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Year Number of Results
2005 1
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2012 1
2013 2
2014 3
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2016 8
2017 5
2018 6
2019 6
2020 7
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2022 6
2023 10
2024 1

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66 results

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Page 1
Acetyl-Coenzyme A Synthetase 2 Potentiates Macropinocytosis and Muscle Wasting Through Metabolic Reprogramming in Pancreatic Cancer.
Zhou Z, Ren Y, Yang J, Liu M, Shi X, Luo W, Fung KM, Xu C, Bronze MS, Zhang Y, Houchen CW, Li M. Zhou Z, et al. Gastroenterology. 2022 Nov;163(5):1281-1293.e1. doi: 10.1053/j.gastro.2022.06.058. Epub 2022 Jun 28. Gastroenterology. 2022. PMID: 35777482 Free PMC article.
However, the role of ACSS2 on the nonselective macropinocytosis and cancer cachexia in pancreatic cancer remains elusive. In this study, we demonstrate that ACSS2 potentiates macropinocytosis and muscle wasting through metabolic reprogramming in pancreatic cancer …
However, the role of ACSS2 on the nonselective macropinocytosis and cancer cachexia in pancreatic cancer remains elusive. In t …
The genetic basis of early T-cell precursor acute lymphoblastic leukaemia.
Zhang J, Ding L, Holmfeldt L, Wu G, Heatley SL, Payne-Turner D, Easton J, Chen X, Wang J, Rusch M, Lu C, Chen SC, Wei L, Collins-Underwood JR, Ma J, Roberts KG, Pounds SB, Ulyanov A, Becksfort J, Gupta P, Huether R, Kriwacki RW, Parker M, McGoldrick DJ, Zhao D, Alford D, Espy S, Bobba KC, Song G, Pei D, Cheng C, Roberts S, Barbato MI, Campana D, Coustan-Smith E, Shurtleff SA, Raimondi SC, Kleppe M, Cools J, Shimano KA, Hermiston ML, Doulatov S, Eppert K, Laurenti E, Notta F, Dick JE, Basso G, Hunger SP, Loh ML, Devidas M, Wood B, Winter S, Dunsmore KP, Fulton RS, Fulton LL, Hong X, Harris CC, Dooling DJ, Ochoa K, Johnson KJ, Obenauer JC, Evans WE, Pui CH, Naeve CW, Ley TJ, Mardis ER, Wilson RK, Downing JR, Mullighan CG. Zhang J, et al. Nature. 2012 Jan 11;481(7380):157-63. doi: 10.1038/nature10725. Nature. 2012. PMID: 22237106 Free PMC article.
We also identified new targets of recurrent mutation including DNM2, ECT2L and RELN. The mutational spectrum is similar to myeloid tumours, and moreover, the global transcriptional profile of ETP ALL was similar to that of normal and myeloid leukaemia haematopoietic stem c …
We also identified new targets of recurrent mutation including DNM2, ECT2L and RELN. The mutational spectrum is similar to myeloid tu …
BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes.
Perdreau-Dahl H, Lipsett DB, Frisk M, Kermani F, Carlson CR, Brech A, Shen X, Bergan-Dahl A, Hou Y, Tuomainen T, Tavi P, Jones PP, Lunde M, Wasserstrom JA, Laporte J, Ullrich ND, Christensen G, Morth JP, Louch WE. Perdreau-Dahl H, et al. Circ Res. 2023 May 26;132(11):e188-e205. doi: 10.1161/CIRCRESAHA.122.321732. Epub 2023 May 4. Circ Res. 2023. PMID: 37139790 Free article.
In contrast, the developing heart exhibited declining levels of DNM2. Indeed, we observed that high levels of DNM2 are inhibitory for t-tubule formation, although this protein colocalizes with BIN1 along Z-lines, and binds all 4 isoforms. CONCLUSIONS: These findings …
In contrast, the developing heart exhibited declining levels of DNM2. Indeed, we observed that high levels of DNM2 are inhibit …
Targeting High Dynamin-2 (DNM2) Expression by Restoring Ikaros Function in Acute Lymphoblastic Leukemia.
Ge Z, Gu Y, Han Q, Zhao G, Li M, Li J, Chen B, Sun T, Dovat S, Gale RP, Song C. Ge Z, et al. Sci Rep. 2016 Nov 25;6:38004. doi: 10.1038/srep38004. Sci Rep. 2016. PMID: 27885263 Free PMC article.
However, DNM2 expression in other types of ALL are not reported. We studied DNM2 mRNA level in adults with B- and T-cell ALL. ...We also found Ikaros directly binds the DNM2 promoter and suppresses DNM2 expression. Consequently IKZF1 deletion is associ …
However, DNM2 expression in other types of ALL are not reported. We studied DNM2 mRNA level in adults with B- and T-cell ALL. …
mir-204-5p Acts as a Tumor Suppressor by Targeting DNM2 in Osteosarcoma Cells.
Qu L, Li Z, Liu P. Qu L, et al. J Healthc Eng. 2022 Feb 9;2022:8944588. doi: 10.1155/2022/8944588. eCollection 2022. J Healthc Eng. 2022. PMID: 35186244 Free PMC article. Retracted.
Osteosarcoma is a malignant bone tumor composed of interstitial cells. We aim to seek the function of mir-204-5p/DNM2 in osteosarcoma cells. From April 2017 to August 2019, 58 cases of cancer tissues and paracancer tissues were obtained from patients with osteosarco …
Osteosarcoma is a malignant bone tumor composed of interstitial cells. We aim to seek the function of mir-204-5p/DNM2 in osteosarcoma …
The Role of Mitochondrial Dynamics and Mitotic Fission in Regulating the Cell Cycle in Cancer and Pulmonary Arterial Hypertension: Implications for Dynamin-Related Protein 1 and Mitofusin2 in Hyperproliferative Diseases.
Colpman P, Dasgupta A, Archer SL. Colpman P, et al. Cells. 2023 Jul 20;12(14):1897. doi: 10.3390/cells12141897. Cells. 2023. PMID: 37508561 Free PMC article. Review.
Here we review the role of mitochondrial dynamics in health and disease and discuss emerging concepts in the field, such as the role of central versus peripheral fission and the potential role of dynamin 2 (DNM2) as a fission mediator. In hyperproliferative diseases, such …
Here we review the role of mitochondrial dynamics in health and disease and discuss emerging concepts in the field, such as the role of cent …
Implication of Dynamin-2 (DNM2) Mutations in Adult T-cell Acute Lymphoblastic Leukemia.
Sobh M, Aref S, Al Agdar M, El Zafrany M, El-Sokkary AMA. Sobh M, et al. Asian Pac J Cancer Prev. 2023 Apr 1;24(4):1257-1264. doi: 10.31557/APJCP.2023.24.4.1257. Asian Pac J Cancer Prev. 2023. PMID: 37116148 Free PMC article.
Mutational analysis of DNM2 gene (exons 18 and 22) was performed for all patients using Macrogen 3730 apparatus. ...Active DNM2 mutations were associated with poor clinical outcome. Moreover, high frequency of DNM2 mutations indicated that these mutations cou …
Mutational analysis of DNM2 gene (exons 18 and 22) was performed for all patients using Macrogen 3730 apparatus. ...Active DNM2 …
Caveolin-1 and dynamin-2 overexpression is associated with the progression of bladder cancer.
Raja SA, Shah STA, Tariq A, Bibi N, Sughra K, Yousuf A, Khawaja A, Nawaz M, Mehmood A, Khan MJ, Hussain A. Raja SA, et al. Oncol Lett. 2019 Jul;18(1):219-226. doi: 10.3892/ol.2019.10310. Epub 2019 May 3. Oncol Lett. 2019. PMID: 31289491 Free PMC article.
An increased expression of Cav-1 and DNM2 is known to be associated with the invasive behavior of cancer cells, and with cancer progression. ...The expression patterns of Cav-1 and DNM2 have been previously examined in bladder cancer cell lines, …
An increased expression of Cav-1 and DNM2 is known to be associated with the invasive behavior of cancer cells, and with ca …
A review of Dynamin 2 involvement in cancers highlights a promising therapeutic target.
Trochet D, Bitoun M. Trochet D, et al. J Exp Clin Cancer Res. 2021 Jul 22;40(1):238. doi: 10.1186/s13046-021-02045-y. J Exp Clin Cancer Res. 2021. PMID: 34294140 Free PMC article. Review.
During the last two decades, DNM2 involvement, through mutations or overexpression, emerged in an increasing number of cancers and often associated with poor prognosis. A wide panel of DNM2-dependent processes was described in cancer cells which explai …
During the last two decades, DNM2 involvement, through mutations or overexpression, emerged in an increasing number of cancers …
Dynamins in human diseases: differential requirement of dynamin activity in distinct tissues.
Laiman J, Lin SS, Liu YW. Laiman J, et al. Curr Opin Cell Biol. 2023 Apr;81:102174. doi: 10.1016/j.ceb.2023.102174. Epub 2023 May 23. Curr Opin Cell Biol. 2023. PMID: 37230036 Review.
Dynamin, a 100-kDa GTPase, is one of the most-characterized membrane fission machineries catalyzing vesicle release from plasma membrane during endocytosis. The human genome encodes three dynamins: DNM1, DNM2 and DNM3, with high amino acid similarity but distinct expressio …
Dynamin, a 100-kDa GTPase, is one of the most-characterized membrane fission machineries catalyzing vesicle release from plasma membrane dur …
66 results