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Year Number of Results
1997 3
1998 3
1999 5
2000 9
2001 8
2002 7
2003 15
2004 9
2005 21
2006 20
2007 19
2008 36
2009 21
2010 27
2011 30
2012 33
2013 29
2014 33
2015 34
2016 45
2017 42
2018 40
2019 54
2020 49
2021 90
2022 84
2023 62
2024 28

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766 results

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Page 1
CXCR6 orchestrates brain CD8(+) T cell residency and limits mouse Alzheimer's disease pathology.
Su W, Saravia J, Risch I, Rankin S, Guy C, Chapman NM, Shi H, Sun Y, Kc A, Li W, Huang H, Lim SA, Hu H, Wang Y, Liu D, Jiao Y, Chen PC, Soliman H, Yan KK, Zhang J, Vogel P, Liu X, Serrano GE, Beach TG, Yu J, Peng J, Chi H. Su W, et al. Nat Immunol. 2023 Oct;24(10):1735-1747. doi: 10.1038/s41590-023-01604-z. Epub 2023 Sep 7. Nat Immunol. 2023. PMID: 37679549
Further, Cxcr6 deficiency impairs accumulation, tissue residency programming and clonal expansion of brain PD-1(+)CD8(+) T cells. Ablation of Cxcr6 or CD8(+) T cells ultimately increases proinflammatory cytokine production from microglia, with CXCR6 orchestra …
Further, Cxcr6 deficiency impairs accumulation, tissue residency programming and clonal expansion of brain PD-1(+)CD8(+) T cells. Abl …
CXCR6 expressing T cells: Functions and role in the control of tumors.
Mabrouk N, Tran T, Sam I, Pourmir I, Gruel N, Granier C, Pineau J, Gey A, Kobold S, Fabre E, Tartour E. Mabrouk N, et al. Front Immunol. 2022 Oct 12;13:1022136. doi: 10.3389/fimmu.2022.1022136. eCollection 2022. Front Immunol. 2022. PMID: 36311728 Free PMC article. Review.
CXCR6 is a receptor for the chemokine CXCL16, which exists as a membrane or soluble form. ...Mice deficient in cxcr6 or blocking the interaction of CXCR6 with its ligand, experience a poorer control of tumor proliferation by CD8(+) T cells, but also by NKT ce …
CXCR6 is a receptor for the chemokine CXCL16, which exists as a membrane or soluble form. ...Mice deficient in cxcr6 or blocki …
CXCR6 positions cytotoxic T cells to receive critical survival signals in the tumor microenvironment.
Di Pilato M, Kfuri-Rubens R, Pruessmann JN, Ozga AJ, Messemaker M, Cadilha BL, Sivakumar R, Cianciaruso C, Warner RD, Marangoni F, Carrizosa E, Lesch S, Billingsley J, Perez-Ramos D, Zavala F, Rheinbay E, Luster AD, Gerner MY, Kobold S, Pittet MJ, Mempel TR. Di Pilato M, et al. Cell. 2021 Aug 19;184(17):4512-4530.e22. doi: 10.1016/j.cell.2021.07.015. Epub 2021 Aug 2. Cell. 2021. PMID: 34343496 Free PMC article.
Here, we show that the conversion of stem-like into effector-like CTLs involves a major chemotactic reprogramming that includes the upregulation of chemokine receptor CXCR6. This receptor positions effector-like CTLs in a discrete perivascular niche of the tumor stroma tha …
Here, we show that the conversion of stem-like into effector-like CTLs involves a major chemotactic reprogramming that includes the upregula …
Auto-aggressive CXCR6(+) CD8 T cells cause liver immune pathology in NASH.
Dudek M, Pfister D, Donakonda S, Filpe P, Schneider A, Laschinger M, Hartmann D, Hüser N, Meiser P, Bayerl F, Inverso D, Wigger J, Sebode M, Öllinger R, Rad R, Hegenbarth S, Anton M, Guillot A, Bowman A, Heide D, Müller F, Ramadori P, Leone V, Garcia-Caceres C, Gruber T, Seifert G, Kabat AM, Mallm JP, Reider S, Effenberger M, Roth S, Billeter AT, Müller-Stich B, Pearce EJ, Koch-Nolte F, Käser R, Tilg H, Thimme R, Boettler T, Tacke F, Dufour JF, Haller D, Murray PJ, Heeren R, Zehn D, Böttcher JP, Heikenwälder M, Knolle PA. Dudek M, et al. Nature. 2021 Apr;592(7854):444-449. doi: 10.1038/s41586-021-03233-8. Epub 2021 Mar 24. Nature. 2021. PMID: 33762736
Liver CXCR6(+) CD8 T cells were characterized by low activity of the FOXO1 transcription factor, and were abundant in NASH mice and in patients with NASH. Mechanistically, IL-15 induced FOXO1 downregulation and CXCR6 upregulation, which together rendered liver-resid …
Liver CXCR6(+) CD8 T cells were characterized by low activity of the FOXO1 transcription factor, and were abundant in NASH mice and i …
Role of the CXCR6/CXCL16 axis in autoimmune diseases.
Bao N, Fu B, Zhong X, Jia S, Ren Z, Wang H, Wang W, Shi H, Li J, Ge F, Chang Q, Gong Y, Liu W, Qiu F, Xu S, Li T. Bao N, et al. Int Immunopharmacol. 2023 Aug;121:110530. doi: 10.1016/j.intimp.2023.110530. Epub 2023 Jun 20. Int Immunopharmacol. 2023. PMID: 37348231 Review.
The C-X-C motif ligand 16, or CXCL16, is a chemokine that belongs to the ELR - CXC subfamily. Its function is to bind to the chemokine receptor CXCR6, which is a G protein-coupled receptor with 7 transmembrane domains. ...Further investigation is required to comprehend the …
The C-X-C motif ligand 16, or CXCL16, is a chemokine that belongs to the ELR - CXC subfamily. Its function is to bind to the chemokine recep …
CXCR6 is required for antitumor efficacy of intratumoral CD8(+) T cell.
Wang B, Wang Y, Sun X, Deng G, Huang W, Wu X, Gu Y, Tian Z, Fan Z, Xu Q, Chen H, Sun Y. Wang B, et al. J Immunother Cancer. 2021 Aug;9(8):e003100. doi: 10.1136/jitc-2021-003100. J Immunother Cancer. 2021. PMID: 34462326 Free PMC article.
Transgenic Cxcr6(-/-) OT-I mice were employed to explore the functional role of CXCR6 in antigen-specific antitumor response. ...High tumor expression of CXCR6 was not mainly caused by ligand-receptor chemotaxis of CXCL16/CXCR6 but induced by tumor tis …
Transgenic Cxcr6(-/-) OT-I mice were employed to explore the functional role of CXCR6 in antigen-specific antitumor response. …
The role of the CXCR6/CXCL16 axis in the pathogenesis of fibrotic disease.
Wang FT, Wu TQ, Lin Y, Jiao YR, Li JY, Ruan Y, Yin L, Chen CQ. Wang FT, et al. Int Immunopharmacol. 2024 May 10;132:112015. doi: 10.1016/j.intimp.2024.112015. Epub 2024 Apr 11. Int Immunopharmacol. 2024. PMID: 38608478 Review.
Soluble CXCL16 (sCXCL16) serves as a chemokine, facilitating the migration and recruitment of CXCR6-expressing cells, while membrane-bound CXCL16 (mCXCL16) functions as a transmembrane protein with adhesion properties, facilitating intercellular interactions by binding to …
Soluble CXCL16 (sCXCL16) serves as a chemokine, facilitating the migration and recruitment of CXCR6-expressing cells, while membrane- …
The Role of CXCR1, CXCR2, CXCR3, CXCR5, and CXCR6 Ligands in Molecular Cancer Processes and Clinical Aspects of Acute Myeloid Leukemia (AML).
Korbecki J, Kupnicka P, Barczak K, Bosiacki M, Ziętek P, Chlubek D, Baranowska-Bosiacka I. Korbecki J, et al. Cancers (Basel). 2023 Sep 14;15(18):4555. doi: 10.3390/cancers15184555. Cancers (Basel). 2023. PMID: 37760523 Free PMC article. Review.
This study aims to bridge that gap by providing an overview of the significance of CXC chemokines other than CXCL12 (CXCR1, CXCR2, CXCR3, CXCR5, and CXCR6 ligands and CXCL14 and CXCL17) in AML's oncogenic processes. ...
This study aims to bridge that gap by providing an overview of the significance of CXC chemokines other than CXCL12 (CXCR1, CXCR2, CXCR3, CX …
CXCR6/CXCL16 functions as a regulator in metastasis and progression of cancer.
Deng L, Chen N, Li Y, Zheng H, Lei Q. Deng L, et al. Biochim Biophys Acta. 2010 Aug;1806(1):42-9. doi: 10.1016/j.bbcan.2010.01.004. Epub 2010 Feb 1. Biochim Biophys Acta. 2010. PMID: 20122997 Review.
CXCR6 and CXCL16 are up-regulated in multiple cancer tissue types and cancer cell lines relative to normal tissues and cell lines. ...Moreover, the Akt/mTOR signal pathway is involved in activating the CXCR6/CXCL16 axis. These findings suggest multiple opportunities …
CXCR6 and CXCL16 are up-regulated in multiple cancer tissue types and cancer cell lines relative to normal tissues and cell lines. .. …
CXCR6: the role of environment in tumor progression. Challenges for therapy.
La Porta CA. La Porta CA. Stem Cell Rev Rep. 2012 Dec;8(4):1282-5. doi: 10.1007/s12015-012-9383-6. Stem Cell Rev Rep. 2012. PMID: 22678828 Review.
The role of chemokines in tumor progression is an essential event that leads to homing and metastasis of tumor cells in a receptor-dependent, organ specific manner. In recent years, the involvement of CXCR6 and its ligand CXCL16 in tumor progression is becoming more eviden …
The role of chemokines in tumor progression is an essential event that leads to homing and metastasis of tumor cells in a receptor-dependent …
766 results