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Discovery of dachshund 2 protein as a novel biomarker of poor prognosis in epithelial ovarian cancer.
Nodin B, Fridberg M, Uhlén M, Jirström K. Nodin B, et al. J Ovarian Res. 2012 Jan 27;5(1):6. doi: 10.1186/1757-2215-5-6. J Ovarian Res. 2012. PMID: 22284433 Free PMC article.
Using the Human Protein Atlas as a tool for cancer biomarker discovery, DACH2 protein was found to be differentially expressed in epithelial ovarian cancer (EOC). Here, the expression and prognostic significance of DACH2 was further evaluated in ovaria …
Using the Human Protein Atlas as a tool for cancer biomarker discovery, DACH2 protein was found to be differentially expressed …
Prospective validation of DACH2 as a novel biomarker for prediction of metastasis and prognosis in muscle-invasive urothelial carcinoma of the bladder.
He YD, Luo ZH, Yang M, Ruan XX, Liu SY, Wu ZQ, Deng WM, Shao CK, Su ZL, He D, Gao X, Li LY. He YD, et al. Biochem Biophys Res Commun. 2015 Apr 10;459(3):416-23. doi: 10.1016/j.bbrc.2015.02.119. Epub 2015 Mar 2. Biochem Biophys Res Commun. 2015. PMID: 25744029
For the independent validation set (n = 243), patients with primary UCB that did not express DACH2 had a longer metastasis-free survival (MFS) and overall survival (OS) than did those with tumors expressing DACH2 (5-year MFS: 88% [95% CI 80-96] versus 19% [95% CI 7- …
For the independent validation set (n = 243), patients with primary UCB that did not express DACH2 had a longer metastasis-free survi …
Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer.
Ishaque N, Abba ML, Hauser C, Patil N, Paramasivam N, Huebschmann D, Leupold JH, Balasubramanian GP, Kleinheinz K, Toprak UH, Hutter B, Benner A, Shavinskaya A, Zhou C, Gu Z, Kerssemakers J, Marx A, Moniuszko M, Kozlowski M, Reszec J, Niklinski J, Eils J, Schlesner M, Eils R, Brors B, Allgayer H. Ishaque N, et al. Nat Commun. 2018 Nov 14;9(1):4782. doi: 10.1038/s41467-018-07041-z. Nat Commun. 2018. PMID: 30429477 Free PMC article.
Recurrently mutated non-coding elements include ncRNAs RP11-594N15.3, AC010091, SNHG14, 3' UTRs of FOXP2, DACH2, TRPM3, XKR4, ANO5, CBL, CBLB, the latter four potentially dual protagonists in metastasis and efferocytosis-/PD-L1 mediated immunosuppression. ...
Recurrently mutated non-coding elements include ncRNAs RP11-594N15.3, AC010091, SNHG14, 3' UTRs of FOXP2, DACH2, TRPM3, XKR4, ANO5, C …
The Dachshund gene in development and hormone-responsive tumorigenesis.
Popov VM, Wu K, Zhou J, Powell MJ, Mardon G, Wang C, Pestell RG. Popov VM, et al. Trends Endocrinol Metab. 2010 Jan;21(1):41-9. doi: 10.1016/j.tem.2009.08.002. Epub 2009 Nov 5. Trends Endocrinol Metab. 2010. PMID: 19896866 Free PMC article. Review.
Recent studies have demonstrated an important role for human Dachshund homologue (DACH1) in tumorigenesis, in particular, breast, prostate and ovarian cancer. The molecular mechanisms by which DACH1 regulates differentiation and tumorigenesis are discussed herein....
Recent studies have demonstrated an important role for human Dachshund homologue (DACH1) in tumorigenesis, in particular, breast, prostate a …
PAX5 fusion genes are frequent in poor risk childhood acute lymphoblastic leukaemia and can be targeted with BIBF1120.
Fazio G, Bresolin S, Silvestri D, Quadri M, Saitta C, Vendramini E, Buldini B, Palmi C, Bardini M, Grioni A, Rigamonti S, Galbiati M, Mecca S, Savino AM, Peloso A, Tu JW, Bhatia S, Borkhardt A, Micalizzi C, Lo Nigro L, Locatelli F, Conter V, Rizzari C, Valsecchi MG, Te Kronnie G, Biondi A, Cazzaniga G. Fazio G, et al. EBioMedicine. 2022 Sep;83:104224. doi: 10.1016/j.ebiom.2022.104224. Epub 2022 Aug 16. EBioMedicine. 2022. PMID: 35985167 Free PMC article.
Interestingly, PAX5 was altered in 54.4% of Ph-like compared to 16.2% of non-Ph-like cases, with 7 patients carrying PAX5 fusions (PAX5t), involving either novel (ALDH18A1, IKZF1, CDH13) or known (FBRSL1, AUTS2, DACH2) partner genes. PAX5t cases have a specific driver acti …
Interestingly, PAX5 was altered in 54.4% of Ph-like compared to 16.2% of non-Ph-like cases, with 7 patients carrying PAX5 fusions (PAX5t), i …
DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.
Wu K, Yang Y, Wang C, Davoli MA, D'Amico M, Li A, Cveklova K, Kozmik Z, Lisanti MP, Russell RG, Cvekl A, Pestell RG. Wu K, et al. J Biol Chem. 2003 Dec 19;278(51):51673-84. doi: 10.1074/jbc.M310021200. Epub 2003 Oct 2. J Biol Chem. 2003. PMID: 14525983 Free article.
The vertebrate homologues of Drosophila dachsund, DACH1 and DACH2, have been implicated as important regulatory genes in development. DACH1 plays a role in retinal and pituitary precursor cell proliferation and DACH2 plays a specific role in myogenesis. DACH protein …
The vertebrate homologues of Drosophila dachsund, DACH1 and DACH2, have been implicated as important regulatory genes in development. …
The histone deacetylase HDAC4 connects neural activity to muscle transcriptional reprogramming.
Cohen TJ, Waddell DS, Barrientos T, Lu Z, Feng G, Cox GA, Bodine SC, Yao TP. Cohen TJ, et al. J Biol Chem. 2007 Nov 16;282(46):33752-33759. doi: 10.1074/jbc.M706268200. Epub 2007 Sep 16. J Biol Chem. 2007. PMID: 17873280 Free article.
We determined that HDAC4 executes activity-dependent transcription by regulating the Dach2-myogenin transcriptional cascade where inhibition of the repressor Dach2 by HDAC4 permits the induction of the transcription factor myogenin, which in turn activates synaptic …
We determined that HDAC4 executes activity-dependent transcription by regulating the Dach2-myogenin transcriptional cascade where inh …
Transcriptional differences between normal and glioma-derived glial progenitor cells identify a core set of dysregulated genes.
Auvergne RM, Sim FJ, Wang S, Chandler-Militello D, Burch J, Al Fanek Y, Davis D, Benraiss A, Walter K, Achanta P, Johnson M, Quinones-Hinojosa A, Natesan S, Ford HL, Goldman SA. Auvergne RM, et al. Cell Rep. 2013 Jun 27;3(6):2127-41. doi: 10.1016/j.celrep.2013.04.035. Epub 2013 May 30. Cell Rep. 2013. PMID: 23727239 Free PMC article.
A core set of genes and pathways was substantially dysregulated in A2B5+ TPCs, which included the transcription factor SIX1 and its principal cofactors, EYA1 and DACH2. Small hairpin RNAi silencing of SIX1 inhibited the expansion of glioma TPCs in vitro and in vivo, sugges …
A core set of genes and pathways was substantially dysregulated in A2B5+ TPCs, which included the transcription factor SIX1 and its principa …
Fbxw7β is an inducing mediator of dexamethasone-induced skeletal muscle atrophy in vivo with the axis of Fbxw7β-myogenin-atrogenes.
Shin K, Ko YG, Jeong J, Kwon H. Shin K, et al. Mol Biol Rep. 2018 Aug;45(4):625-631. doi: 10.1007/s11033-018-4185-9. Epub 2018 Apr 18. Mol Biol Rep. 2018. PMID: 29671242
Also, muscle atrophy was associated with the Fbxw7beta-myogenin-atrogene axis and the down-regulation of Dach2, a repressor of myogenin. Taken together, these results suggest that the ubiquitin E3 ligase Fbxw7beta and the Fbxw7beta-myogenin-atrogene axis have important rol …
Also, muscle atrophy was associated with the Fbxw7beta-myogenin-atrogene axis and the down-regulation of Dach2, a repressor of myogen …
Functional heterogeneity of PAX5 chimeras reveals insight for leukemia development.
Fortschegger K, Anderl S, Denk D, Strehl S. Fortschegger K, et al. Mol Cancer Res. 2014 Apr;12(4):595-606. doi: 10.1158/1541-7786.MCR-13-0337. Epub 2014 Jan 16. Mol Cancer Res. 2014. PMID: 24435167
To gain mechanistic insight into the role of PAX5 fusion proteins in leukemogenesis, the biochemical and functional properties of uncharacterized fusions: PAX5-DACH1, PAX5-DACH2, PAX5-ETV6, PAX5-HIPK1, and PAX5-POM121 were ascertained. Independent of the subcellular distri …
To gain mechanistic insight into the role of PAX5 fusion proteins in leukemogenesis, the biochemical and functional properties of uncharacte …
11 results