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Independent generation of Abeta42 and Abeta38 peptide species by gamma-secretase.
Czirr E, Cottrell BA, Leuchtenberger S, Kukar T, Ladd TB, Esselmann H, Paul S, Schubenel R, Torpey JW, Pietrzik CU, Golde TE, Wiltfang J, Baumann K, Koo EH, Weggen S. Czirr E, et al. J Biol Chem. 2008 Jun 20;283(25):17049-54. doi: 10.1074/jbc.M802912200. Epub 2008 Apr 21. J Biol Chem. 2008. PMID: 18426795 Free article.
Presenilin-1 but not amyloid precursor protein mutations present in mouse models of Alzheimer's disease attenuate the response of cultured cells to γ-secretase modulators regardless of their potency and structure.
Hahn S, Brüning T, Ness J, Czirr E, Baches S, Gijsen H, Korth C, Pietrzik CU, Bulic B, Weggen S. Hahn S, et al. Among authors: czirr e. J Neurochem. 2011 Feb;116(3):385-95. doi: 10.1111/j.1471-4159.2010.07118.x. Epub 2010 Dec 13. J Neurochem. 2011. PMID: 21091478 Free article.
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis.
Kleinberger G, Yamanishi Y, Suárez-Calvet M, Czirr E, Lohmann E, Cuyvers E, Struyfs H, Pettkus N, Wenninger-Weinzierl A, Mazaheri F, Tahirovic S, Lleó A, Alcolea D, Fortea J, Willem M, Lammich S, Molinuevo JL, Sánchez-Valle R, Antonell A, Ramirez A, Heneka MT, Sleegers K, van der Zee J, Martin JJ, Engelborghs S, Demirtas-Tatlidede A, Zetterberg H, Van Broeckhoven C, Gurvit H, Wyss-Coray T, Hardy J, Colonna M, Haass C. Kleinberger G, et al. Among authors: czirr e. Sci Transl Med. 2014 Jul 2;6(243):243ra86. doi: 10.1126/scitranslmed.3009093. Sci Transl Med. 2014. PMID: 24990881
Preclinical Assessment of Young Blood Plasma for Alzheimer Disease.
Middeldorp J, Lehallier B, Villeda SA, Miedema SS, Evans E, Czirr E, Zhang H, Luo J, Stan T, Mosher KI, Masliah E, Wyss-Coray T. Middeldorp J, et al. Among authors: czirr e. JAMA Neurol. 2016 Nov 1;73(11):1325-1333. doi: 10.1001/jamaneurol.2016.3185. JAMA Neurol. 2016. PMID: 27598869 Free PMC article.
The immunology of neurodegeneration.
Czirr E, Wyss-Coray T. Czirr E, et al. J Clin Invest. 2012 Apr;122(4):1156-63. doi: 10.1172/JCI58656. Epub 2012 Apr 2. J Clin Invest. 2012. PMID: 22466657 Free PMC article. Review.
22 results