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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2005 1
2011 1
2012 1
2013 1
2014 2
2015 6
2016 3
2017 5
2018 6
2019 5
2021 4
2022 6
2023 8
2024 2

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44 results

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Page 1
KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing.
Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y, Liu Y. Chen J, et al. Nature. 2018 May;557(7706):585-589. doi: 10.1038/s41586-018-0128-9. Epub 2018 May 16. Nature. 2018. PMID: 29769719
Depletion of MEL-26, the Caenorhabditis elegans orthologue of KLHL22, extends worm lifespan. Moreover, KLHL22 levels are elevated in tumours of breast cancer patients, whereas DEPDC5 levels are correspondingly reduced. Depletion of KLHL22 in breast cancer cel …
Depletion of MEL-26, the Caenorhabditis elegans orthologue of KLHL22, extends worm lifespan. Moreover, KLHL22 levels are elevated in tumours …
Dysregulated Amino Acid Sensing Drives Colorectal Cancer Growth and Metabolic Reprogramming Leading to Chemoresistance.
Solanki S, Sanchez K, Ponnusamy V, Kota V, Bell HN, Cho CS, Kowalsky AH, Green M, Lee JH, Shah YM. Solanki S, et al. Gastroenterology. 2023 Mar;164(3):376-391.e13. doi: 10.1053/j.gastro.2022.11.014. Epub 2022 Nov 18. Gastroenterology. 2023. PMID: 36410445 Free PMC article.
BACKGROUND & AIMS: Colorectal cancer (CRC) is a devastating disease that is highly modulated by dietary nutrients. ...We found amino acid-sensing pathways to be essential in the cellular reprogramming of chemoresistance, and chemotherapeutic-resistant patients with col …
BACKGROUND & AIMS: Colorectal cancer (CRC) is a devastating disease that is highly modulated by dietary nutrients. ...We found am …
Genomic Alterations in PIK3CA-Mutated Breast Cancer Result in mTORC1 Activation and Limit the Sensitivity to PI3Kalpha Inhibitors.
Cai Y, Xu G, Wu F, Michelini F, Chan C, Qu X, Selenica P, Ladewig E, Castel P, Cheng Y, Zhao A, Jhaveri K, Toska E, Jimenez M, Jacquet A, Tran-Dien A, Andre F, Chandarlapaty S, Reis-Filho JS, Razavi P, Scaltriti M. Cai Y, et al. Cancer Res. 2021 May 1;81(9):2470-2480. doi: 10.1158/0008-5472.CAN-20-3232. Epub 2021 Mar 8. Cancer Res. 2021. PMID: 33685991 Free PMC article.
Among the top candidates were TSC1, TSC2, TBC1D7, AKT1S1, STK11, MARK2, PDE7A, DEPDC5, NPRL2, NPRL3, C12orf66, SZT2, and ITFG2. Loss of these genes invariably results in sustained mTOR signaling under pharmacologic inhibition of the PI3K-AKT pathway. ...SIGNIFICANCE: These …
Among the top candidates were TSC1, TSC2, TBC1D7, AKT1S1, STK11, MARK2, PDE7A, DEPDC5, NPRL2, NPRL3, C12orf66, SZT2, and ITFG2. Loss …
A Tumor suppressor complex with GAP activity for the Rag GTPases that signal amino acid sufficiency to mTORC1.
Bar-Peled L, Chantranupong L, Cherniack AD, Chen WW, Ottina KA, Grabiner BC, Spear ED, Carter SL, Meyerson M, Sabatini DM. Bar-Peled L, et al. Science. 2013 May 31;340(6136):1100-6. doi: 10.1126/science.1232044. Science. 2013. PMID: 23723238 Free PMC article.
In contrast, inhibition of GATOR2 subunits (Mios, WDR24, WDR59, Seh1L, and Sec13) suppresses mTORC1 signaling, and epistasis analysis shows that GATOR2 negatively regulates DEPDC5. GATOR1 has GTPase-activating protein (GAP) activity for RagA and RagB, and its components ar …
In contrast, inhibition of GATOR2 subunits (Mios, WDR24, WDR59, Seh1L, and Sec13) suppresses mTORC1 signaling, and epistasis analysis shows …
DEPDC5 protects CD8(+) T cells from ferroptosis by limiting mTORC1-mediated purine catabolism.
Li S, Ouyang X, Sun H, Jin J, Chen Y, Li L, Wang Q, He Y, Wang J, Chen T, Zhong Q, Liang Y, Pierre P, Zou Q, Ye Y, Su B. Li S, et al. Cell Discov. 2024 May 20;10(1):53. doi: 10.1038/s41421-024-00682-z. Cell Discov. 2024. PMID: 38763950 Free PMC article.
In this study, we found that epilepsy patients with loss of function mutation of DEPDC5 had reduced peripheral CD8(+) T cells, and DEPDC5 expression positively correlated with tumor-infiltrating CD8(+) T cells as well as overall cancer patient survival, indic …
In this study, we found that epilepsy patients with loss of function mutation of DEPDC5 had reduced peripheral CD8(+) T cells, and …
DEPDC5 deficiency contributes to resistance to leucine starvation via p62 accumulation in hepatocellular carcinoma.
Mizuno Y, Shimada S, Akiyama Y, Watanabe S, Aida T, Ogawa K, Ono H, Mitsunori Y, Ban D, Kudo A, Arii S, Yamaoka S, Tanabe M, Tanaka S. Mizuno Y, et al. Sci Rep. 2018 Jan 8;8(1):106. doi: 10.1038/s41598-017-18323-9. Sci Rep. 2018. PMID: 29311600 Free PMC article.
We herein established hepatocellular carcinoma (HCC) cells knocked out for DEPDC5 by using the CRISPR/Cas9 system, and elucidated that cell viability of the DEPDC5 knockout (DEPDC5-KO) cells was higher than that of the DEPDC5 wild-type (DEPDC5-W …
We herein established hepatocellular carcinoma (HCC) cells knocked out for DEPDC5 by using the CRISPR/Cas9 system, and elucidated tha …
Gentisic acid prevents colorectal cancer metastasis via blocking GPR81-mediated DEPDC5 degradation.
Feng G, Zhang L, Bao W, Ni J, Wang Y, Huang Y, Lyv J, Cao X, Chen T, You K, Khan H, Shen X. Feng G, et al. Phytomedicine. 2024 Jul;129:155615. doi: 10.1016/j.phymed.2024.155615. Epub 2024 Apr 10. Phytomedicine. 2024. PMID: 38615493
PURPOSE: Our study aimed to investigate the effect and mechanism of Gentisic acid on colorectal cancer (CRC) metastasis. STUDY DESIGN: A lung metastasis mouse model induced by tail vein injection and a subcutaneous graft tumor model were used. ...CONCLUSION: CMA-mediated …
PURPOSE: Our study aimed to investigate the effect and mechanism of Gentisic acid on colorectal cancer (CRC) metastasis. STUDY DESIGN …
The genomic landscape across 474 surgically accessible epileptogenic human brain lesions.
López-Rivera JA, Leu C, Macnee M, Khoury J, Hoffmann L, Coras R, Kobow K, Bhattarai N, Pérez-Palma E, Hamer H, Brandner S, Rössler K, Bien CG, Kalbhenn T, Pieper T, Hartlieb T, Butler E, Genovese G, Becker K, Altmüller J, Niestroj LM, Ferguson L, Busch RM, Nürnberg P, Najm I, Blümcke I, Lal D. López-Rivera JA, et al. Brain. 2023 Apr 19;146(4):1342-1356. doi: 10.1093/brain/awac376. Brain. 2023. PMID: 36226386 Free PMC article.
For germline variant-associated malformations of cortical development genes such as TSC2, DEPDC5 and PTEN, germline single-nucleotide variants were frequently identified within large loss of heterozygosity regions, supporting the recently proposed 'second hit' disease mech …
For germline variant-associated malformations of cortical development genes such as TSC2, DEPDC5 and PTEN, germline single-nucleotide …
DEPDC5 variants increase fibrosis progression in Europeans with chronic hepatitis C virus infection.
Burza MA, Motta BM, Mancina RM, Pingitore P, Pirazzi C, Lepore SM, Spagnuolo R, Doldo P, Russo C, Lazzaro V, Fischer J, Berg T, Aghemo A, Cheroni C, De Francesco R, Fargion S, Colombo M, Datz C, Stickel F, Valenti L, Romeo S. Burza MA, et al. Hepatology. 2016 Feb;63(2):418-27. doi: 10.1002/hep.28322. Epub 2015 Dec 18. Hepatology. 2016. PMID: 26517016 Free PMC article.
However, DEPDC5 rs1012068 was independently associated with cirrhosis (n = 300; P = 0.049). ...CONCLUSION: DEPDC5 variants increase fibrosis progression in European subjects with chronic HCV infection. ...
However, DEPDC5 rs1012068 was independently associated with cirrhosis (n = 300; P = 0.049). ...CONCLUSION: DEPDC5 variants inc …
Phosphorylation of DEPDC5, a component of the GATOR1 complex, releases inhibition of mTORC1 and promotes tumor growth.
Padi SKR, Singh N, Bearss JJ, Olive V, Song JH, Cardó-Vila M, Kraft AS, Okumura K. Padi SKR, et al. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20505-20510. doi: 10.1073/pnas.1904774116. Epub 2019 Sep 23. Proc Natl Acad Sci U S A. 2019. PMID: 31548394 Free PMC article.
DEPDC5 phosphorylation by Pim and AKT kinases was confirmed in cancer cells through the use of phospho-specific antibodies and transfection of phospho-inactive DEPDC5 mutants. ...Our results indicate a phosphorylation-dependent regulatory mechanism targeting …
DEPDC5 phosphorylation by Pim and AKT kinases was confirmed in cancer cells through the use of phospho-specific antibodies and …
44 results