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Did you mean del cancer (63,268 results)?
The Complexity of DEK Signaling in Cancer Progression.
Teng Y, Lang L, Jauregui CE. Teng Y, et al. Curr Cancer Drug Targets. 2018;18(3):256-265. doi: 10.2174/1568009617666170522094730. Curr Cancer Drug Targets. 2018. PMID: 28530531 Review.
DEK is increasingly recognized as a crucial player in many steps of cancer initiation and progression, and is precisely regulated by abundant promoting and inhibiting factors directly or indirectly. DEK may serve as an architectural modulating protein to regu …
DEK is increasingly recognized as a crucial player in many steps of cancer initiation and progression, and is precisely regula …
DEK modulates both expression and alternative splicing of cancer-related genes.
Liu B, Sun Y, Zhang Y, Xing Y, Suo J. Liu B, et al. Oncol Rep. 2022 Jun;47(6):111. doi: 10.3892/or.2022.8322. Epub 2022 Apr 27. Oncol Rep. 2022. PMID: 35475534 Free PMC article.
DEK is known to be a potential proto-oncogene and is highly expressed in gastric cancer (GC); thus, DEK is considered to contribute to the malignant progression of GC. ...This study clarified for the first time that DEK has a regulatory effect on the a …
DEK is known to be a potential proto-oncogene and is highly expressed in gastric cancer (GC); thus, DEK is considered t …
DEK is highly expressed in breast cancer and is associated with malignant phenotype and progression.
Yang MQ, Bai LL, Wang Z, Lei L, Zheng YW, Li ZH, Huang WJ, Liu CC, Xu HT. Yang MQ, et al. Oncol Lett. 2021 Jun;21(6):440. doi: 10.3892/ol.2021.12701. Epub 2021 Apr 1. Oncol Lett. 2021. PMID: 33868478 Free PMC article.
DEK proto-oncogene (DEK) has been demonstrated as an oncogene and is associated with the development of many types of tumor; however, the expression and role of DEK in breast cancer remain unknown. ...High DEK expression indicated poor prognosis …
DEK proto-oncogene (DEK) has been demonstrated as an oncogene and is associated with the development of many types of tumor; h …
Role of DEK in carcinogenesis, diagnosis, prognosis, and therapeutic outcome of breast cancer: An evidence-based clinical review.
Habiburrahman M, Sutopo S, Wardoyo MP. Habiburrahman M, et al. Crit Rev Oncol Hematol. 2023 Jan;181:103897. doi: 10.1016/j.critrevonc.2022.103897. Epub 2022 Dec 16. Crit Rev Oncol Hematol. 2023. PMID: 36535490 Review.
Breast cancer is a significantly burdening women's cancer with limited diagnostic modalities. DEK is a novel biomarker overexpressed in breast cancers, currently exhaustively researched for its diagnosis and prognosis. ...
Breast cancer is a significantly burdening women's cancer with limited diagnostic modalities. DEK is a novel biomarker …
Silencing DEK downregulates cervical cancer tumorigenesis and metastasis via the DEK/p-Ser9-GSK-3beta/p-Tyr216-GSK-3beta/beta-catenin axis.
Xu X, Zou L, Yao Q, Zhang Y, Gan L, Tang L. Xu X, et al. Oncol Rep. 2017 Aug;38(2):1035-1042. doi: 10.3892/or.2017.5721. Epub 2017 Jun 14. Oncol Rep. 2017. PMID: 28627610
DEK is reported as an oncogene in various cancers, such as acute myeloid leukemia, bladder cancer, breast cancer and hepatocellular cancer. ...Finally, the xenograft model in nude mice proved that silencing DEK impaired cervical cancer …
DEK is reported as an oncogene in various cancers, such as acute myeloid leukemia, bladder cancer, breast cancer …
The DEK Oncoprotein Functions in Ovarian Cancer Growth and Survival.
Hacker KE, Bolland DE, Tan L, Saha AK, Niknafs YS, Markovitz DM, McLean K. Hacker KE, et al. Neoplasia. 2018 Dec;20(12):1209-1218. doi: 10.1016/j.neo.2018.10.005. Epub 2018 Nov 6. Neoplasia. 2018. PMID: 30412857 Free PMC article.
The chromatin-binding DEK oncoprotein functions in DNA double-strand break repair. We therefore sought to determine the role of DEK in epithelial ovarian cancer. DEK is overexpressed in both primary epithelial ovarian cancers and ovarian canc …
The chromatin-binding DEK oncoprotein functions in DNA double-strand break repair. We therefore sought to determine the role of DE …
DEK-AFF2 Carcinoma of the Sinonasal Region and Skull Base: Detailed Clinicopathologic Characterization of a Distinctive Entity.
Rooper LM, Agaimy A, Dickson BC, Dueber JC, Eberhart CG, Gagan J, Hartmann A, Khararjian A, London NR, MacMillan CM, Palsgrove DN, Nix JS, Sandison A, Stoehr R, Truong T, Weinreb I, Bishop JA. Rooper LM, et al. Am J Surg Pathol. 2021 Dec 1;45(12):1682-1693. doi: 10.1097/PAS.0000000000001741. Am J Surg Pathol. 2021. PMID: 34049316
This study aims to characterize a larger cohort of carcinomas with DEK-AFF2 fusions to assess whether they truly constitute a distinctive entity. ...Overall, the distinctive molecular, histologic, and clinical features of DEK-AFF2 carcinomas suggest they represent a …
This study aims to characterize a larger cohort of carcinomas with DEK-AFF2 fusions to assess whether they truly constitute a distinc …
The PTPN2/PTPN1 inhibitor ABBV-CLS-484 unleashes potent anti-tumour immunity.
Baumgartner CK, Ebrahimi-Nik H, Iracheta-Vellve A, Hamel KM, Olander KE, Davis TGR, McGuire KA, Halvorsen GT, Avila OI, Patel CH, Kim SY, Kammula AV, Muscato AJ, Halliwill K, Geda P, Klinge KL, Xiong Z, Duggan R, Mu L, Yeary MD, Patti JC, Balon TM, Mathew R, Backus C, Kennedy DE, Chen A, Longenecker K, Klahn JT, Hrusch CL, Krishnan N, Hutchins CW, Dunning JP, Bulic M, Tiwari P, Colvin KJ, Chuong CL, Kohnle IC, Rees MG, Boghossian A, Ronan M, Roth JA, Wu MJ, Suermondt JSMT, Knudsen NH, Cheruiyot CK, Sen DR, Griffin GK, Golub TR, El-Bardeesy N, Decker JH, Yang Y, Guffroy M, Fossey S, Trusk P, Sun IM, Liu Y, Qiu W, Sun Q, Paddock MN, Farney EP, Matulenko MA, Beauregard C, Frost JM, Yates KB, Kym PR, Manguso RT. Baumgartner CK, et al. Nature. 2023 Oct;622(7984):850-862. doi: 10.1038/s41586-023-06575-7. Epub 2023 Oct 4. Nature. 2023. PMID: 37794185 Free PMC article.
Immune checkpoint blockade is effective for some patients with cancer, but most are refractory to current immunotherapies and new approaches are needed to overcome resistance(1,2). ...Inhibitors of PTPN2 and PTPN1 offer a promising new strategy for cancer immunother …
Immune checkpoint blockade is effective for some patients with cancer, but most are refractory to current immunotherapies and new app …
Stacking the DEK: from chromatin topology to cancer stem cells.
Privette Vinnedge LM, Kappes F, Nassar N, Wells SI. Privette Vinnedge LM, et al. Cell Cycle. 2013 Jan 1;12(1):51-66. doi: 10.4161/cc.23121. Epub 2012 Dec 19. Cell Cycle. 2013. PMID: 23255114 Free PMC article. Review.
Malignant cells that exhibit stem cell-like activities have been detected in many types of cancers and have been implicated in cancer recurrence and drug resistance. ...As the search continues for markers that distinguish between stem cells, progenitor cells and …
Malignant cells that exhibit stem cell-like activities have been detected in many types of cancers and have been implicated in can …
Dissecting the Potential Interplay of DEK Functions in Inflammation and Cancer.
Pease NA, Wise-Draper T, Privette Vinnedge L. Pease NA, et al. J Oncol. 2015;2015:106517. doi: 10.1155/2015/106517. Epub 2015 Sep 6. J Oncol. 2015. PMID: 26425120 Free PMC article. Review.
Although not entirely understood, these mechanisms include a complex interaction between the immune system and the damaged epithelium that is mediated by an array of molecular signals of inflammation-including reactive oxygen species (ROS), cytokines, and NFkappaB signaling-that …
Although not entirely understood, these mechanisms include a complex interaction between the immune system and the damaged epithelium that i …
354 results