, Park N, Roerink S, Nik-Zainal S, Stratton MR, Patel KJ. Garaycoechea JI, et al. Among authors: crossan gp. Nature. 2018 Jan 11;553(7687):171-177. doi: 10.1038/nature25154. Epub 2018 Jan 3. Nature. 2018. PMID: 29323295 Free PMC article.

2

Disruption of mouse Slx4, a regulator of structure-specific nucleases, phenocopies Fanconi anemia.

Crossan GP, van der Weyden L, Rosado IV, Langevin F, Gaillard PHL, McIntyre RE; Sanger Mouse Genetics Project; Gallagher F, Kettunen MI, Lewis DY, Brindle K, Arends MJ, Adams DJ, Patel KJ. Crossan GP, et al. Nat Genet. 2011 Feb;43(2):147-52. doi: 10.1038/ng.752. Epub 2011 Jan 16. Nat Genet. 2011. PMID: 21240276 Free PMC article.

3

Fancd2 counteracts the toxic effects of naturally produced aldehydes in mice.

Langevin F, Crossan GP, Rosado IV, Arends MJ, Patel KJ. Langevin F, et al. Among authors: crossan gp. Nature. 2011 Jul 6;475(7354):53-8. doi: 10.1038/nature10192. Nature. 2011. PMID: 21734703

4

The Fanconi anaemia pathway orchestrates incisions at sites of crosslinked DNA.

Crossan GP, Patel KJ. Crossan GP, et al. J Pathol. 2012 Jan;226(2):326-37. doi: 10.1002/path.3002. Epub 2011 Oct 25. J Pathol. 2012. PMID: 21956823 Review.

5

Formaldehyde catabolism is essential in cells deficient for the Fanconi anemia DNA-repair pathway.

Rosado IV, Langevin F, Crossan GP, Takata M, Patel KJ. Rosado IV, et al. Among authors: crossan gp. Nat Struct Mol Biol. 2011 Nov 13;18(12):1432-4. doi: 10.1038/nsmb.2173. Nat Struct Mol Biol. 2011. PMID: 22081012

6

"Ring-fencing" BRCA1 tumor suppressor activity.

Patel KJ, Crossan GP, Hodskinson MR. Patel KJ, et al. Among authors: crossan gp. Cancer Cell. 2011 Dec 13;20(6):693-5. doi: 10.1016/j.ccr.2011.11.019. Cancer Cell. 2011. PMID: 22172717 Free article.

7

Genotoxic consequences of endogenous aldehydes on mouse haematopoietic stem cell function.

Garaycoechea JI, Crossan GP, Langevin F, Daly M, Arends MJ, Patel KJ. Garaycoechea JI, et al. Among authors: crossan gp. Nature. 2012 Sep 27;489(7417):571-5. doi: 10.1038/nature11368. Epub 2012 Aug 26. Nature. 2012. PMID: 22922648

8

[Aldehydes and Fanconi anaemia: the enemy within].

Langevin FP, Garaycoechea JI, Crossan GP, Patel KJ. Langevin FP, et al. Among authors: crossan gp. Med Sci (Paris). 2013 Apr;29(4):361-4. doi: 10.1051/medsci/2013294009. Epub 2013 Apr 26. Med Sci (Paris). 2013. PMID: 23621931 Free article. French. No abstract available.

9

Mouse SLX4 is a tumor suppressor that stimulates the activity of the nuclease XPF-ERCC1 in DNA crosslink repair.

Hodskinson MR, Silhan J, Crossan GP, Garaycoechea JI, Mukherjee S, Johnson CM, Schärer OD, Patel KJ. Hodskinson MR, et al. Among authors: crossan gp. Mol Cell. 2014 May 8;54(3):472-84. doi: 10.1016/j.molcel.2014.03.014. Epub 2014 Apr 10. Mol Cell. 2014. PMID: 24726326 Free PMC article.

10

Maternal aldehyde elimination during pregnancy preserves the fetal genome.

Oberbeck N, Langevin F, King G, de Wind N, Crossan GP, Patel KJ. Oberbeck N, et al. Among authors: crossan gp. Mol Cell. 2014 Sep 18;55(6):807-817. doi: 10.1016/j.molcel.2014.07.010. Epub 2014 Aug 21. Mol Cell. 2014. PMID: 25155611 Free PMC article.

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