Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 1
1993 1
1996 1
2003 1
2005 1
2006 1
2007 1
2011 1
2013 4
2014 1
2015 1
2018 1
2019 5
2020 6
2021 1
2022 3
2024 4

Text availability

Article attribute

Article type

Publication date

Search Results

32 results

Results by year

Filters applied: . Clear all
Page 1
Protein-crystal detection with a compact multimodal multiphoton microscope.
Cheng QD, Chung HY, Schubert R, Chia SH, Falke S, Mudogo CN, Kärtner FX, Chang G, Betzel C. Cheng QD, et al. Commun Biol. 2020 Oct 13;3(1):569. doi: 10.1038/s42003-020-01275-8. Commun Biol. 2020. PMID: 33051587 Free PMC article.
There is an increasing demand for rapid, effective methods to identify and detect protein micro- and nano-crystal suspensions for serial diffraction data collection at X-ray free-electron lasers or high-intensity micro-focus synchrotron radiation sources. Here, we demonstr …
There is an increasing demand for rapid, effective methods to identify and detect protein micro- and nano-crystal suspensions for ser …
Crystal structure of an extracellular superoxide dismutase from Onchocerca volvulus and implications for parasite-specific drug development.
Moustafa A, Perbandt M, Liebau E, Betzel C, Falke S. Moustafa A, et al. Acta Crystallogr F Struct Biol Commun. 2022 Jun 1;78(Pt 6):232-240. doi: 10.1107/S2053230X22005350. Epub 2022 May 27. Acta Crystallogr F Struct Biol Commun. 2022. PMID: 35647680 Free PMC article.
In the present study, an extracellular Cu/Zn-SOD from O. volvulus (OvEC-SOD) was cloned, purified and crystallized to obtain structural insight into an attractive drug target with the potential to combat onchocerciasis. ...
In the present study, an extracellular Cu/Zn-SOD from O. volvulus (OvEC-SOD) was cloned, purified and crystallized to obtain structur …
Protein phase separation and determinants of in cell crystallization.
Mudogo CN, Falke S, Brognaro H, Duszenko M, Betzel C. Mudogo CN, et al. Traffic. 2020 Feb;21(2):220-230. doi: 10.1111/tra.12711. Epub 2019 Nov 25. Traffic. 2020. PMID: 31664760 Free article. Review.
However, the occurrence of in cellulo crystals is also associated to diseases like cataract, hemoglobin C diseases, etc. Therefore, better knowledge about the involved molecular processes will support drug discovery investigations to cure diseases related to in cellulo …
However, the occurrence of in cellulo crystals is also associated to diseases like cataract, hemoglobin C diseases, etc. Therefore, b …
Crystal structure of a mirror-image L-RNA aptamer (Spiegelmer) in complex with the natural L-protein target CCL2.
Oberthür D, Achenbach J, Gabdulkhakov A, Buchner K, Maasch C, Falke S, Rehders D, Klussmann S, Betzel C. Oberthür D, et al. Nat Commun. 2015 Apr 22;6:6923. doi: 10.1038/ncomms7923. Nat Commun. 2015. PMID: 25901662 Free PMC article.
We report the crystal structure of a 40 mer mirror-image RNA oligonucleotide completely built from nucleotides of the non-natural L-chirality in complex with the pro-inflammatory chemokine L-CLL2 (monocyte chemoattractant protein-1), a natural protein composed of regular L …
We report the crystal structure of a 40 mer mirror-image RNA oligonucleotide completely built from nucleotides of the non-natural L-c …
[b]-Annulated Halogen-Substituted Indoles as Potential DYRK1A Inhibitors.
Lechner C, Flaßhoff M, Falke H, Preu L, Loaëc N, Meijer L, Knapp S, Chaikuad A, Kunick C. Lechner C, et al. Molecules. 2019 Nov 13;24(22):4090. doi: 10.3390/molecules24224090. Molecules. 2019. PMID: 31766108 Free PMC article.
In order to identify DYRK1A inhibitors with improved properties, a series of new chemicals based on [b]-annulated halogenated indoles were designed, synthesized, and evaluated for biological activity. Analysis of crystal structures revealed a typical type-I binding mode of …
In order to identify DYRK1A inhibitors with improved properties, a series of new chemicals based on [b]-annulated halogenated indoles were d …
Crystal Structure of Mistletoe Lectin I (ML-I) from Viscum album in Complex with 4-N-Furfurylcytosine at 2.85 A Resolution.
Ahmad MS, Rasheed S, Falke S, Khaliq B, Perbandt M, Choudhary MI, Markiewicz WT, Barciszewski J, Betzel C. Ahmad MS, et al. Med Chem. 2018;14(8):754-763. doi: 10.2174/1573406414666180524095946. Med Chem. 2018. PMID: 29792147
To understand the molecular basis for such medical applications, a few studies have already addressed the structural and functional analysis of ML-I in complex with ligands. In continuation of these efforts, we are reporting the crystal structure of ML from Viscum album in …
To understand the molecular basis for such medical applications, a few studies have already addressed the structural and functional analysis …
The C2 domain calcium-binding motif: structural and functional diversity.
Nalefski EA, Falke JJ. Nalefski EA, et al. Protein Sci. 1996 Dec;5(12):2375-90. doi: 10.1002/pro.5560051201. Protein Sci. 1996. PMID: 8976547 Free PMC article. Review.
This alignment predicts that C2 domains form two distinct topological folds, illustrated by the recent crystal structures of C2 domains from synaptotagmin 1 and phosphoinositide-specific phospholipase C-delta 1, respectively. ...
This alignment predicts that C2 domains form two distinct topological folds, illustrated by the recent crystal structures of C2 domai …
Crystal structures of native cytochrome c(6) from Thermosynechococcus elongatus in two different space groups and implications for its oligomerization.
Falke S, Feiler C, Chapman H, Sarrou I. Falke S, et al. Acta Crystallogr F Struct Biol Commun. 2020 Sep 1;76(Pt 9):444-452. doi: 10.1107/S2053230X20010249. Epub 2020 Aug 20. Acta Crystallogr F Struct Biol Commun. 2020. PMID: 32880593 Free PMC article.
Both crystal structures were solved; they contained three and six molecules per asymmetric unit and were refined to 1.7 and 2.25 A resolution, respectively. ...Furthermore, there is an indication of post-translational methylation in the crystal structure. Additional …
Both crystal structures were solved; they contained three and six molecules per asymmetric unit and were refined to 1.7 and 2.25 A re …
Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors.
Falke S, Lieske J, Herrmann A, Loboda J, Karničar K, Günther S, Reinke PYA, Ewert W, Usenik A, Lindič N, Sekirnik A, Dretnik K, Tsuge H, Turk V, Chapman HN, Hinrichs W, Ebert G, Turk D, Meents A. Falke S, et al. J Med Chem. 2024 May 9;67(9):7048-7067. doi: 10.1021/acs.jmedchem.3c02351. Epub 2024 Apr 17. J Med Chem. 2024. PMID: 38630165 Free PMC article.
We show a relevant off-target effect of CatL inhibition by the coronavirus main protease alpha-ketoamide inhibitor 13b. Crystal structures of CatL in complex with 14 compounds at resolutions better than 2 A present a solid basis for structure-guided understanding and optim …
We show a relevant off-target effect of CatL inhibition by the coronavirus main protease alpha-ketoamide inhibitor 13b. Crystal struc …
32 results