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The air-liquid interface and use of primary cell cultures are important to recapitulate the transcriptional profile of in vivo airway epithelia.
Pezzulo AA, Starner TD, Scheetz TE, Traver GL, Tilley AE, Harvey BG, Crystal RG, McCray PB Jr, Zabner J. Pezzulo AA, et al. Among authors: crystal rg. Am J Physiol Lung Cell Mol Physiol. 2011 Jan;300(1):L25-31. doi: 10.1152/ajplung.00256.2010. Epub 2010 Oct 22. Am J Physiol Lung Cell Mol Physiol. 2011. PMID: 20971803 Free PMC article.
Smoking is associated with shortened airway cilia.
Leopold PL, O'Mahony MJ, Lian XJ, Tilley AE, Harvey BG, Crystal RG. Leopold PL, et al. Among authors: crystal rg. PLoS One. 2009 Dec 16;4(12):e8157. doi: 10.1371/journal.pone.0008157. PLoS One. 2009. PMID: 20016779 Free PMC article.
Threshold of biologic responses of the small airway epithelium to low levels of tobacco smoke.
Strulovici-Barel Y, Omberg L, O'Mahony M, Gordon C, Hollmann C, Tilley AE, Salit J, Mezey J, Harvey BG, Crystal RG. Strulovici-Barel Y, et al. Among authors: crystal rg. Am J Respir Crit Care Med. 2010 Dec 15;182(12):1524-32. doi: 10.1164/rccm.201002-0294OC. Epub 2010 Aug 6. Am J Respir Crit Care Med. 2010. PMID: 20693378 Free PMC article.
Smoking accelerates aging of the small airway epithelium.
Walters MS, De BP, Salit J, Buro-Auriemma LJ, Wilson T, Rogalski AM, Lief L, Hackett NR, Staudt MR, Tilley AE, Harvey BG, Kaner RJ, Mezey JG, Ashbridge B, Moore MA, Crystal RG. Walters MS, et al. Among authors: crystal rg. Respir Res. 2014 Sep 24;15(1):94. doi: 10.1186/s12931-014-0094-1. Respir Res. 2014. PMID: 25248511 Free PMC article.
908 results