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DICER1 and Associated Conditions: Identification of At-risk Individuals and Recommended Surveillance Strategies.
Schultz KAP, Williams GM, Kamihara J, Stewart DR, Harris AK, Bauer AJ, Turner J, Shah R, Schneider K, Schneider KW, Carr AG, Harney LA, Baldinger S, Frazier AL, Orbach D, Schneider DT, Malkin D, Dehner LP, Messinger YH, Hill DA. Schultz KAP, et al. Clin Cancer Res. 2018 May 15;24(10):2251-2261. doi: 10.1158/1078-0432.CCR-17-3089. Epub 2018 Jan 17. Clin Cancer Res. 2018. PMID: 29343557 Free PMC article. Review.
Pathogenic germline DICER1 variants cause a hereditary cancer predisposition syndrome with a variety of manifestations. ...Risk for most DICER1-associated neoplasms is highest in early childhood and decreases in adulthood. ...
Pathogenic germline DICER1 variants cause a hereditary cancer predisposition syndrome with a variety of manifestations. ...Ris …
Association between genetic variants in DICER1 and cancer risk: An updated meta-analysis.
Dobrijević Z, Matijašević S, Išić Denčić T, Savić-Pavićević D, Nedić O, Brajušković G. Dobrijević Z, et al. Gene. 2021 Jan 15;766:145132. doi: 10.1016/j.gene.2020.145132. Epub 2020 Sep 8. Gene. 2021. PMID: 32911029 Review.
Due to their potential functional properties, several genetic variants located within DICER1 gene were analyzed for their possible association with the susceptibility to cancer through case-control studies. In order to elucidate their effect on the overall cancer …
Due to their potential functional properties, several genetic variants located within DICER1 gene were analyzed for their possible as …
DICER1 tumor predisposition syndrome: an evolving story initiated with the pleuropulmonary blastoma.
González IA, Stewart DR, Schultz KAP, Field AP, Hill DA, Dehner LP. González IA, et al. Mod Pathol. 2022 Jan;35(1):4-22. doi: 10.1038/s41379-021-00905-8. Epub 2021 Oct 1. Mod Pathol. 2022. PMID: 34599283 Free PMC article. Review.
DICER1 syndrome (OMIM 606241, 601200) is a rare autosomal dominant familial tumor predisposition disorder with a heterozygous DICER1 germline mutation. ...Each of these neoplasms is characterized by a second somatic mutation in DICER1. ...
DICER1 syndrome (OMIM 606241, 601200) is a rare autosomal dominant familial tumor predisposition disorder with a heterozygous DICE …
Circular RNA hsa_circ_0007444 inhibits ovarian cancer progression through miR-23a-3p/DICER1 axis.
Zhang M, Sun Y, Xu H, Shi Y, Shen R, Teng F, Xu J, Jia X. Zhang M, et al. Acta Biochim Biophys Sin (Shanghai). 2023 Apr 13;55(4):574-586. doi: 10.3724/abbs.2023052. Acta Biochim Biophys Sin (Shanghai). 2023. PMID: 37057923 Free PMC article.
Mechanistically, hsa_circ_0007444 can interact with AGO2 and sponge miR-23a-3p, thereby upregulating DICER1 expression, which is an important tumor suppressor in ovarian cancer. And miR-23a-3p mimics can rescue the inhibitory effect of hsa_circ_0007444 on ovarian …
Mechanistically, hsa_circ_0007444 can interact with AGO2 and sponge miR-23a-3p, thereby upregulating DICER1 expression, which is an i …
Biallelic Dicer1 Mutations in the Gynecologic Tract of Mice Drive Lineage-Specific Development of DICER1 Syndrome-Associated Cancer.
Wang Y, Chen SY, Ta M, Senz J, Tao LV, Thornton S, Tamvada N, Yang W, Moscovitz Y, Li E, Guo J, Shen C, Douglas JM, Ei-Naggar AM, Kommoss FKF, Underhill TM, Singh N, Gilks CB, Morin GB, Huntsman DG. Wang Y, et al. Cancer Res. 2023 Nov 1;83(21):3517-3528. doi: 10.1158/0008-5472.CAN-22-3620. Cancer Res. 2023. PMID: 37494476
Here, we developed a genetically engineered conditional compound heterozygous Dicer1 mutant mouse strain that fully recapitulates the biallelic DICER1 mutations in DICER1 syndrome-associated human cancers. ...Thus, this DICER1 syndrome-associate …
Here, we developed a genetically engineered conditional compound heterozygous Dicer1 mutant mouse strain that fully recapitulates the …
Frequency of Pathogenic Germline Variants in Cancer-Susceptibility Genes in the Childhood Cancer Survivor Study.
Kim J, Gianferante M, Karyadi DM, Hartley SW, Frone MN, Luo W, Robison LL, Armstrong GT, Bhatia S, Dean M, Yeager M, Zhu B, Song L, Sampson JN, Yasui Y, Leisenring WM, Brodie SA, de Andrade KC, Fortes FP, Goldstein AM, Khincha PP, Machiela MJ, McMaster ML, Nickerson ML, Oba L, Pemov A, Pinheiro M, Rotunno M, Santiago K, Wegman-Ostrosky T, Diver WR, Teras L, Freedman ND, Hicks BD, Zhu B, Wang M, Jones K, Hutchinson AA, Dagnall C, Savage SA, Tucker MA, Chanock SJ, Morton LM, Stewart DR, Mirabello L. Kim J, et al. JNCI Cancer Spectr. 2021 Jan 23;5(2):pkab007. doi: 10.1093/jncics/pkab007. eCollection 2021 Apr. JNCI Cancer Spectr. 2021. PMID: 34308104 Free PMC article.
The highest frequency of P/LP variants was in genes typically associated with adult onset rather than pediatric cancers, including BRCA1/2, FH, PALB2, PMS2, and CDKN2A. A statistically significant excess of P/LP variants, after correction for multiple tests, was detected i …
The highest frequency of P/LP variants was in genes typically associated with adult onset rather than pediatric cancers, including BR …
DICER1-sarcoma: an emerging entity.
McCluggage WG, Foulkes WD. McCluggage WG, et al. Mod Pathol. 2021 Dec;34(12):2096-2097. doi: 10.1038/s41379-021-00935-2. Epub 2021 Oct 12. Mod Pathol. 2021. PMID: 34642426 Free article. No abstract available.
miRNA processing and human cancer: DICER1 cuts the mustard.
Bahubeshi A, Tischkowitz M, Foulkes WD. Bahubeshi A, et al. Sci Transl Med. 2011 Nov 30;3(111):111ps46. doi: 10.1126/scitranslmed.3002493. Sci Transl Med. 2011. PMID: 22133720 Review.
The identification of neoplasia-associated germline mutations in DICER1 has focused translational research on components of the miRNA processing pathway. Deciphering of the many links between miRNA processing perturbations and cancer will likely provide insights int …
The identification of neoplasia-associated germline mutations in DICER1 has focused translational research on components of the miRNA …
Imaging of DICER1 syndrome.
Guillerman RP, Foulkes WD, Priest JR. Guillerman RP, et al. Pediatr Radiol. 2019 Oct;49(11):1488-1505. doi: 10.1007/s00247-019-04429-x. Epub 2019 Oct 16. Pediatr Radiol. 2019. PMID: 31620849 Review.
DICER1 syndrome is a highly pleiotropic tumor predisposition syndrome that has been increasingly recognized in the last 10 years. ...Radiologists are often the first practitioners to observe these diverse manifestations and play a primary role in recognizing DICER1 …
DICER1 syndrome is a highly pleiotropic tumor predisposition syndrome that has been increasingly recognized in the last 10 years. ... …
Analytical performance of the ThyroSeq v3 genomic classifier for cancer diagnosis in thyroid nodules.
Nikiforova MN, Mercurio S, Wald AI, Barbi de Moura M, Callenberg K, Santana-Santos L, Gooding WE, Yip L, Ferris RL, Nikiforov YE. Nikiforova MN, et al. Cancer. 2018 Apr 15;124(8):1682-1690. doi: 10.1002/cncr.31245. Epub 2018 Jan 18. Cancer. 2018. PMID: 29345728 Free PMC article.
GC cutoffs were established to distinguish cancer from benign nodules with 93.9% sensitivity, 89.4% specificity, and 92.1% accuracy. ...Cancer 2018;124:1682-90. 2018 American Cancer Society....
GC cutoffs were established to distinguish cancer from benign nodules with 93.9% sensitivity, 89.4% specificity, and 92.1% accuracy. …
1,132 results