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Crystal structure of Streptococcus pneumoniae pneumolysin provides key insights into early steps of pore formation.
Lawrence SL, Feil SC, Morton CJ, Farrand AJ, Mulhern TD, Gorman MA, Wade KR, Tweten RK, Parker MW. Lawrence SL, et al. Sci Rep. 2015 Sep 25;5:14352. doi: 10.1038/srep14352. Sci Rep. 2015. PMID: 26403197 Free PMC article.
Here we present the structure of PLY determined by X-ray crystallography and, in solution, by small-angle X-ray scattering. The crystal structure reveals PLY assembles as a linear oligomer that provides key structural insights into the poorly understood early monomer-monom …
Here we present the structure of PLY determined by X-ray crystallography and, in solution, by small-angle X-ray scattering. The crystal
Mutational analysis of TraR. Correlating function with molecular structure of a quorum-sensing transcriptional activator.
Luo ZQ, Smyth AJ, Gao P, Qin Y, Farrand SK. Luo ZQ, et al. J Biol Chem. 2003 Apr 11;278(15):13173-82. doi: 10.1074/jbc.M210035200. Epub 2003 Feb 4. J Biol Chem. 2003. PMID: 12569101 Free article.
Additional residues located within the N-terminal half of TraR, including three located in alpha-helix 9, contribute to dimerization, but are not required for ligand binding. These results and the recently reported crystal structure of TraR are consistent with and compleme …
Additional residues located within the N-terminal half of TraR, including three located in alpha-helix 9, contribute to dimerization, but ar …
In situ evidence for an ancient aqueous environment at Meridiani Planum, Mars.
Squyres SW, Grotzinger JP, Arvidson RE, Bell JF 3rd, Calvin W, Christensen PR, Clark BC, Crisp JA, Farrand WH, Herkenhoff KE, Johnson JR, Klingelhöfer G, Knoll AH, McLennan SM, McSween HY Jr, Morris RV, Rice JW Jr, Rieder R, Soderblom LA. Squyres SW, et al. Science. 2004 Dec 3;306(5702):1709-14. doi: 10.1126/science.1104559. Science. 2004. PMID: 15576604
Cross-stratification observed in rock outcrops indicates eolian and aqueous transport. Diagenetic features include hematite-rich concretions and crystal-mold vugs. We interpret the rocks to be a mixture of chemical and siliciclastic sediments with a complex diagenetic hist …
Cross-stratification observed in rock outcrops indicates eolian and aqueous transport. Diagenetic features include hematite-rich concretions …
Structure of the lectin regulatory domain of the cholesterol-dependent cytolysin lectinolysin reveals the basis for its lewis antigen specificity.
Feil SC, Lawrence S, Mulhern TD, Holien JK, Hotze EM, Farrand S, Tweten RK, Parker MW. Feil SC, et al. Structure. 2012 Feb 8;20(2):248-58. doi: 10.1016/j.str.2011.11.017. Structure. 2012. PMID: 22325774 Free PMC article.
Streptococcus mitis lectinolysin (LLY) exhibits another layer of regulation with a lectin domain that enhances the pore-forming activity of the toxin. We have determined the crystal structures of the lectin domain by itself and in complex with various glycans that reveal t …
Streptococcus mitis lectinolysin (LLY) exhibits another layer of regulation with a lectin domain that enhances the pore-forming activity of …
Two years at Meridiani Planum: results from the Opportunity Rover.
Squyres SW, Knoll AH, Arvidson RE, Clark BC, Grotzinger JP, Jolliff BL, McLennan SM, Tosca N, Bell JF 3rd, Calvin WM, Farrand WH, Glotch TD, Golombek MP, Herkenhoff KE, Johnson JR, Klingelhöfer G, McSween HY, Yen AS. Squyres SW, et al. Science. 2006 Sep 8;313(5792):1403-7. doi: 10.1126/science.1130890. Science. 2006. PMID: 16959999
These include well-developed festoon (trough) cross-lamination formed in flowing liquid water, strata with smaller and more abundant hematite-rich concretions than those seen previously, possible relict "hopper crystals" that might reflect the formation of halite, thick we …
These include well-developed festoon (trough) cross-lamination formed in flowing liquid water, strata with smaller and more abundant hematit …