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DMXL2 drives epithelial to mesenchymal transition in hormonal therapy resistant breast cancer through Notch hyper-activation.
Faronato M, Nguyen VT, Patten DK, Lombardo Y, Steel JH, Patel N, Woodley L, Shousha S, Pruneri G, Coombes RC, Magnani L. Faronato M, et al. Oncotarget. 2015 Sep 8;6(26):22467-79. doi: 10.18632/oncotarget.4164. Oncotarget. 2015. PMID: 26093085 Free PMC article.
Hence, this warrants the development of reliable indicators of Notch activity. DMXL2 is a novel regulator of Notch signalling not yet investigated in breast cancer. ...These findings identify DMXL2 as a novel, functional biomarker for ERalpha positive breast …
Hence, this warrants the development of reliable indicators of Notch activity. DMXL2 is a novel regulator of Notch signalling not yet …
Identification and validation of hub genes and molecular classifications associated with chronic myeloid leukemia.
Zhong F, Yao F, Xu S, Zhang J, Liu J, Wang X. Zhong F, et al. Front Immunol. 2024 Jan 12;14:1297886. doi: 10.3389/fimmu.2023.1297886. eCollection 2023. Front Immunol. 2024. PMID: 38283355 Free PMC article.
Immune infiltration analysis confirmed the reduced infiltration of immune killer cells such as CD8+ T cells in CML samples. 6 hub genes (LINC01268, NME8, DMXL2, CXXC5, SCD and FBN1) were identified by LASSO regression analysis. ...
Immune infiltration analysis confirmed the reduced infiltration of immune killer cells such as CD8+ T cells in CML samples. 6 hub genes (LIN …
Genomic alterations as independent prognostic factors to predict the type of lung cancer recurrence.
Valter A, Luhari L, Pisarev H, Truumees B, Planken A, Smolander OP, Oselin K. Valter A, et al. Gene. 2023 Nov 15;885:147690. doi: 10.1016/j.gene.2023.147690. Epub 2023 Aug 5. Gene. 2023. PMID: 37544338 Free article.
INTRODUCTION: 33-70% of lung cancer (LC) patients develop recurrence after radical treatment. Previous studies have shown the importance of clinical-pathological characteristics for the risk of recurrence. ...Understanding molecular mechanisms of LC recurrence may lead to …
INTRODUCTION: 33-70% of lung cancer (LC) patients develop recurrence after radical treatment. Previous studies have shown the importa …
Local aromatase excess with recruitment of unusual promoters of CYP19A1 gene in prepubertal patients with gynecomastia.
Deberles E, Durand I, Mittre H, Reznik Y, Morera J. Deberles E, et al. J Pediatr Endocrinol Metab. 2022 Jun 7;35(7):924-930. doi: 10.1515/jpem-2021-0757. Print 2022 Jul 26. J Pediatr Endocrinol Metab. 2022. PMID: 35667691
OBJECTIVES: Gynecomastia may be due to aromatase excess in several diseases such as obesity and cancer. Aromatase excess syndrome (AEXS) is an autosomal dominant disorder caused by overexpression of CYP19A1. ...RESULTS: We observed localized aromatase overexpression (>1 …
OBJECTIVES: Gynecomastia may be due to aromatase excess in several diseases such as obesity and cancer. Aromatase excess syndrome (AE …
Whole-exome sequencing of oral mucosal melanoma reveals mutational profile and therapeutic targets.
Lyu J, Song Z, Chen J, Shepard MJ, Song H, Ren G, Li Z, Guo W, Zhuang Z, Shi Y. Lyu J, et al. J Pathol. 2018 Mar;244(3):358-366. doi: 10.1002/path.5017. Epub 2018 Feb 5. J Pathol. 2018. PMID: 29230811
We identified recurrent mutations involving KIT, POLE, PTPRD, PTCHD2, and DMXL2. Notably, copy number analysis revealed recurrently amplified regions of 12q14 (57.9%, containing CDK4) and 5p15 (47.4%, containing TERT). ...
We identified recurrent mutations involving KIT, POLE, PTPRD, PTCHD2, and DMXL2. Notably, copy number analysis revealed recurrently a …
Short- and long-term effects of radiation exposure at low dose and low dose rate in normal human VH10 fibroblasts.
Akuwudike P, López-Riego M, Marczyk M, Kocibalova Z, Brückner F, Polańska J, Wojcik A, Lundholm L. Akuwudike P, et al. Front Public Health. 2023 Dec 15;11:1297942. doi: 10.3389/fpubh.2023.1297942. eCollection 2023. Front Public Health. 2023. PMID: 38162630 Free PMC article.
RESULTS: The 100 mGy-exposed cells at all abovementioned dose rates, harvested at 0/24 h and 21 days after exposure, showed no strong gene expression changes. DMXL2, involved in the regulation of the NOTCH signaling pathway, presented a consistent upregulation among both t …
RESULTS: The 100 mGy-exposed cells at all abovementioned dose rates, harvested at 0/24 h and 21 days after exposure, showed no strong gene e …
Computational Inferences of the Functions of Alternative/Noncanonical Splice Isoforms Specific to HER2+/ER-/PR- Breast Cancers, a Chromosome 17 C-HPP Study.
Menon R, Panwar B, Eksi R, Kleer C, Guan Y, Omenn GS. Menon R, et al. J Proteome Res. 2015 Sep 4;14(9):3519-29. doi: 10.1021/acs.jproteome.5b00498. Epub 2015 Jul 23. J Proteome Res. 2015. PMID: 26147891 Free PMC article.
We identified 11 alternative splice isoforms that were differentially expressed in HER2+/ER-/PR- BC compared to normal mammary, triple negative breast cancer and triple positive breast cancer tissues (HER2+/ER+/PR+). ...No previous reports link DMXL2 with any …
We identified 11 alternative splice isoforms that were differentially expressed in HER2+/ER-/PR- BC compared to normal mammary, triple negat …