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CircRNF10-DHX15 interaction suppressed breast cancer progression by antagonizing DHX15-NF-kappaB p65 positive feedback loop.
Zheng W, Wang X, Yu Y, Ji C, Fang L. Zheng W, et al. Cell Mol Biol Lett. 2023 Apr 26;28(1):34. doi: 10.1186/s11658-023-00448-7. Cell Mol Biol Lett. 2023. PMID: 37101128 Free PMC article.
On the other hand, NF-kappaB p65 enhanced DHX15 transcription by binding to the promoter of DHX15. Altogether, circRNF10 impaired the DHX15-NF-kappaB p65 positive feedback loop and suppressed the progression of BC. CONCLUSION: CircRNF10-DHX15 interacti …
On the other hand, NF-kappaB p65 enhanced DHX15 transcription by binding to the promoter of DHX15. Altogether, circRNF10 impai …
DHX15 is involved in SUGP1-mediated RNA missplicing by mutant SF3B1 in cancer.
Zhang J, Huang J, Xu K, Xing P, Huang Y, Liu Z, Tong L, Manley JL. Zhang J, et al. Proc Natl Acad Sci U S A. 2022 Dec 6;119(49):e2216712119. doi: 10.1073/pnas.2216712119. Epub 2022 Dec 2. Proc Natl Acad Sci U S A. 2022. PMID: 36459648 Free PMC article.
SF3B1 is the most frequently mutated spliceosomal gene in cancer. Several hotspot mutations are known to disrupt the interaction of SF3B1 with another splicing factor, SUGP1, resulting in the RNA missplicing that characterizes mutant SF3B1 cancers. ...Our data thus …
SF3B1 is the most frequently mutated spliceosomal gene in cancer. Several hotspot mutations are known to disrupt the interaction of S …
Relationship between DHX15 expression and survival in colorectal cancer.
Fan L, Guo X, Zhang J, Wang Y, Wang J, Li Y. Fan L, et al. Rev Esp Enferm Dig. 2023 May;115(5):234-240. doi: 10.17235/reed.2022.8838/2022. Rev Esp Enferm Dig. 2023. PMID: 36177832 Free article.
OBJECTIVE: to explore the relationship between the expression of DEAH-box RNA helicase 15 (DHX15) in colorectal cancer (CRC), its clinical pathological features and survival. METHOD: DHX15 expression data with clinical pathological features from the Cancer …
OBJECTIVE: to explore the relationship between the expression of DEAH-box RNA helicase 15 (DHX15) in colorectal cancer (CRC), …
The RNA helicase Dhx15 mediates Wnt-induced antimicrobial protein expression in Paneth cells.
Wang Y, He K, Sheng B, Lei X, Tao W, Zhu X, Wei Z, Fu R, Wang A, Bai S, Zhang Z, Hong N, Ye C, Tian Y, Wang J, Li M, Zhang K, Li L, Yang H, Li HB, Flavell RA, Zhu S. Wang Y, et al. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2017432118. doi: 10.1073/pnas.2017432118. Proc Natl Acad Sci U S A. 2021. PMID: 33483420 Free PMC article.
However, there is still a lack of in vivo data to support the tissue- or cell-specific function of RNA helicases owing to the lethality of mice with complete knockout of RNA helicases; further, there is a lack of evidence about the antibacterial role of helicases. Here, we invest …
However, there is still a lack of in vivo data to support the tissue- or cell-specific function of RNA helicases owing to the lethality of m …
DHX15 is up-regulated in castration-resistant prostate cancer and required for androgen receptor sensitivity to low DHT concentrations.
Xu Y, Song Q, Pascal LE, Zhong M, Zhou Y, Zhou J, Deng FM, Huang J, Wang Z. Xu Y, et al. Prostate. 2019 May;79(6):657-666. doi: 10.1002/pros.23773. Epub 2019 Feb 3. Prostate. 2019. PMID: 30714180 Free PMC article.
METHODS: We investigated DHX15 expression in castration resistant prostate cancer specimens and the influence of DHX15 on the responsiveness of prostate cancer cells to DHT stimulation. ...RESULTS: The expression level of DHX15 was upregulated i …
METHODS: We investigated DHX15 expression in castration resistant prostate cancer specimens and the influence of DHX15 …
RNA helicase DHX15 exemplifies a unique dependency in acute leukemia.
Guo H, Xu J, Xing P, Li Q, Wang D, Tang C, Palhais B, Roels J, Liu J, Pan S, Huang J, Liu Z, Zhu P, Taghon T, Qing G, Van Vlierberghe P, Liu H. Guo H, et al. Haematologica. 2023 Aug 1;108(8):2029-2043. doi: 10.3324/haematol.2022.282066. Haematologica. 2023. PMID: 36861414 Free PMC article.
We further propose a DHX15 signature modulator drug ciclopirox and demonstrate that it has prominent anti-T-ALL efficacy. Collectively, our data highlight the functional contribution of DHX15 to leukemogenesis through regulation of established oncogenic pathways. .. …
We further propose a DHX15 signature modulator drug ciclopirox and demonstrate that it has prominent anti-T-ALL efficacy. Collectivel …
DHX15 promotes prostate cancer progression by stimulating Siah2-mediated ubiquitination of androgen receptor.
Jing Y, Nguyen MM, Wang D, Pascal LE, Guo W, Xu Y, Ai J, Deng FM, Masoodi KZ, Yu X, Zhang J, Nelson JB, Xia S, Wang Z. Jing Y, et al. Oncogene. 2018 Feb 1;37(5):638-650. doi: 10.1038/onc.2017.371. Epub 2017 Oct 9. Oncogene. 2018. PMID: 28991234 Free PMC article.
DHX15 and Siah2 form a complex with AR, through NES(AR). DHX15 stabilized Siah2 and enhanced its E3 ubiquitin-ligase activity, resulting in AR activation. ...Furthermore, DHX15 immunostaining correlated with Siah2. Finally, DHX15 knockdown inhibited th …
DHX15 and Siah2 form a complex with AR, through NES(AR). DHX15 stabilized Siah2 and enhanced its E3 ubiquitin-ligase activity, …
DHX15 Inhibits Autophagy and the Proliferation of Hepatoma Cells.
Zhao M, Ying L, Wang R, Yao J, Zhu L, Zheng M, Chen Z, Yang Z. Zhao M, et al. Front Med (Lausanne). 2021 Feb 11;7:591736. doi: 10.3389/fmed.2020.591736. eCollection 2020. Front Med (Lausanne). 2021. PMID: 33644083 Free PMC article.
Recently, DHX15 was identified as a tumor-related factor. Although both autophagy and DHX15 are involved in cellular metabolism and cancer progression, their exact relationship and mechanism remain elusive. ...In conclusion, our study demonstrates a non-class …
Recently, DHX15 was identified as a tumor-related factor. Although both autophagy and DHX15 are involved in cellular metabolis …
Phase separation drives RNA virus-induced activation of the NLRP6 inflammasome.
Shen C, Li R, Negro R, Cheng J, Vora SM, Fu TM, Wang A, He K, Andreeva L, Gao P, Tian Z, Flavell RA, Zhu S, Wu H. Shen C, et al. Cell. 2021 Nov 11;184(23):5759-5774.e20. doi: 10.1016/j.cell.2021.09.032. Epub 2021 Oct 21. Cell. 2021. PMID: 34678144 Free PMC article.
Lipoteichoic acid, a known NLRP6 ligand, also promotes NLRP6 LLPS, and DHX15, a helicase in NLRP6-induced interferon signaling, co-forms condensates with NLRP6 and dsRNA. ...
Lipoteichoic acid, a known NLRP6 ligand, also promotes NLRP6 LLPS, and DHX15, a helicase in NLRP6-induced interferon signaling, co-fo …
RNA helicase DHX15 acts as a tumour suppressor in glioma.
Ito S, Koso H, Sakamoto K, Watanabe S. Ito S, et al. Br J Cancer. 2017 Oct 24;117(9):1349-1359. doi: 10.1038/bjc.2017.273. Epub 2017 Aug 22. Br J Cancer. 2017. PMID: 28829764 Free PMC article.
BACKGROUND: Glioblastoma is the most common form of malignant brain cancer and has a poor prognosis in adults. We identified Dhx15 as a candidate tumour suppressor gene in glioma by transposon-based mutagenesis. Dhx15 is an adenosine triphosphate (ATP)-depend …
BACKGROUND: Glioblastoma is the most common form of malignant brain cancer and has a poor prognosis in adults. We identified Dhx15 …
44 results