Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2010 1
2016 2
2017 1
2018 1
2019 2
2020 3
2021 4
2022 7
2023 3
2024 2

Text availability

Article attribute

Article type

Publication date

Search Results

25 results

Results by year

Filters applied: . Clear all
Page 1
DGKA Provides Platinum Resistance in Ovarian Cancer Through Activation of c-JUN-WEE1 Signaling.
Li J, Pan C, Boese AC, Kang J, Umano AD, Magliocca KR, Yang W, Zhang Y, Lonial S, Jin L, Kang S. Li J, et al. Clin Cancer Res. 2020 Jul 15;26(14):3843-3855. doi: 10.1158/1078-0432.CCR-19-3790. Epub 2020 Apr 27. Clin Cancer Res. 2020. PMID: 32341033 Free PMC article.
Phospho-proteomic and genomic screens were performed to identify downstream effectors of DGKA. Therapeutic efficacy of targeting DGKA was confirmed and clinical relevance of DGKA signaling was validated using ovarian cancer patient-derived tumors that …
Phospho-proteomic and genomic screens were performed to identify downstream effectors of DGKA. Therapeutic efficacy of targeting D …
DGKA Mediates Resistance to PD-1 Blockade.
Fu L, Li S, Xiao W, Yu K, Li S, Yuan S, Shen J, Dong X, Fang Z, Zhang J, Chen S, Li W, You H, Xia X, Kang T, Tan J, Chen G, Yang AK, Gao Y, Zhou P. Fu L, et al. Cancer Immunol Res. 2021 Apr;9(4):371-385. doi: 10.1158/2326-6066.CIR-20-0216. Epub 2021 Feb 19. Cancer Immunol Res. 2021. PMID: 33608256
Dgka inhibition also enhanced the efficacy of anti-PD-1 therapy. We further found that the expression of DGKA in cancer cells promoted tumor growth via the AKT signaling pathway, suggesting that DGKA might be a target in tumor cells as well. ...
Dgka inhibition also enhanced the efficacy of anti-PD-1 therapy. We further found that the expression of DGKA in cancer …
DGKA interacts with SRC/FAK to promote the metastasis of non-small cell lung cancer.
Fu L, Deng R, Huang Y, Yang X, Jiang N, Zhou J, Lin C, Chen S, Wu L, Cui Q, Yun J. Fu L, et al. Cancer Lett. 2022 Apr 28;532:215585. doi: 10.1016/j.canlet.2022.215585. Epub 2022 Feb 4. Cancer Lett. 2022. PMID: 35131384 Free article.
Here, we demonstrated that the expression of diacylglycerol kinase alpha (DGKA) was elevated in the metastatic lesions of non-small cell lung cancer (NSCLC) and correlated with poor survival. ...Pharmacologic ablation of DGKA inhibited the metastasis of NSCLC …
Here, we demonstrated that the expression of diacylglycerol kinase alpha (DGKA) was elevated in the metastatic lesions of non-small c …
Targeting diacylglycerol kinase α impairs lung tumorigenesis by inhibiting cyclin D3.
Zhou D, Liu T, Rao X, Jie X, Chen Y, Wu Z, Deng H, Zhang D, Wang J, Wu G. Zhou D, et al. Thorac Cancer. 2023 May;14(13):1179-1191. doi: 10.1111/1759-7714.14851. Epub 2023 Mar 25. Thorac Cancer. 2023. PMID: 36965165 Free PMC article.
However, it is unclear whether DGKA is linked to the development of lung cancer. METHODS: We investigated the levels of DGKA in the lung cancer tissues. ...The downstream target of DGKA in lung tumorigenesis was identified by RNA sequencing. RES …
However, it is unclear whether DGKA is linked to the development of lung cancer. METHODS: We investigated the levels of DGK …
Decreased LIPF expression is correlated with DGKA and predicts poor outcome of gastric cancer.
Kong Y, Zheng Y, Jia Y, Li P, Wang Y. Kong Y, et al. Oncol Rep. 2016 Oct;36(4):1852-60. doi: 10.3892/or.2016.4989. Epub 2016 Aug 1. Oncol Rep. 2016. PMID: 27498782 Free PMC article.
Gastric cancer (GC) is a common and deadly digestive tract tumor worldwide. ...We then performed immunohistochemistry experiments using gastric tissue arrays to investigate the clinical effects, and the expression of a LIPF target gene, diacylglycerol kinase alpha (DGKA …
Gastric cancer (GC) is a common and deadly digestive tract tumor worldwide. ...We then performed immunohistochemistry experiments usi …
Diacylglycerol Kinase Alpha in Radiation-Induced Fibrosis: Potential as a Predictive Marker or Therapeutic Target.
Liu CS, Schmezer P, Popanda O. Liu CS, et al. Front Oncol. 2020 May 12;10:737. doi: 10.3389/fonc.2020.00737. eCollection 2020. Front Oncol. 2020. PMID: 32477950 Free PMC article. Review.
Radiotherapy is an efficient tool in cancer treatment, but it brings along the risk of side effects such as fibrosis in the irradiated healthy tissue thus limiting tumor control and impairing quality of life of cancer survivors. ...In this review, we scrutinized the …
Radiotherapy is an efficient tool in cancer treatment, but it brings along the risk of side effects such as fibrosis in the irradiate …
Role of Diacylglycerol Kinases in Acute Myeloid Leukemia.
Gravina T, Boggio CMT, Gorla E, Racca L, Polidoro S, Centonze S, Ferrante D, Lunghi M, Graziani A, Corà D, Baldanzi G. Gravina T, et al. Biomedicines. 2023 Jul 1;11(7):1877. doi: 10.3390/biomedicines11071877. Biomedicines. 2023. PMID: 37509516 Free PMC article.
Diacylglycerol kinases (DGKs) play dual roles in cell transformation and immunosurveillance. According to cancer expression databases, acute myeloid leukemia (AML) exhibits significant overexpression of multiple DGK isoforms, including DGKA, DGKD and DGKG, without a …
Diacylglycerol kinases (DGKs) play dual roles in cell transformation and immunosurveillance. According to cancer expression databases …
Therapeutic Targeting of DGKA-Mediated Macropinocytosis Leads to Phospholipid Reprogramming in Tuberous Sclerosis Complex.
Kovalenko A, Sanin A, Kosmas K, Zhang L, Wang J, Akl EW, Giannikou K, Probst CK, Hougard TR, Rue RW, Krymskaya VP, Asara JM, Lam HC, Kwiatkowski DJ, Henske EP, Filippakis H. Kovalenko A, et al. Cancer Res. 2021 Apr 15;81(8):2086-2100. doi: 10.1158/0008-5472.CAN-20-2218. Epub 2021 Feb 16. Cancer Res. 2021. PMID: 33593821 Free PMC article.
DGKA is a lipid kinase that metabolizes diacylglycerol to phosphatidic acid, a key component of plasma membranes. ...In a mouse model of TSC, ritanserin treatment decreased cyst frequency and volume, and in a mouse model of lymphangioleiomyomatosis, genetic downregulation …
DGKA is a lipid kinase that metabolizes diacylglycerol to phosphatidic acid, a key component of plasma membranes. ...In a mouse model …
Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase alpha (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma.
Liu W, Wang H, Zhao Q, Tao C, Qu W, Hou Y, Huang R, Sun Z, Zhu G, Jiang X, Fang Y, Gao J, Wu X, Yang Z, Ping R, Chen J, Yang R, Chu T, Zhou J, Fan J, Tang Z, Yang D, Shi Y. Liu W, et al. Cancer Commun (Lond). 2024 Feb;44(2):226-250. doi: 10.1002/cac2.12513. Epub 2023 Dec 24. Cancer Commun (Lond). 2024. PMID: 38143235 Free PMC article.
Cell proliferation analysis, 5-ethynyl-2'-deoxyuridine (EdU) assay, colony formation assay, RNA-sequencing and Western blotting were performed to investigate the molecular mechanisms of diacylglycerol kinase alpha (DGKA) in iCCA cells. RESULTS: Three metabolic subtypes (S1 …
Cell proliferation analysis, 5-ethynyl-2'-deoxyuridine (EdU) assay, colony formation assay, RNA-sequencing and Western blotting were perform …
25 results