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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 3
2000 4
2001 6
2002 19
2003 13
2004 12
2005 15
2006 35
2007 21
2008 28
2009 46
2010 55
2011 90
2012 113
2013 124
2014 168
2015 175
2016 193
2017 209
2018 186
2019 220
2020 227
2021 267
2022 273
2023 260
2024 137

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2,558 results

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Page 1
KMT2C deficiency promotes small cell lung cancer metastasis through DNMT3A-mediated epigenetic reprogramming.
Na F, Pan X, Chen J, Chen X, Wang M, Chi P, You L, Zhang L, Zhong A, Zhao L, Dai S, Zhang M, Wang Y, Wang B, Zheng J, Wang Y, Xu J, Wang J, Wu B, Chen M, Liu H, Xue J, Huang M, Gong Y, Zhu J, Zhou L, Zhang Y, Yu M, Tian P, Fan M, Lu Z, Xue Z, Zhao Y, Yang H, Zhao C, Wang Y, Han J, Yang S, Xie D, Chen L, Zhong Q, Zeng M, Lowe SW, Lu Y, Liu Y, Wei Y, Chen C. Na F, et al. Nat Cancer. 2022 Jun;3(6):753-767. doi: 10.1038/s43018-022-00361-6. Epub 2022 Apr 21. Nat Cancer. 2022. PMID: 35449309 Free PMC article.
Small cell lung cancer (SCLC) is notorious for its early and frequent metastases, which contribute to it as a recalcitrant malignancy. ...Forced DNMT3A expression restrained metastasis of KMT2C-deficient SCLC through repressing metastasis-promoting MEIS/HOX genes. . …
Small cell lung cancer (SCLC) is notorious for its early and frequent metastases, which contribute to it as a recalcitrant malignancy …
DNMT3A in Leukemia.
Brunetti L, Gundry MC, Goodell MA. Brunetti L, et al. Cold Spring Harb Perspect Med. 2017 Feb 1;7(2):a030320. doi: 10.1101/cshperspect.a030320. Cold Spring Harb Perspect Med. 2017. PMID: 28003281 Free PMC article. Review.
DNMT3A is a de novo DNA methyltransferase that has recently gained relevance because of its frequent mutation in a large variety of immature and mature hematologic neoplasms. ...In addition, we review how mutant DNMT3A may contribute to leukemogenesis and the …
DNMT3A is a de novo DNA methyltransferase that has recently gained relevance because of its frequent mutation in a large variety of i …
Downregulation of MEIS1 mediated by ELFN1-AS1/EZH2/DNMT3a axis promotes tumorigenesis and oxaliplatin resistance in colorectal cancer.
Li Y, Gan Y, Liu J, Li J, Zhou Z, Tian R, Sun R, Liu J, Xiao Q, Li Y, Lu P, Peng Y, Peng Y, Shu G, Yin G. Li Y, et al. Signal Transduct Target Ther. 2022 Mar 30;7(1):87. doi: 10.1038/s41392-022-00902-6. Signal Transduct Target Ther. 2022. PMID: 35351858 Free PMC article.
Oxaliplatin is widely used in the frontline treatment of colorectal cancer (CRC), but an estimated 50% of patients will eventually stop responding to treatment due to acquired resistance. ...Mechanistically, oxaliplatin resistance following MEIS1 suppression was critically …
Oxaliplatin is widely used in the frontline treatment of colorectal cancer (CRC), but an estimated 50% of patients will eventually st …
Structural basis for DNMT3A-mediated de novo DNA methylation.
Zhang ZM, Lu R, Wang P, Yu Y, Chen D, Gao L, Liu S, Ji D, Rothbart SB, Wang Y, Wang GG, Song J. Zhang ZM, et al. Nature. 2018 Feb 15;554(7692):387-391. doi: 10.1038/nature25477. Epub 2018 Feb 7. Nature. 2018. PMID: 29414941 Free PMC article.
The DNMT3A-DNA interaction involves a target recognition domain, a catalytic loop, and DNMT3A homodimeric interface. Arg836 of the target recognition domain makes crucial contacts with CpG, ensuring DNMT3A enzymatic preference towards CpG sites in cells. Haem …
The DNMT3A-DNA interaction involves a target recognition domain, a catalytic loop, and DNMT3A homodimeric interface. Arg836 of …
DNMT3a-dermatopontin axis suppresses breast cancer malignancy via inactivating YAP.
Ye D, Wang Y, Deng X, Zhou X, Liu D, Zhou B, Zheng W, Wang X, Fang L. Ye D, et al. Cell Death Dis. 2023 Feb 11;14(2):106. doi: 10.1038/s41419-023-05657-8. Cell Death Dis. 2023. PMID: 36774339 Free PMC article.
Breast cancer (BC) is the most common malignant tumor in women worldwide, and its recurrence and metastasis negatively affect patient prognosis. ...Recently, the influence of dermatopontin (DPT), which is an extracellular matrix protein, has been proposed in the developmen …
Breast cancer (BC) is the most common malignant tumor in women worldwide, and its recurrence and metastasis negatively affect patient …
Clonal hematopoiesis and blood-cancer risk inferred from blood DNA sequence.
Genovese G, Kähler AK, Handsaker RE, Lindberg J, Rose SA, Bakhoum SF, Chambert K, Mick E, Neale BM, Fromer M, Purcell SM, Svantesson O, Landén M, Höglund M, Lehmann S, Gabriel SB, Moran JL, Lander ES, Sullivan PF, Sklar P, Grönberg H, Hultman CM, McCarroll SA. Genovese G, et al. N Engl J Med. 2014 Dec 25;371(26):2477-87. doi: 10.1056/NEJMoa1409405. Epub 2014 Nov 26. N Engl J Med. 2014. PMID: 25426838 Free PMC article.
Early stages in cancer development might be present years before cancers become clinically apparent. ...Detectable clonal expansions most frequently involved somatic mutations in three genes (DNMT3A, ASXL1, and TET2) that have previously been implicated in he …
Early stages in cancer development might be present years before cancers become clinically apparent. ...Detectable clonal expa …
DNMT3A facilitates colorectal cancer progression via regulating DAB2IP mediated MEK/ERK activation.
Zhou Y, Yang Z, Zhang H, Li H, Zhang M, Wang H, Zhang M, Qiu P, Zhang R, Liu J. Zhou Y, et al. Biochim Biophys Acta Mol Basis Dis. 2022 Apr 1;1868(4):166353. doi: 10.1016/j.bbadis.2022.166353. Epub 2022 Jan 19. Biochim Biophys Acta Mol Basis Dis. 2022. PMID: 35063646 Free article.
However, whether DNMT3A can regulate colorectal cancer (CRC) progression via modulation of DAB2IP remains unclear. ...Functionally, ectopic expression of DNMT3A in CRC cells enhanced cell proliferation, whereas DNMT3A knockdown had the opposite effect …
However, whether DNMT3A can regulate colorectal cancer (CRC) progression via modulation of DAB2IP remains unclear. ...Function …
Hematopoietic-specific heterozygous loss of Dnmt3a exacerbates colitis-associated colon cancer.
Feng Y, Yuan Q, Newsome RC, Robinson T, Bowman RL, Zuniga AN, Hall KN, Bernsten CM, Shabashvili DE, Krajcik KI, Gunaratne C, Zaroogian ZJ, Venugopal K, Casellas Roman HL, Levine RL, Chatila WK, Yaeger R, Riva A, Jobin C, Kopinke D, Avram D, Guryanova OA. Feng Y, et al. J Exp Med. 2023 Nov 6;220(11):e20230011. doi: 10.1084/jem.20230011. Epub 2023 Aug 24. J Exp Med. 2023. PMID: 37615936 Free PMC article.
Clonal hematopoiesis (CH) is defined as clonal expansion of mutant hematopoietic stem cells absent diagnosis of a hematologic malignancy. Presence of CH in solid tumor patients, including colon cancer, correlates with shorter survival. We hypothesized that bone marrow-deri …
Clonal hematopoiesis (CH) is defined as clonal expansion of mutant hematopoietic stem cells absent diagnosis of a hematologic malignancy. Pr …
Deleting DNMT3A in CAR T cells prevents exhaustion and enhances antitumor activity.
Prinzing B, Zebley CC, Petersen CT, Fan Y, Anido AA, Yi Z, Nguyen P, Houke H, Bell M, Haydar D, Brown C, Boi SK, Alli S, Crawford JC, Riberdy JM, Park JJ, Zhou S, Velasquez MP, DeRenzo C, Lazzarotto CR, Tsai SQ, Vogel P, Pruett-Miller SM, Langfitt DM, Gottschalk S, Youngblood B, Krenciute G. Prinzing B, et al. Sci Transl Med. 2021 Nov 17;13(620):eabh0272. doi: 10.1126/scitranslmed.abh0272. Epub 2021 Nov 17. Sci Transl Med. 2021. PMID: 34788079 Free PMC article.
Chimeric antigen receptor (CAR) T cell therapy is revolutionizing cancer immunotherapy for patients with B cell malignancies and is now being developed for solid tumors and chronic viral infections. ...The increased functionality of the exhaustion-resistant DNMT3A k …
Chimeric antigen receptor (CAR) T cell therapy is revolutionizing cancer immunotherapy for patients with B cell malignancies and is n …
RNautophagic regulation of DNMT3a-dependent DNA methylation by Linc00942 enhances chemoresistance in gastric cancer.
Zhu L, Zhu Y, Li F, Meng Y, Wang H, Xu W, Luo J, Wang X, Feng L, Jin H. Zhu L, et al. Clin Transl Med. 2023 Jul;13(7):e1337. doi: 10.1002/ctm2.1337. Clin Transl Med. 2023. PMID: 37477089 Free PMC article.
In vitro and in vivo experiments were carried out to testify the effect of DNMT3a on chemoresistance. RESULTS: Autophagy is impaired in chemoresistance which was associated with differential DNA methylation and could be reversed by DNMT3a inhibition. ...Knockdown of …
In vitro and in vivo experiments were carried out to testify the effect of DNMT3a on chemoresistance. RESULTS: Autophagy is impaired …
2,558 results