Castration-mediated IL-8 promotes myeloid infiltration and prostate cancer progression.
Lopez-Bujanda ZA, Haffner MC, Chaimowitz MG, Chowdhury N, Venturini NJ, Patel RA, Obradovic A, Hansen CS, Jacków J, Maynard JP, Sfanos KS, Abate-Shen C, Bieberich CJ, Hurley PJ, Selby MJ, Korman AJ, Christiano AM, De Marzo AM, Drake CG.
Lopez-Bujanda ZA, et al.
Nat Cancer. 2021 Aug;2(8):803-818. doi: 10.1038/s43018-021-00227-3. Epub 2021 Jul 19.
Nat Cancer. 2021.
PMID: 35122025
Free PMC article.
We found that castration resulted in increased expression of interleukin-8 (IL-8) and its probable murine homolog Cxcl15 in prostate epithelial cells. We showed that these chemokines drove subsequent intratumoral infiltration of tumor-promoting polymorphonuclear myeloid-de …
We found that castration resulted in increased expression of interleukin-8 (IL-8) and its probable murine homolog Cxcl15 in prostate …