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Page 1
Emerging Roles of DDB2 in Cancer.
Gilson P, Drouot G, Witz A, Merlin JL, Becuwe P, Harlé A. Gilson P, et al. Int J Mol Sci. 2019 Oct 18;20(20):5168. doi: 10.3390/ijms20205168. Int J Mol Sci. 2019. PMID: 31635251 Free PMC article. Review.
Recently, the potential of DDB2 in the development and progression of various cancers has been described. ...We also provide insights into the clinical consequences of DDB2 activity in cancers....
Recently, the potential of DDB2 in the development and progression of various cancers has been described. ...We also provide i …
DDB2 represses ovarian cancer cell dedifferentiation by suppressing ALDH1A1.
Cui T, Srivastava AK, Han C, Wu D, Wani N, Liu L, Gao Z, Qu M, Zou N, Zhang X, Yi P, Yu J, Bell EH, Yang SM, Maloney DJ, Zheng Y, Wani AA, Wang QE. Cui T, et al. Cell Death Dis. 2018 May 1;9(5):561. doi: 10.1038/s41419-018-0585-y. Cell Death Dis. 2018. PMID: 29752431 Free PMC article.
Cancer stem cells (CSCs), representing the root of many solid tumors including ovarian cancer, have been implicated in disease recurrence, metastasis, and therapeutic resistance. Our previous study has demonstrated that the CSC subpopulation in ovarian cancer …
Cancer stem cells (CSCs), representing the root of many solid tumors including ovarian cancer, have been implicated in disease …
DDB2 suppresses tumorigenicity by limiting the cancer stem cell population in ovarian cancer.
Han C, Zhao R, Liu X, Srivastava A, Gong L, Mao H, Qu M, Zhao W, Yu J, Wang QE. Han C, et al. Mol Cancer Res. 2014 May;12(5):784-94. doi: 10.1158/1541-7786.MCR-13-0638. Epub 2014 Feb 26. Mol Cancer Res. 2014. PMID: 24574518 Free PMC article.
Here, a novel role was identified for DDB2 in the tumorigenesis of ovarian cancer cells and the prognosis of patients with ovarian cancer. Overexpressing DDB2 in human ovarian cancer cells suppressed its capability to recapitulate tumors in athy …
Here, a novel role was identified for DDB2 in the tumorigenesis of ovarian cancer cells and the prognosis of patients with ova …
DDB2 represses epithelial-to-mesenchymal transition and sensitizes pancreatic ductal adenocarcinoma cells to chemotherapy.
Dardare J, Witz A, Betz M, Francois A, Meras M, Lamy L, Lambert A, Grandemange S, Husson M, Rouyer M, Demange J, Merlin JL, Harlé A, Gilson P. Dardare J, et al. Front Oncol. 2022 Dec 8;12:1052163. doi: 10.3389/fonc.2022.1052163. eCollection 2022. Front Oncol. 2022. PMID: 36568213 Free PMC article.
DDB2 has dual roles in several cancers, either as an oncogene or as a tumor suppressor gene, depending on cancer localization. ...Two PDAC cell models with CRISPR-modified DDB2 expression were developed: DDB2 was repressed in DDB2-high T3 …
DDB2 has dual roles in several cancers, either as an oncogene or as a tumor suppressor gene, depending on cancer locali …
Expression of CD44(+)/CD24(-), RAD6 and DDB2 on chemotherapy response in ovarian Cancer: A prospective flow cytometry study.
Sihombing UHM, Andrijono, Purwoto G, Gandamihardja S, Harahap AR, Rustamadji P, Kekalih A, Widyawati R, Fuady DR. Sihombing UHM, et al. Gynecol Oncol Rep. 2022 Jun 3;42:101005. doi: 10.1016/j.gore.2022.101005. eCollection 2022 Aug. Gynecol Oncol Rep. 2022. PMID: 35707599 Free PMC article.
BACKGROUNDS: Ovarian cancer is the 8th deadliest common cancer in women around the world. ...Chemoresistant cancer cells have characteristic expressions of cancer stem cell proteins (CSCs) CD44(+)/CD24(-), RAD6 and DDB2. ...
BACKGROUNDS: Ovarian cancer is the 8th deadliest common cancer in women around the world. ...Chemoresistant cancer cell …
PTEN-negative endometrial cancer cells protect their genome through enhanced DDB2 expression associated with augmented nucleotide excision repair.
Hameed J S F, Devarajan A, M S DP, Bhattacharyya A, Shirude MB, Dutta D, Karmakar P, Mukherjee A. Hameed J S F, et al. BMC Cancer. 2023 May 4;23(1):399. doi: 10.1186/s12885-023-10892-5. BMC Cancer. 2023. PMID: 37142958 Free PMC article.
BACKGROUND: Endometrial cancer (EC) arises from uterine endometrium tissue and is the most prevalent cancer of the female reproductive tract in developed countries. ...RESULTS: The TCGA analyses demonstrated an inverse correlation between the expression of the damag …
BACKGROUND: Endometrial cancer (EC) arises from uterine endometrium tissue and is the most prevalent cancer of the female repr …
The miRNA125a-5p and miRNA125b-1-5p cluster induces cell invasion by down-regulating DDB2-reduced epithelial-to-mesenchymal transition (EMT) in colorectal cancer.
Zhu F, Wei J, He D, He J, Liu L, Hou H, Shi H, Jin S, Li J, Shi X, Liu P, Huang M. Zhu F, et al. J Gastrointest Oncol. 2022 Dec;13(6):3112-3122. doi: 10.21037/jgo-22-1222. J Gastrointest Oncol. 2022. PMID: 36636074 Free PMC article.
A luciferase assay was carried out to confirm the binding site of miRNA-125 and the target gene, damage specific DNA binding protein 2 (DDB2). Western blot was applied to detect the expression levels of DDB2 and the markers of epithelial-to-mesenchymal transition (E …
A luciferase assay was carried out to confirm the binding site of miRNA-125 and the target gene, damage specific DNA binding protein 2 (D …
DDB2 suppresses epithelial-to-mesenchymal transition in colon cancer.
Roy N, Bommi PV, Bhat UG, Bhattacharjee S, Elangovan I, Li J, Patra KC, Kopanja D, Blunier A, Benya R, Bagchi S, Raychaudhuri P. Roy N, et al. Cancer Res. 2013 Jun 15;73(12):3771-82. doi: 10.1158/0008-5472.CAN-12-4069. Epub 2013 Apr 22. Cancer Res. 2013. PMID: 23610444 Free PMC article.
Colon cancer is one of the deadliest cancers worldwide because of its metastasis to other essential organs. ...DDB2 constitutively represses genes that are the key activators of EMT, indicating that DDB2 is a master regulator of EMT of the colon can …
Colon cancer is one of the deadliest cancers worldwide because of its metastasis to other essential organs. ...DDB2 con …
DDB2 Is a Novel Regulator of Wnt Signaling in Colon Cancer.
Huang S, Fantini D, Merrill BJ, Bagchi S, Guzman G, Raychaudhuri P. Huang S, et al. Cancer Res. 2017 Dec 1;77(23):6562-6575. doi: 10.1158/0008-5472.CAN-17-1570. Epub 2017 Oct 11. Cancer Res. 2017. PMID: 29021137 Free PMC article.
Our results identify DDB2 as both a partner and regulator of Wnt signaling, with an important role in suppressing colon cancer development. Cancer Res; 77(23); 6562-75. 2017 AACR....
Our results identify DDB2 as both a partner and regulator of Wnt signaling, with an important role in suppressing colon cancer …
DDB2 regulates DNA replication through PCNA-independent degradation of CDT2.
Wu X, Yu M, Zhang Z, Leng F, Ma Y, Xie N, Lu F. Wu X, et al. Cell Biosci. 2021 Feb 8;11(1):34. doi: 10.1186/s13578-021-00540-5. Cell Biosci. 2021. PMID: 33557942 Free PMC article.
But CDT2 and DDB2 are opposite prognostic factors in kinds of cancers, and the underlining mechanism needs to be elucidated. ...In breast cancer and ovarian teratoma tissues, high level of DDB2 was along with lower level of CDT2. ...
But CDT2 and DDB2 are opposite prognostic factors in kinds of cancers, and the underlining mechanism needs to be elucidated. . …
289 results