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Clinicopathologic features, tumor immune microenvironment and genomic landscape of Epstein-Barr virus-associated intrahepatic cholangiocarcinoma.
Huang YH, Zhang CZ, Huang QS, Yeong J, Wang F, Yang X, He YF, Zhang XL, Zhang H, Chen SL, Zheng YL, Deng R, Lin CS, Yang MM, Li Y, Jiang C, Kin-Wah Lee T, Ma S, Zeng MS, Yun JP. Huang YH, et al. J Hepatol. 2021 Apr;74(4):838-849. doi: 10.1016/j.jhep.2020.10.037. Epub 2020 Nov 17. J Hepatol. 2021. PMID: 33212090 Free article.
High PD-L1 expression in tumor cells and high CD8+ TIL densities were significantly more common in EBVaICC than in nonEBVaICC. Seven genes (MUC4, DNAH1, GLI2, LIPE, MYH7, RP11-766F14.2 and WDR36) were mutated in at least 3 patients. ...
High PD-L1 expression in tumor cells and high CD8+ TIL densities were significantly more common in EBVaICC than in nonEBVaICC. Seven genes ( …
Identification of hub genes associated with head and neck squamous cell carcinoma by integrated bioinformatics approach and RNA-seq validation analysis.
Shabeer A, Mustafa S, Bukhari RS, Abdel-Maksoud MA, Almutairi SM, Al-Qahtani WH, Chandio K, Khan NY, Gul J, Aufy M. Shabeer A, et al. Am J Cancer Res. 2023 Apr 15;13(4):1259-1277. eCollection 2023. Am J Cancer Res. 2023. PMID: 37168331 Free PMC article.
From these DEGs, prognostic and diagnostic associated four hub genes, which could serve as potential molecular biomarkers and therapeutic targets in HNSC patients were identified. Four hub genes, including down-regulated DNAH1 and DNALI1, while up-regulated DNAH9 and CCDC1 …
From these DEGs, prognostic and diagnostic associated four hub genes, which could serve as potential molecular biomarkers and therapeutic ta …
Somatic mutation of DNAH genes implicated higher chemotherapy response rate in gastric adenocarcinoma patients.
Zhu C, Yang Q, Xu J, Zhao W, Zhang Z, Xu D, Zhang Y, Zhao E, Zhao G. Zhu C, et al. J Transl Med. 2019 Apr 3;17(1):109. doi: 10.1186/s12967-019-1867-6. J Transl Med. 2019. PMID: 30944005 Free PMC article.
In this study, we analyzed the genomic database to evaluate the mutation status of DNAH genes in gastric adenocarcinoma and further identified the significance of mutant DNAH genes as effective molecular biomarkers for predicting chemotherapy response in gastric cancer pat …
In this study, we analyzed the genomic database to evaluate the mutation status of DNAH genes in gastric adenocarcinoma and further identifi …
Genome-wide mutation profiling and related risk signature for prognosis of papillary renal cell carcinoma.
Zhang C, Zheng Y, Li X, Hu X, Qi F, Luo J. Zhang C, et al. Ann Transl Med. 2019 Sep;7(18):427. doi: 10.21037/atm.2019.08.113. Ann Transl Med. 2019. PMID: 31700863 Free PMC article.
METHODS: In this study, we downloaded the simple nucleotide variation data of 288 pRCC samples from The Cancer Genome Atlas (TCGA) database. "GenVisR" package was utilized to visualize gene mutation profiles in pRCC. ...In addition, correlation analysis indicated that 6 mu …
METHODS: In this study, we downloaded the simple nucleotide variation data of 288 pRCC samples from The Cancer Genome Atlas (TCGA) da …
Proteomic identification of potential Clonorchis sinensis excretory/secretory products capable of binding and activating human hepatic stellate cells.
Wang X, Hu F, Hu X, Chen W, Huang Y, Yu X. Wang X, et al. Parasitol Res. 2014 Aug;113(8):3063-71. doi: 10.1007/s00436-014-3972-z. Epub 2014 Jun 4. Parasitol Res. 2014. PMID: 24894083
Nine proteins with abundance change above threefold were Rho GTPase-activating protein, mitochondrial cytochrome c oxidase subunit Va, alpha-enolase, phospholipase C, interleukin-15, insect-derived growth factor, cytochrome c oxidase subunit VI, DNAH1 protein, and kinesin …
Nine proteins with abundance change above threefold were Rho GTPase-activating protein, mitochondrial cytochrome c oxidase subunit Va, alpha …
Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes.
Wang Y, Liu Z, Yang G, Gao Q, Xiao L, Li J, Guo C, Troutwine BR, Gray RS, Xie L, Zhang H. Wang Y, et al. Front Cell Dev Biol. 2020 Nov 4;8:582255. doi: 10.3389/fcell.2020.582255. eCollection 2020. Front Cell Dev Biol. 2020. PMID: 33251213 Free PMC article.
The damaging effects of candidate variants in dynein genes dnali1, dnah1, dnaaf, and zmynd10, as well as in one fibrillin-related gene tns1, were functionally analyzed in zebrafish using targeted CRISPR/Cas9 screening. ...
The damaging effects of candidate variants in dynein genes dnali1, dnah1, dnaaf, and zmynd10, as well as in one fibrillin-related gen …