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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1998 1
1999 2
2000 2
2002 4
2003 8
2004 10
2005 14
2006 14
2007 17
2008 23
2009 28
2010 18
2011 25
2012 25
2013 28
2014 30
2015 22
2016 19
2017 20
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2020 24
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2022 23
2023 11
2024 8

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385 results

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Page 1
Tumor suppressor gene DLC1: Its modifications, interactive molecules, and potential prospects for clinical cancer application.
Ren G, Li G. Ren G, et al. Int J Biol Macromol. 2021 Jul 1;182:264-275. doi: 10.1016/j.ijbiomac.2021.04.022. Epub 2021 Apr 6. Int J Biol Macromol. 2021. PMID: 33836193 Review.
Experimental evidence suggests that direct or indirect targeting of DLC1 is feasible for cancer treatment. Therefore, elucidating the interaction of DLC1 with its binding partners might provide novel targeted therapies for cancer. In this review, we su …
Experimental evidence suggests that direct or indirect targeting of DLC1 is feasible for cancer treatment. Therefore, elucidat …
Functional antagonism between CagA and DLC1 in gastric cancer.
Hinsenkamp I, Köhler JP, Flächsenhaar C, Hitkova I, Meessen SE, Gaiser T, Wieland T, Weiss C, Röcken C, Mowat M, Quante M, Taxauer K, Mejias-Luque R, Gerhard M, Vogelmann R, Meindl-Beinker N, Ebert M, Burgermeister E. Hinsenkamp I, et al. Cell Death Discov. 2022 Aug 13;8(1):358. doi: 10.1038/s41420-022-01134-x. Cell Death Discov. 2022. PMID: 35963849 Free PMC article.
Helicobacter (H.) pylori-induced gastritis is a risk factor for gastric cancer (GC). Deleted-in-liver-cancer-1 (DLC1/ARHGAP7) inhibits RHOA, a downstream mediator of virulence factor cytotoxin-A (CagA) signalling and driver of consensus-molecular-subtype-2 di …
Helicobacter (H.) pylori-induced gastritis is a risk factor for gastric cancer (GC). Deleted-in-liver-cancer-1 (DLC1/AR …
Deleted in liver cancer-1 (DLC1): an emerging metastasis suppressor gene.
Popescu NC, Goodison S. Popescu NC, et al. Mol Diagn Ther. 2014 Jun;18(3):293-302. doi: 10.1007/s40291-014-0086-3. Mol Diagn Ther. 2014. PMID: 24519699 Free PMC article. Review.
Evidence implicating the protein deleted in liver cancer-1 (DLC1), a Rho GTPase activator, in metastasis has accumulated to a point where DLC1 may be considered as a metastasis suppressor gene. This review presents evidence supporting an anti-metastatic role …
Evidence implicating the protein deleted in liver cancer-1 (DLC1), a Rho GTPase activator, in metastasis has accumulated to a …
DLC1 SAM domain-binding peptides inhibit cancer cell growth and migration by inactivating RhoA.
Joshi R, Qin L, Cao X, Zhong S, Voss C, Min W, Li SSC. Joshi R, et al. J Biol Chem. 2020 Jan 10;295(2):645-656. doi: 10.1074/jbc.RA119.011929. Epub 2019 Dec 5. J Biol Chem. 2020. PMID: 31806702 Free PMC article.
Deleted-in-liver cancer 1 (DLC1) exerts its tumor suppressive function mainly through the Rho-GTPase-activating protein (RhoGAP) domain. When activated, the domain promotes the hydrolysis of RhoA-GTP, leading to reduced cell migration. DLC1 is kept in an inac …
Deleted-in-liver cancer 1 (DLC1) exerts its tumor suppressive function mainly through the Rho-GTPase-activating protein (RhoGA …
DLC1 and liver cancer: the Akt connection.
Wuestefeld T, Zender L. Wuestefeld T, et al. Gastroenterology. 2010 Oct;139(4):1093-6. doi: 10.1053/j.gastro.2010.08.016. Epub 2010 Aug 25. Gastroenterology. 2010. PMID: 20800109 No abstract available.
Resveratrol drives cancer cell senescence via enhancing p38MAPK and DLC1 expressions.
Bian Y, Wang X, Zheng Z, Ren G, Zhu H, Qiao M, Li G. Bian Y, et al. Food Funct. 2022 Mar 21;13(6):3283-3293. doi: 10.1039/d1fo02365a. Food Funct. 2022. PMID: 35234761
Pro-senescence therapy is a recently proposed anti-cancer strategy and has been shown to effectively inhibit cancer. Resveratrol is gaining attention for its cancer preventive and suppressive properties. The mechanisms of resveratrol in cancer suppress …
Pro-senescence therapy is a recently proposed anti-cancer strategy and has been shown to effectively inhibit cancer. Resveratr …
Cancer-Associated Point Mutations in the DLC1 Tumor Suppressor and Other Rho-GAPs Occur Frequently and Are Associated with Decreased Function.
Wang D, Qian X, Sanchez-Solana B, Tripathi BK, Durkin ME, Lowy DR. Wang D, et al. Cancer Res. 2020 Sep 1;80(17):3568-3579. doi: 10.1158/0008-5472.CAN-19-3984. Epub 2020 Jun 30. Cancer Res. 2020. PMID: 32606003 Free PMC article.
Here we used the The Cancer Genome Atlas dataset to examine 12 tumor types (including colon, breast, prostate, pancreas, lung adenocarcinoma, and squamous cell carcinoma) for the frequency of codon mutations of 10 Rho-GAP and experimentally tested biochemical and biologica …
Here we used the The Cancer Genome Atlas dataset to examine 12 tumor types (including colon, breast, prostate, pancreas, lung adenoca …
A tumor suppressor DLC1: The functions and signal pathways.
Zhang Y, Li G. Zhang Y, et al. J Cell Physiol. 2020 Jun;235(6):4999-5007. doi: 10.1002/jcp.29402. Epub 2019 Nov 26. J Cell Physiol. 2020. PMID: 31773748 Review.
In many human cancers, the DLC1 expression is frequently downregulated or inactivated, which allows cancer cells to proliferate and disseminate. ...In addition, we explore the clinical data of DLC1 and the mechanisms that natural products upregulate th …
In many human cancers, the DLC1 expression is frequently downregulated or inactivated, which allows cancer cells to pro …
DLC1 as Druggable Target for Specific Subsets of Gastric Cancer: An RNA-seq-Based Study.
Yang L, Bhat AM, Qazi S, Raza K. Yang L, et al. Medicina (Kaunas). 2023 Mar 6;59(3):514. doi: 10.3390/medicina59030514. Medicina (Kaunas). 2023. PMID: 36984515 Free PMC article.
Background: Gastric cancer has been ranked the third leading cause of cancer death worldwide. ...It has a good functional and binding affinity mechanism. Conclusions: Our study revealed that DLC1 could be used as a potential druggable target for specific subs …
Background: Gastric cancer has been ranked the third leading cause of cancer death worldwide. ...It has a good functional and …
DLC1 Is a Prognosis-Related Biomarker Correlated With Tumor Microenvironment Remodeling in Endometrial Carcinoma.
Wu Y, Zheng LE, Chen S, Lv C, Huang Y. Wu Y, et al. Front Oncol. 2022 Feb 11;12:823018. doi: 10.3389/fonc.2022.823018. eCollection 2022. Front Oncol. 2022. PMID: 35223504 Free PMC article.
BACKGROUND AND AIM: Deleted in liver cancer 1 (DLC1) is confirmed as a metastasis suppressor gene in endometrial carcinoma (EC). However, its functional mechanisms remain unclear. This study aimed to explore the relationship between DLC1 expression and EC. ME …
BACKGROUND AND AIM: Deleted in liver cancer 1 (DLC1) is confirmed as a metastasis suppressor gene in endometrial carcinoma (EC …
385 results