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Page 1
Drosophila as a Genetic Model for Hematopoiesis.
Banerjee U, Girard JR, Goins LM, Spratford CM. Banerjee U, et al. Genetics. 2019 Feb;211(2):367-417. doi: 10.1534/genetics.118.300223. Genetics. 2019. PMID: 30733377 Free PMC article. Review.
Paths and pathways that generate cell-type heterogeneity and developmental progression in hematopoiesis.
Girard JR, Goins LM, Vuu DM, Sharpley MS, Spratford CM, Mantri SR, Banerjee U. Girard JR, et al. Elife. 2021 Oct 29;10:e67516. doi: 10.7554/eLife.67516. Elife. 2021. PMID: 34713801 Free PMC article.
We highlight metabolism as a driver of development, show that graded Pointed expression allows distinct roles in successive developmental steps, and that mature crystal cells specifically express an alternate isoform of Hypoxia-inducible factor (Hif/Sima). ...
We highlight metabolism as a driver of development, show that graded Pointed expression allows distinct roles in successive developmental st …
Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013.
O'Reilly M, Federoff HJ, Fong Y, Kohn DB, Patterson AP, Ahmed N, Asokan A, Boye SE, Crystal RG, De Oliveira S, Gargiulo L, Harper SQ, Ikeda Y, Jambou R, Montgomery M, Prograis L, Rosenthal E, Sterman DH, Vandenberghe LH, Zoloth L, Abedi M, Adair J, Adusumilli PS, Goins WF, Gray J, Monahan P, Popplewell L, Sena-Esteves M, Tannous B, Weber T, Wierda W, Gopal-Srivastava R, McDonald CL, Rosenblum D, Corrigan-Curay J. O'Reilly M, et al. Hum Gene Ther. 2014 Jun;25(6):488-97. doi: 10.1089/hum.2014.045. Hum Gene Ther. 2014. PMID: 24773122 Free PMC article. Review.
Structural basis for lipid binding and mechanism of the Mycobacterium tuberculosis Rv3802 phospholipase.
Goins CM, Schreidah CM, Dajnowicz S, Ronning DR. Goins CM, et al. J Biol Chem. 2018 Jan 26;293(4):1363-1372. doi: 10.1074/jbc.RA117.000240. Epub 2017 Dec 15. J Biol Chem. 2018. PMID: 29247008 Free PMC article.
In this study, we present the first M. tuberculosis Rv3802 X-ray crystal structure, solved to 1.7 A resolution. On the basis of the binding of PEG molecules to Rv3802, we identified its lipid-binding site and the structural basis for phosphatidyl-based substrate binding an …
In this study, we present the first M. tuberculosis Rv3802 X-ray crystal structure, solved to 1.7 A resolution. On the basis of the b …
SARS-CoV-2 3CL-protease inhibitors derived from ML300: investigation of P1 and replacements of the 1,2,3-benzotriazole.
Hooper A, Macdonald JD, Reilly B, Maw J, Wirrick AP, Han SH, Lindsey AA, Rico EG, Romigh T, Goins CM, Wang NS, Stauffer S. Hooper A, et al. Res Sq [Preprint]. 2023 May 11:rs.3.rs-2880312. doi: 10.21203/rs.3.rs-2880312/v1. Res Sq. 2023. PMID: 37214977 Free PMC article. Preprint.
In addition, pyridyl and isoquinoline P1 groups were successful as P1 replacements leading to 3-methyl pyridyl 36 (IC(50) = 85 nM) and isoquinoline 27 (IC(50) = 26 nM). High resolution X-ray crystal structures of these inhibitors were utilized to confirm binding orientatio …
In addition, pyridyl and isoquinoline P1 groups were successful as P1 replacements leading to 3-methyl pyridyl 36 (IC(50) = 85 nM) and isoqu …
Mycolyltransferase from Mycobacterium tuberculosis in covalent complex with tetrahydrolipstatin provides insights into antigen 85 catalysis.
Goins CM, Dajnowicz S, Smith MD, Parks JM, Ronning DR. Goins CM, et al. J Biol Chem. 2018 Mar 9;293(10):3651-3662. doi: 10.1074/jbc.RA117.001681. Epub 2018 Jan 19. J Biol Chem. 2018. PMID: 29352107 Free PMC article.
To inform an updated model, we obtained an Ag85 acyl-enzyme intermediate structure that resembles the mycolated form. Here, we present a 1.45-A X-ray crystal structure of M. tuberculosis Ag85C covalently modified by tetrahydrolipstatin (THL), an esterase inhibitor that sup …
To inform an updated model, we obtained an Ag85 acyl-enzyme intermediate structure that resembles the mycolated form. Here, we present a 1.4 …
Characterization of Tetrahydrolipstatin and Stereoderivatives on the Inhibition of Essential Mycobacterium tuberculosis Lipid Esterases.
Goins CM, Sudasinghe TD, Liu X, Wang Y, O'Doherty GA, Ronning DR. Goins CM, et al. Biochemistry. 2018 Apr 24;57(16):2383-2393. doi: 10.1021/acs.biochem.8b00152. Epub 2018 Apr 10. Biochemistry. 2018. PMID: 29601187 Free PMC article.
The observed kinetic data for all three target enzymes are supported by recently published X-ray crystal structures of Ag85C, Rv3802, and Pks13-TE. Insights from this study provide a molecular basis for the kinetic modulation of three essential M. tuberculosis lipid estera …
The observed kinetic data for all three target enzymes are supported by recently published X-ray crystal structures of Ag85C, Rv3802, …
Development and growth of potato tubers in microgravity.
Cook ME, Croxdale JL, Tibbitts TW, Goins G, Brown CS, Wheeler RM. Cook ME, et al. Adv Space Res. 1998;21(8-9):1103-10. doi: 10.1016/s0273-1177(97)00197-x. Adv Space Res. 1998. PMID: 11541357
The range in starch grain size was similar in tubers from both environments, but the distribution of grains into size classes differed somewhat, with the space-grown tubers having more small grains than the ground control tubers. Proteinaceous crystals were found in tubers …
The range in starch grain size was similar in tubers from both environments, but the distribution of grains into size classes differed somew …
12 results