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DNAH7 mutations benefit colorectal cancer patients receiving immune checkpoint inhibitors.
Yang W, Shen Z, Yang T, Wu M. Yang W, et al. Ann Transl Med. 2022 Dec;10(24):1335. doi: 10.21037/atm-22-6166. Ann Transl Med. 2022. PMID: 36660654 Free PMC article.
This study examined the relationship between ICIs in colorectal cancer and missense mutations in the axonemal dynein heavy chain gene 7 (DNAH7). METHODS: A clinical cohort (n=690) and the CRC data from the publicly available Cancer Genome Atlas (TCGA) were ex …
This study examined the relationship between ICIs in colorectal cancer and missense mutations in the axonemal dynein heavy chain gene …
Whole exome sequencing identifies PLEC, EXO5 and DNAH7 as novel susceptibility genes in testicular cancer.
Paumard-Hernández B, Calvete O, Inglada Pérez L, Tejero H, Al-Shahrour F, Pita G, Barroso A, Carlos Triviño J, Urioste M, Valverde C, González Billalabeitia E, Quiroga V, Francisco Rodríguez Moreno J, Fernández Aramburo A, López C, Maroto P, Sastre J, José Juan Fita M, Duran I, Lorenzo-Lorenzo I, Iranzo P, García Del Muro X, Ros S, Zambrana F, María Autran A, Benítez J. Paumard-Hernández B, et al. Int J Cancer. 2018 Oct 15;143(8):1954-1962. doi: 10.1002/ijc.31604. Epub 2018 Aug 9. Int J Cancer. 2018. PMID: 29761480 Free article.
Therefore, we tried to identify new susceptibility genes responsible for familial testicular cancer that may contribute to increasing our knowledge about the genetic basis of the disease. ...Results were replicated in a second series consisting of 101 TGCTs from the Can …
Therefore, we tried to identify new susceptibility genes responsible for familial testicular cancer that may contribute to increasing …
Recombinant Human Adenovirus Type 5 (H101) Intra-Tumor Therapy in Patients with Persistent, Recurrent, or Metastatic Cervical Cancer: Genomic Profiling Relating to Clinical Efficacy.
Zhang Q, Zhang J, Liu Z, Wang J, Wang F, Wang T, Shi F, Su J, Zhao Y. Zhang Q, et al. Drug Des Devel Ther. 2023 Nov 27;17:3507-3522. doi: 10.2147/DDDT.S429180. eCollection 2023. Drug Des Devel Ther. 2023. PMID: 38046281 Free PMC article.
Here, we evaluated the impact of H101 via exome-sequencing approaches aiming to probe for potential biomarkers that are actionable in the treatment of persistent/recurrent/metastatic (P/R/M) cervical cancer. METHODS: Whole exome sequencing (WES) was performd on paired pre- …
Here, we evaluated the impact of H101 via exome-sequencing approaches aiming to probe for potential biomarkers that are actionable in the tr …
Cross-reactivity of the BRAF VE1 antibody with epitopes in axonemal dyneins leads to staining of cilia.
Jones RT, Abedalthagafi MS, Brahmandam M, Greenfield EA, Hoang MP, Louis DN, Hornick JL, Santagata S. Jones RT, et al. Mod Pathol. 2015 Apr;28(4):596-606. doi: 10.1038/modpathol.2014.150. Epub 2014 Nov 21. Mod Pathol. 2015. PMID: 25412847 Free article.
There is significant sequence homology between the synthetic peptide (amino acid 596-606 of BRAF V600E: GLATEKSRWSG) that was used to generate the VE1 antibody and regions of multiple axonemal dynein heavy chain proteins (eg, DNAH2, DNAH7, and DNAH12). These proteins are m …
There is significant sequence homology between the synthetic peptide (amino acid 596-606 of BRAF V600E: GLATEKSRWSG) that was used to genera …