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Page 1
CDK9: a signaling hub for transcriptional control.
Bacon CW, D'Orso I. Bacon CW, et al. Transcription. 2019 Apr;10(2):57-75. doi: 10.1080/21541264.2018.1523668. Epub 2018 Oct 11. Transcription. 2019. PMID: 30227759 Free PMC article. Review.
Abbreviations: CDK: Cyclin-dependent kinase; Pol II: RNA Polymerase II; PIC: Pre-initiation Complex; TFIIH: Transcription Factor-II H; snoRNA: small nucleolar RNA; CycT: CyclinT1/T2; P-TEFb: Positive Transcription Elongation Factor Complex; snRNP: small nuclear ribonucleo- …
Abbreviations: CDK: Cyclin-dependent kinase; Pol II: RNA Polymerase II; PIC: Pre-initiation Complex; TFIIH: Transcription Factor-II H; snoRN …
Tumor shrinkage by cyclopamine tartrate through inhibiting hedgehog signaling.
Fan Q, Gu D, He M, Liu H, Sheng T, Xie G, Li CX, Zhang X, Wainwright B, Garrossian A, Garrossian M, Gardner D, Xie J. Fan Q, et al. Chin J Cancer. 2011 Jul;30(7):472-81. doi: 10.5732/cjc.011.10157. Chin J Cancer. 2011. PMID: 21718593 Free PMC article.
Unlike Cyc, CycT is water soluble (5-10 mg/mL). The median lethal dose (LD50) of CycT was 62.5 mg/kg body weight compared to 43.5 mg/kg for Cyc, and the plasma half-life (T1/2) of CycT was not significantly different from that of Cyc. We showed that CycT …
Unlike Cyc, CycT is water soluble (5-10 mg/mL). The median lethal dose (LD50) of CycT was 62.5 mg/kg body weight compared to 4 …
Oxygen-Enhanced Optoacoustic Tomography Reveals the Effectiveness of Targeting Heme and Oxidative Phosphorylation at Normalizing Tumor Vascular Oxygenation.
Ghosh P, Guo Y, Ashrafi A, Chen J, Dey S, Zhong S, Liu J, Campbell J, Konduri PC, Gerberich J, Garrossian M, Mason RP, Zhang L, Liu L. Ghosh P, et al. Cancer Res. 2020 Sep 1;80(17):3542-3555. doi: 10.1158/0008-5472.CAN-19-3247. Epub 2020 Jun 16. Cancer Res. 2020. PMID: 32546631 Free PMC article.
HSP2 and CycT can inhibit ATP generation and thereby suppress NSCLC cell tumorigenic functions. ...HSP2 and CycT normalized tumor vasculature and improved tumor oxygenation, where levels of several hypoxia markers in NSCLC tumors were reduced by treatment with HSP2 …
HSP2 and CycT can inhibit ATP generation and thereby suppress NSCLC cell tumorigenic functions. ...HSP2 and CycT normalized tu …
Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression.
Kalainayakan SP, Ghosh P, Dey S, Fitzgerald KE, Sohoni S, Konduri PC, Garrossian M, Liu L, Zhang L. Kalainayakan SP, et al. Sci Rep. 2019 Feb 5;9(1):1405. doi: 10.1038/s41598-018-38345-1. Sci Rep. 2019. PMID: 30723259 Free PMC article.
CycT reduces heme synthesis and degradation in NSCLC cells and suppresses oxygen consumption in purified mitochondria. ...CycT also decreases the levels of two regulators promoting OXPHOS, MYC and MCL1, and effectively alleviates tumor hypoxia. ...
CycT reduces heme synthesis and degradation in NSCLC cells and suppresses oxygen consumption in purified mitochondria. ...CycT …
Cyclopamine tartrate, an inhibitor of Hedgehog signaling, strongly interferes with mitochondrial function and suppresses aerobic respiration in lung cancer cells.
Alam MM, Sohoni S, Kalainayakan SP, Garrossian M, Zhang L. Alam MM, et al. BMC Cancer. 2016 Feb 24;16:150. doi: 10.1186/s12885-016-2200-x. BMC Cancer. 2016. PMID: 26911235 Free PMC article.
METHODS: The effect of CycT on oxygen consumption and proliferation of non-small-cell lung cancer (NSCLC) cell lines was quantified by using an Oxygraph system and live cell counting, respectively. ...Further, we found that CycT increased ROS generation, mitochondri …
METHODS: The effect of CycT on oxygen consumption and proliferation of non-small-cell lung cancer (NSCLC) cell lines was quantified b …
An alternative D. melanogaster 7SK snRNP.
Nguyen D, Buisine N, Fayol O, Michels AA, Bensaude O, Price DH, Uguen P. Nguyen D, et al. BMC Mol Cell Biol. 2021 Aug 31;22(1):43. doi: 10.1186/s12860-021-00381-7. BMC Mol Cell Biol. 2021. PMID: 34461828 Free PMC article.
The Medicago CDKC;1-CYCLINT;1 kinase complex phosphorylates the carboxy-terminal domain of RNA polymerase II and promotes transcription.
Fülöp K, Pettkó-Szandtner A, Magyar Z, Miskolczi P, Kondorosi E, Dudits D, Bakó L. Fülöp K, et al. Plant J. 2005 Jun;42(6):810-20. doi: 10.1111/j.1365-313X.2005.02421.x. Plant J. 2005. PMID: 15941395 Free article.
Furthermore, our data show that addition of the Medicago CDKC;1-CYCT;1 heterodimer completely restored the transcriptional activity of a HeLa nuclear extract depleted of endogeneous CDK9 kinase complexes. Together, these results indicate that the Medicago CDKC;1-CYCT …
Furthermore, our data show that addition of the Medicago CDKC;1-CYCT;1 heterodimer completely restored the transcriptional activity o …
AFF1 is a ubiquitous P-TEFb partner to enable Tat extraction of P-TEFb from 7SK snRNP and formation of SECs for HIV transactivation.
Lu H, Li Z, Xue Y, Schulze-Gahmen U, Johnson JR, Krogan NJ, Alber T, Zhou Q. Lu H, et al. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):E15-24. doi: 10.1073/pnas.1318503111. Epub 2013 Dec 23. Proc Natl Acad Sci U S A. 2014. PMID: 24367103 Free PMC article.
These complexes have been thought to share no components other than the core P-TEFb subunits cyclin-dependent kinase 9 (CDK9) and cyclin T (CycT, T1, T2a, and T2b). Here we show that the AF4/FMR2 family member 1 (AFF1) is bound to CDK9-CycT and is present in all maj …
These complexes have been thought to share no components other than the core P-TEFb subunits cyclin-dependent kinase 9 (CDK9) and cyclin T ( …
Anti-apoptotic Regulation Contributes to the Successful Nuclear Reprogramming Using Cryopreserved Oocytes.
Lee AR, Hong K, Choi SH, Park C, Park JK, Lee JI, Bang JI, Seol DW, Lee JE, Lee DR. Lee AR, et al. Stem Cell Reports. 2019 Mar 5;12(3):545-556. doi: 10.1016/j.stemcr.2019.01.019. Epub 2019 Feb 21. Stem Cell Reports. 2019. PMID: 30799275 Free PMC article.
Using RNA-sequencing analysis, we found upregulation of eight pro-apoptotic-related genes (Cyct, Dapk2, Dffb, Gadd45g, Hint2, Mien1, P2rx7, and Pmaip) in the SCNT-CROC group. ...
Using RNA-sequencing analysis, we found upregulation of eight pro-apoptotic-related genes (Cyct, Dapk2, Dffb, Gadd45g, Hint2, Mien1, …
Increased expression of the rice C-type cyclin-dependent protein kinase gene, Orysa;CDKC;1, in response to salt stress.
Huang YW, Tsay WS, Chen CC, Lin CW, Huang HJ. Huang YW, et al. Plant Physiol Biochem. 2008 Jan;46(1):71-81. doi: 10.1016/j.plaphy.2007.10.013. Epub 2007 Oct 18. Plant Physiol Biochem. 2008. PMID: 18054244
This indicated a putative role during later stages of leaf and panicle development. Using yeast two-hybrid analysis, we identified Orysa;CYCT as an interactor with Orysa;CDKC;1. The expression profiles of the new Orysa;CDKC;1 in response to various factors from rice cells …
This indicated a putative role during later stages of leaf and panicle development. Using yeast two-hybrid analysis, we identified Orysa; …
34 results