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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 1
1994 1
1995 1
1996 8
1997 23
1998 75
1999 92
2000 115
2001 155
2002 153
2003 198
2004 248
2005 308
2006 342
2007 427
2008 491
2009 514
2010 569
2011 641
2012 685
2013 673
2014 734
2015 723
2016 644
2017 639
2018 619
2019 616
2020 618
2021 583
2022 511
2023 477
2024 166

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10,661 results

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Page 1
Targeting CXCL12/CXCR4 Axis in Tumor Immunotherapy.
Zhou W, Guo S, Liu M, Burow ME, Wang G. Zhou W, et al. Curr Med Chem. 2019;26(17):3026-3041. doi: 10.2174/0929867324666170830111531. Curr Med Chem. 2019. PMID: 28875842 Free PMC article. Review.
Chemokines work in immune cells by trafficking and regulating cell proliferation, migration, activation, differentiation, and homing. CXCR-4 is an alpha-chemokine receptor specific for stromal-derived-factor-1 (SDF-1, also known as CXCL12), which has been found to b …
Chemokines work in immune cells by trafficking and regulating cell proliferation, migration, activation, differentiation, and homing. CXCR-4 …
CXCL12-CXCR4/CXCR7 Axis in Cancer: from Mechanisms to Clinical Applications.
Yang Y, Li J, Lei W, Wang H, Ni Y, Liu Y, Yan H, Tian Y, Wang Z, Yang Z, Yang S, Yang Y, Wang Q. Yang Y, et al. Int J Biol Sci. 2023 Jun 26;19(11):3341-3359. doi: 10.7150/ijbs.82317. eCollection 2023. Int J Biol Sci. 2023. PMID: 37497001 Free PMC article. Review.
Chemokines are a superfamily of small molecule chemoattractive cytokines that mediate a variety of cellular functions. Importantly, the interactions of chemokine members CXCL12 and its receptors CXCR4 and CXCR7 have a broad impact on tumor cell proliferation, surviv …
Chemokines are a superfamily of small molecule chemoattractive cytokines that mediate a variety of cellular functions. Importantly, the inte …
The unique structural and functional features of CXCL12.
Janssens R, Struyf S, Proost P. Janssens R, et al. Cell Mol Immunol. 2018 Apr;15(4):299-311. doi: 10.1038/cmi.2017.107. Epub 2017 Oct 30. Cell Mol Immunol. 2018. PMID: 29082918 Free PMC article. Review.
The CXC chemokine CXCL12 is an important factor in physiological and pathological processes, including embryogenesis, hematopoiesis, angiogenesis and inflammation, because it activates and/or induces migration of hematopoietic progenitor and stem cells, endothelial …
The CXC chemokine CXCL12 is an important factor in physiological and pathological processes, including embryogenesis, hematopo …
The chemokines CXCL8 and CXCL12: molecular and functional properties, role in disease and efforts towards pharmacological intervention.
Cambier S, Gouwy M, Proost P. Cambier S, et al. Cell Mol Immunol. 2023 Mar;20(3):217-251. doi: 10.1038/s41423-023-00974-6. Epub 2023 Feb 1. Cell Mol Immunol. 2023. PMID: 36725964 Free PMC article. Review.
CXCL8 activity inherently depends on interaction with the human CXC chemokine receptors CXCR1 and CXCR2, the atypical chemokine receptor ACKR1, and glycosaminoglycans. ...CXCL8-mediated neutrophil mobilization to blood is directly opposed by CXCL12, which ret …
CXCL8 activity inherently depends on interaction with the human CXC chemokine receptors CXCR1 and CXCR2, the atypical chemokine …
CXCL12/CXCR4 signal transduction in diseases and its molecular approaches in targeted-therapy.
Mousavi A. Mousavi A. Immunol Lett. 2020 Jan;217:91-115. doi: 10.1016/j.imlet.2019.11.007. Epub 2019 Nov 17. Immunol Lett. 2020. PMID: 31747563 Review.
CXCL12 is a homeostatic chemokine, which is acts as an anti-inflammatory chemokine during autoimmune inflammatory responses. In cancer cells, CXCL12 acts as an angiogenic, proliferative agent and regulates tumor cell apoptosis as well. ...
CXCL12 is a homeostatic chemokine, which is acts as an anti-inflammatory chemokine during autoimmune inflammatory respo …
Functions of the CXCL12 Receptor ACKR3/CXCR7-What Has Been Perceived and What Has Been Overlooked.
Koch C, Engele J. Koch C, et al. Mol Pharmacol. 2020 Nov;98(5):577-585. doi: 10.1124/molpharm.120.000056. Epub 2020 Sep 3. Mol Pharmacol. 2020. PMID: 32883765 Review.
This disease-associated role presently focuses major interest on the two CXCL12 receptors, CXCR4 and atypical chemokine receptor 3 (ACKR3)/CXCR7, as promising therapeutic targets. ...SIGNIFICANCE STATEMENT: Delineating the recognized functions of atypical chemoki …
This disease-associated role presently focuses major interest on the two CXCL12 receptors, CXCR4 and atypical chemokine recept …
CXCL12/CXCR4 axis in the microenvironment of solid tumors: A critical mediator of metastasis.
Mortezaee K. Mortezaee K. Life Sci. 2020 May 15;249:117534. doi: 10.1016/j.lfs.2020.117534. Epub 2020 Mar 7. Life Sci. 2020. PMID: 32156548 Review.
Tumors are dynamic tissue masses, so requiring continuous exposure to the host cells, nurturing them into pave a path for tumor growth and metastasis. C-X-C chemokine ligand 12 (CXCL12)/C-X-C chemokine receptor type 4 (CXCR4) is the key signaling for such aim …
Tumors are dynamic tissue masses, so requiring continuous exposure to the host cells, nurturing them into pave a path for tumor growth and m …
CXC chemokine ligand 12 (CXCL12) in atherosclerosis: An underlying therapeutic target.
Gao JH, Yu XH, Tang CK. Gao JH, et al. Clin Chim Acta. 2019 Aug;495:538-544. doi: 10.1016/j.cca.2019.05.022. Epub 2019 May 27. Clin Chim Acta. 2019. PMID: 31145896 Review.
CXC chemokine ligand 12 (CXCL12) is a specific chemokine ligand and plays a significant role in cell chemotaxis. Upon binding to CXC chemokine receptor 4 (CXCR4) or CXCR7, CXCL12 can activate different signaling cascades to regulate cell prolife …
CXC chemokine ligand 12 (CXCL12) is a specific chemokine ligand and plays a significant role in cell chemotaxis. Upon b …
Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1.
Zhang Z, Yu Y, Zhang Z, Li D, Liang Z, Wang L, Chen Y, Liang Y, Niu H. Zhang Z, et al. J Exp Clin Cancer Res. 2023 Nov 25;42(1):316. doi: 10.1186/s13046-023-02900-0. J Exp Clin Cancer Res. 2023. PMID: 38001512 Free PMC article.
METHODS: Bioinformatics analysis was performed to analyze the prognostic value of CAFs and CXCL12 using GEO, TCGA and SRA databases. The effects of CXCL12 on bladder cancer progression were investigated through in vitro and in vivo assays. ...Targeting CAFs-derived …
METHODS: Bioinformatics analysis was performed to analyze the prognostic value of CAFs and CXCL12 using GEO, TCGA and SRA databases. …
CXCL12/CXCR4 signalling in neuronal cell migration.
Tiveron MC, Cremer H. Tiveron MC, et al. Curr Opin Neurobiol. 2008 Jun;18(3):237-44. doi: 10.1016/j.conb.2008.06.004. Curr Opin Neurobiol. 2008. PMID: 18644448 Review.
The chemokine CXCL12 (or SDF-1) and its receptor CXCR4 have originally been described as regulators of cell interactions in the immune system. ...Furthermore, we will discuss these findings in light of the recently discovered second receptor for CXCL12, CXCR7 …
The chemokine CXCL12 (or SDF-1) and its receptor CXCR4 have originally been described as regulators of cell interactions in th …
10,661 results
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