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2000 1
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2008 1
2010 2
2011 4
2012 4
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2014 2
2015 3
2016 6
2017 3
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2019 5
2020 5
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2023 11
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Page 1
Protein Cytl1: its role in chondrogenesis, cartilage homeostasis, and disease.
Zhu S, Kuek V, Bennett S, Xu H, Rosen V, Xu J. Zhu S, et al. Cell Mol Life Sci. 2019 Sep;76(18):3515-3523. doi: 10.1007/s00018-019-03137-x. Epub 2019 May 14. Cell Mol Life Sci. 2019. PMID: 31089746 Free PMC article. Review.
In addition, Cytl1 exhibits chemotactic and pro-angiogenic biological effects. ...Defining the molecular structure of Cytl1 and its role in disease pathogenesis will help us to design therapeutic approaches for Cytl1-associated pathological conditions....
In addition, Cytl1 exhibits chemotactic and pro-angiogenic biological effects. ...Defining the molecular structure of Cytl1 an …
CYTL1 inhibits tumor metastasis with decreasing STAT3 phosphorylation.
Wang X, Li T, Cheng Y, Wang P, Yuan W, Liu Q, Yang F, Liu Q, Ma D, Ding S, Wang J, Han W. Wang X, et al. Oncoimmunology. 2019 Feb 18;8(5):e1577126. doi: 10.1080/2162402X.2019.1577126. eCollection 2019. Oncoimmunology. 2019. PMID: 31069137 Free PMC article.
CYTL1 is a novel cytokine that was first identified in CD34(+) hematopoietic cells. ...After validating the expression of CYTL1 in lung cancer, we identified that CYTL1 exerted no obvious effect on tumor cell proliferation but inhibited their migration and in …
CYTL1 is a novel cytokine that was first identified in CD34(+) hematopoietic cells. ...After validating the expression of CYTL1 …
CYTL1 Promotes the Activation of Neutrophils in a Sepsis Model.
Xue H, Li S, Zhao X, Guo F, Jiang L, Wang Y, Zhu F. Xue H, et al. Inflammation. 2020 Feb;43(1):274-285. doi: 10.1007/s10753-019-01116-9. Inflammation. 2020. PMID: 31823178
In this study, we found that expression of CYTL1 was upregulated in neutrophils upon inflammatory stimuli. We demonstrated that CYTL1 enhanced phagocytosis of Escherichia coli by activated neutrophils both in vivo and in vitro through phosphorylation of protein kina …
In this study, we found that expression of CYTL1 was upregulated in neutrophils upon inflammatory stimuli. We demonstrated that CY …
Intracellular CYTL1, a novel tumor suppressor, stabilizes NDUFV1 to inhibit metabolic reprogramming in breast cancer.
Xue W, Li X, Li W, Wang Y, Jiang C, Zhou L, Gao J, Yu Y, Shen Y, Xu Q. Xue W, et al. Signal Transduct Target Ther. 2022 Feb 4;7(1):35. doi: 10.1038/s41392-021-00856-1. Signal Transduct Target Ther. 2022. PMID: 35115484 Free PMC article.
Here, we demonstrate that intracellular cytokine-like protein 1 (CYTL1) plays a key role in preventing the robust glycolytic switching characteristic of breast cancer. A low intracellular CYTL1 level, not its mutation, is required for metabolic reprogramming. ...
Here, we demonstrate that intracellular cytokine-like protein 1 (CYTL1) plays a key role in preventing the robust glycolytic switchin …
CYTL1 regulates bone homeostasis in mice by modulating osteogenesis of mesenchymal stem cells and osteoclastogenesis of bone marrow-derived macrophages.
Shin Y, Won Y, Yang JI, Chun JS. Shin Y, et al. Cell Death Dis. 2019 Jan 18;10(2):47. doi: 10.1038/s41419-018-1284-4. Cell Death Dis. 2019. PMID: 30718470 Free PMC article.
Here, we investigated the potential functions of CYTL1 in bone homeostasis. We found that Cytl1(-/-) mice exhibited higher bone mass than wild-type littermates and resisted ovariectomy-induced bone resorption. ...The osteogenesis of hMSCs was inhibited by overexpres …
Here, we investigated the potential functions of CYTL1 in bone homeostasis. We found that Cytl1(-/-) mice exhibited higher bon …
A novel necroptosis-related gene index for predicting prognosis and a cold tumor immune microenvironment in stomach adenocarcinoma.
Khan M, Lin J, Wang B, Chen C, Huang Z, Tian Y, Yuan Y, Bu J. Khan M, et al. Front Immunol. 2022 Oct 27;13:968165. doi: 10.3389/fimmu.2022.968165. eCollection 2022. Front Immunol. 2022. PMID: 36389725 Free PMC article. Review.
The NRGPI-high subgroup was characterized by upregulation of 10 genes (CYTL1, PLCL1, CGB5, CNTN1, GRP, APOD, CST6, GPX3, FCN1, SERPINE1) and downregulation of 3 genes (EFNA3, E2F2, SOX14). ...These molecular characteristics were mainly driven by the eight NRGPI oncogenes ( …
The NRGPI-high subgroup was characterized by upregulation of 10 genes (CYTL1, PLCL1, CGB5, CNTN1, GRP, APOD, CST6, GPX3, FCN1, SERPIN …
Cytokine-Like Protein 1 (CYTL1) as a Key Target of M-Stage Immune Infiltration in Stomach Adenocarcinoma.
Zhou F, Lin Q, Zheng Z. Zhou F, et al. Biomed Res Int. 2023 Feb 13;2023:2926218. doi: 10.1155/2023/2926218. eCollection 2023. Biomed Res Int. 2023. PMID: 36825034 Free PMC article.
RESULTS: In our research, low CYTL1 expression (tumor vs. normal) was noted in patients with STAD. ...GSEA of the differential genes of CYTL1 showed the possible involvement of immunity. ssGSEA and estimation algorithms were used to further evaluate whether immune c …
RESULTS: In our research, low CYTL1 expression (tumor vs. normal) was noted in patients with STAD. ...GSEA of the differential genes …
The involvement of cytokine-like 1 (Cytl1) in chondrogenesis and cartilage metabolism.
Zhu W, Yang X, Liu S, Wang M, Ye S, Luo H, Cui S. Zhu W, et al. Biochem Biophys Res Commun. 2020 Aug 27;529(3):608-614. doi: 10.1016/j.bbrc.2020.06.069. Epub 2020 Jul 17. Biochem Biophys Res Commun. 2020. PMID: 32736681
Here, we show the involvement of Cytl1 in chondrogenesis. Using specified chondrogenic embryonic skeleton and adult cartilage, the Cytl1 gene expression was investigated with associated chondrogenic factors by quantitative RT-PCR. ...The results revealed that Cyt …
Here, we show the involvement of Cytl1 in chondrogenesis. Using specified chondrogenic embryonic skeleton and adult cartilage, the …
Cytokine-Like Protein 1(Cytl1): A Potential Molecular Mediator in Embryo Implantation.
Ai Z, Jing W, Fang L. Ai Z, et al. PLoS One. 2016 Jan 22;11(1):e0147424. doi: 10.1371/journal.pone.0147424. eCollection 2016. PLoS One. 2016. PMID: 26800213 Free PMC article.
However, our knowledge of Cytl1 is still limited. Here, we determined the Cytl1 expression pattern regulated by ovarian hormones at both the mRNA and protein levels. ...This study suggests that Cytl1 plays an active role in the regulation of embryo implantati …
However, our knowledge of Cytl1 is still limited. Here, we determined the Cytl1 expression pattern regulated by ovarian hormon …
Bioinformatics-based analysis reveals elevated CYTL1 as a potential therapeutic target for BRAF-mutated melanoma.
Tao L, Cui Y, Sun J, Cao Y, Dai Z, Ge X, Zhang L, Ma R, Liu Y. Tao L, et al. Front Cell Dev Biol. 2023 Sep 6;11:1171047. doi: 10.3389/fcell.2023.1171047. eCollection 2023. Front Cell Dev Biol. 2023. PMID: 37745303 Free PMC article.
By knocking down CYTL1 in melanoma cells, the effects of CYTL1 on melanoma cell proliferation, migration and invasion were further examined by CCK8 assay, Transwell assay and cell migration assay. ...In vitro experiments further confirmed that the knockdown of CY …
By knocking down CYTL1 in melanoma cells, the effects of CYTL1 on melanoma cell proliferation, migration and invasion were fur …
60 results