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2001 1
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217 results

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CSMD1 regulates brain complement activity and circuit development.
Baum ML, Wilton DK, Fox RG, Carey A, Hsu YH, Hu R, Jäntti HJ, Fahey JB, Muthukumar AK, Salla N, Crotty W, Scott-Hewitt N, Bien E, Sabatini DA, Lanser TB, Frouin A, Gergits F, Håvik B, Gialeli C, Nacu E, Lage K, Blom AM, Eggan K, McCarroll SA, Johnson MB, Stevens B. Baum ML, et al. Brain Behav Immun. 2024 Mar 27;119:317-332. doi: 10.1016/j.bbi.2024.03.041. Online ahead of print. Brain Behav Immun. 2024. PMID: 38552925 Free article.
We used biochemical, immunohistochemical, and proteomic techniques to examine the regional, cellular, and subcellular distribution as well as protein interactions of CSMD1 in the brain. To evaluate whether CSMD1 is involved in complement-mediated synapse elimination …
We used biochemical, immunohistochemical, and proteomic techniques to examine the regional, cellular, and subcellular distribution as well a …
The Diverse Role of CUB and Sushi Multiple Domains 1 (CSMD1) in Human Diseases.
Ermis Akyuz E, Bell SM. Ermis Akyuz E, et al. Genes (Basel). 2022 Dec 10;13(12):2332. doi: 10.3390/genes13122332. Genes (Basel). 2022. PMID: 36553598 Free PMC article. Review.
CUB and Sushi Multiple Domains 1 (CSMD1), a tumour suppressor gene, encodes a large membrane-bound protein including a single transmembrane domain. This transmembrane region has a potential tyrosine phosphorylation site, suggesting that CSMD1 is involved in controll …
CUB and Sushi Multiple Domains 1 (CSMD1), a tumour suppressor gene, encodes a large membrane-bound protein including a single transme …
CSMD1 suppresses cancer progression by inhibiting proliferation, epithelial-mesenchymal transition, chemotherapy-resistance and inducing immunosuppression in esophageal squamous cell carcinoma.
Wang X, Chen X, Liu Y, Huang S, Ding J, Wang B, Dong P, Sun Z, Chen L. Wang X, et al. Exp Cell Res. 2022 Aug 15;417(2):113220. doi: 10.1016/j.yexcr.2022.113220. Epub 2022 May 25. Exp Cell Res. 2022. PMID: 35623420
Reduced CSMD1 expression was correlated with a poor prognosis in ESCC patients. ...We further found that CSMD1-overexpression cells are more sensitive to chemotherapy. Moreover, we addressed the role of CSMD1 in the CD8(+) T cell immune response. ...
Reduced CSMD1 expression was correlated with a poor prognosis in ESCC patients. ...We further found that CSMD1-overexpression …
The Role of Csmd1 during Mammary Gland Development.
Burgess SJ, Gibbs H, Toomes C, Coletta PL, Bell SM. Burgess SJ, et al. Genes (Basel). 2021 Jan 26;12(2):162. doi: 10.3390/genes12020162. Genes (Basel). 2021. PMID: 33530646 Free PMC article.
CSMD1 knockdown in vitro demonstrated increased cell proliferation, invasion and motility. ...In this study a Csmd1 knockout (KO) mouse model was used to identify the role of Csmd1 in regulating mammary gland development during puberty. ...
CSMD1 knockdown in vitro demonstrated increased cell proliferation, invasion and motility. ...In this study a Csmd1 knockout ( …
CSMD1 Mutation Related to Immunity Can Be Used as a Marker to Evaluate the Clinical Therapeutic Effect and Prognosis of Patients with Esophageal Cancer.
Fan X, Song J, Fan Y, Li J, Chen Y, Zhu H, Zhang Z. Fan X, et al. Int J Gen Med. 2021 Nov 23;14:8689-8710. doi: 10.2147/IJGM.S338284. eCollection 2021. Int J Gen Med. 2021. PMID: 34849012 Free PMC article.
Paclitaxel sensitivity and ABCC1 expression were higher in the wild CSMD1 group. Most cancers show differential expression of CSMD1. ...Mutation and loss of CSMD1 may promote the progression of ESCA....
Paclitaxel sensitivity and ABCC1 expression were higher in the wild CSMD1 group. Most cancers show differential expression of CSMD …
Hypoxia induces hepatocellular carcinoma metastasis via the HIF-1alpha/METTL16/lnc-CSMD1-7/RBFOX2 axis.
Wang Y, Yang Y, Yang Y, Dang Y, Guo Z, Zhuang Q, Zheng X, Wang F, Cheng N, Liu X, Guo W, Zhao B. Wang Y, et al. iScience. 2023 Nov 19;26(12):108495. doi: 10.1016/j.isci.2023.108495. eCollection 2023 Dec 15. iScience. 2023. PMID: 38089592 Free PMC article.
Lnc-CSMD1-7 negatively regulated HCC cell migration and invasion in vitro and suppressed lung metastasis in vivo. ...More importantly, hypoxic microenvironment and m6A methylation mediate the downregulation of Lnc-CSMD1-7 expression. Specifically, hypoxia transcript …
Lnc-CSMD1-7 negatively regulated HCC cell migration and invasion in vitro and suppressed lung metastasis in vivo. ...More importantly …
CSMD1 Shows Complex Patterns of Somatic Copy Number Alterations and Expressions of mRNAs and Target Micro RNAs in Esophageal Squamous Cell Carcinoma.
Hu N, Wang C, Zhang T, Su H, Liu H, Yang HH, Giffen C, Hu Y, Taylor PR, Goldstein AM. Hu N, et al. Cancers (Basel). 2022 Oct 13;14(20):5001. doi: 10.3390/cancers14205001. Cancers (Basel). 2022. PMID: 36291785 Free PMC article.
(iii) In total, 68% of SNPs with a CNA were correlated with expression of CSMD1. (iv) A total of 33 correlations between non-coding SNPs and expression of CSMD1 target miRs were found. ...Alterations in some somatic SNPs in non-coding regions of CSMD1 appear …
(iii) In total, 68% of SNPs with a CNA were correlated with expression of CSMD1. (iv) A total of 33 correlations between non-coding S …
CSMD1 rs10503253 increases schizophrenia risk in a Tunisian population-group.
Mihoub O, Ben Chaaben A, Boukouaci W, Lajnef M, Ayari F, El Kefi H, Ben Ammar H, Abazza H, El Hechmi Z, Guemira F, Leboyer M, Tamouza R, Kharrat M. Mihoub O, et al. Encephale. 2023 Sep 23:S0013-7006(23)00146-X. doi: 10.1016/j.encep.2023.08.002. Online ahead of print. Encephale. 2023. PMID: 37748985
Recent genome-wide association studies have identified several at risk genetic variants, including two single nucleotide polymorphisms, namely the rs10503253 and the rs1270942 respectively located in the CSMD1 and the CFB loci. The present case-control study was designed t …
Recent genome-wide association studies have identified several at risk genetic variants, including two single nucleotide polymorphisms, name …
CSMD1 Mutations Are Associated with Increased Mutational Burden, Favorable Prognosis, and Anti-Tumor Immunity in Gastric Cancer.
Huang T, Liang Y, Zhang H, Chen X, Wei H, Sun W, Wang Y. Huang T, et al. Genes (Basel). 2021 Oct 28;12(11):1715. doi: 10.3390/genes12111715. Genes (Basel). 2021. PMID: 34828321 Free PMC article.
The genetic map showed that, compared with wild-type samples, the loss of chromosomes 4q, 5q, 8p, and 9p decreased and the status of microsatellite instability increased in the CSMD1-mut samples. The GSEA analysis showed that immune-related pathways were enriched in the …
The genetic map showed that, compared with wild-type samples, the loss of chromosomes 4q, 5q, 8p, and 9p decreased and the status of microsa …
Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer cells to chemotherapy.
Gialeli C, Tuysuz EC, Staaf J, Guleed S, Paciorek V, Mörgelin M, Papadakos KS, Blom AM. Gialeli C, et al. J Exp Clin Cancer Res. 2021 Aug 17;40(1):258. doi: 10.1186/s13046-021-02042-1. J Exp Clin Cancer Res. 2021. PMID: 34404439 Free PMC article.
BACKGROUND: Human CUB and Sushi multiple domains 1 (CSMD1) is a large membrane-bound tumor suppressor in breast cancer. ...We found altered expression of several cancer-related molecules, as well as diminished expression of signaling receptors including Epidermal Growth Fa …
BACKGROUND: Human CUB and Sushi multiple domains 1 (CSMD1) is a large membrane-bound tumor suppressor in breast cancer. ...We found a …
217 results