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1992 1
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2001 6
2002 2
2003 4
2004 1
2005 1
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2007 4
2008 4
2009 3
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2017 3
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117 results

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Page 1
Identification of Core Genes and Pathways in Melanoma Metastasis via Bioinformatics Analysis.
Xie R, Li B, Jia L, Li Y. Xie R, et al. Int J Mol Sci. 2022 Jan 12;23(2):794. doi: 10.3390/ijms23020794. Int J Mol Sci. 2022. PMID: 35054979 Free PMC article.
The upregulated genes were enriched in ECM-receptor interactions and the regulation of actin cytoskeleton, while 365 downregulated genes were enriched in amoebiasis, melanogenesis, and ECM-receptor interactions. The defined hub genes included CDK1, COL17A1, EGFR, DSG1, KRT …
The upregulated genes were enriched in ECM-receptor interactions and the regulation of actin cytoskeleton, while 365 downregulated genes wer …
Epidermal stratification requires retromer-mediated desmoglein-1 recycling.
Hegazy M, Koetsier JL, Huffine AL, Broussard JA, Godsel BM, Cohen-Barak E, Sprecher E, Wolfgeher DJ, Kron SJ, Godsel LM, Green KJ. Hegazy M, et al. Dev Cell. 2022 Dec 19;57(24):2683-2698.e8. doi: 10.1016/j.devcel.2022.11.010. Epub 2022 Dec 9. Dev Cell. 2022. PMID: 36495876 Free PMC article.
Here, we identify an interaction between the retromer endosomal trafficking component, VPS35, and the desmosomal cadherin, desmoglein-1 (Dsg1). Dsg1 is specifically expressed in stratified epidermis and, when properly localized on the plasma membrane of basal kerati …
Here, we identify an interaction between the retromer endosomal trafficking component, VPS35, and the desmosomal cadherin, desmoglein-1 ( …
Detergent exposure induces epithelial barrier dysfunction and eosinophilic inflammation in the esophagus.
Doyle AD, Masuda MY, Pyon GC, Luo H, Putikova A, LeSuer WE, Flashner S, Rank MA, Nakagawa H, Kita H, Wright BL. Doyle AD, et al. Allergy. 2023 Jan;78(1):192-201. doi: 10.1111/all.15457. Epub 2022 Aug 8. Allergy. 2023. PMID: 35899466 Free PMC article.

RESULTS: When EPC2 cells were exposed to SDS (5 mug/ml) for 96 h, TEER decreased (p = 0.03), and FITC-dextran flux increased (p = 0.0002). mRNA expression of IL-33 increased 4.5-fold (p = 0.02) at 6 h and DSG1 decreased (p < 0.0001) by 72 h. Disrupted epithelial integri

…
RESULTS: When EPC2 cells were exposed to SDS (5 mug/ml) for 96 h, TEER decreased (p = 0.03), and FITC-dextran flux increased (p = 0.0002). m …
Expression of DSG1 and DSC1 are prognostic markers in anal carcinoma patients.
Myklebust MP, Fluge Ø, Immervoll H, Skarstein A, Balteskard L, Bruland O, Dahl O. Myklebust MP, et al. Br J Cancer. 2012 Feb 14;106(4):756-62. doi: 10.1038/bjc.2011.548. Br J Cancer. 2012. PMID: 22333708 Free PMC article.
RESULTS: Univariate analyses identified, among others, negative membranous DSG1 staining (P=0.009), negative cytoplasmic DSC1 staining (P=0.012) and negative DSG1 (membranous)+negative DSC1 (cytoplasmic) staining (P=0.004) to be associated with improved cancer …
RESULTS: Univariate analyses identified, among others, negative membranous DSG1 staining (P=0.009), negative cytoplasmic DSC1 stainin …
Keratinocyte cadherin desmoglein 1 controls melanocyte behavior through paracrine signaling.
Arnette CR, Roth-Carter QR, Koetsier JL, Broussard JA, Burks HE, Cheng K, Amadi C, Gerami P, Johnson JL, Green KJ. Arnette CR, et al. Pigment Cell Melanoma Res. 2020 Mar;33(2):305-317. doi: 10.1111/pcmr.12826. Epub 2019 Oct 10. Pigment Cell Melanoma Res. 2020. PMID: 31563153 Free PMC article.
Melanocytes within Dsg1-silenced human skin equivalents exhibited increased pigmentation and altered dendrite morphology, phenotypes which were confirmed in 2D culture using conditioned media from Dsg1-silenced keratinocytes. ...Together with our previous report tha …
Melanocytes within Dsg1-silenced human skin equivalents exhibited increased pigmentation and altered dendrite morphology, phenotypes …
Negative Expression of DSG1 and DSG2, as Prognostic Biomarkers, Impacts on the Overall Survival in Patients with Extrahepatic Cholangiocarcinoma.
Xu S, Huang S, Li D, Zou Q, Yuan Y, Yang Z. Xu S, et al. Anal Cell Pathol (Amst). 2020 Aug 10;2020:9831646. doi: 10.1155/2020/9831646. eCollection 2020. Anal Cell Pathol (Amst). 2020. PMID: 32850288 Free PMC article.
AIMS: To evaluate the expression of DSG1 and DSG2 and investigate their clinicopathological significance in EHCC. ...DSG1 expression was positively correlated with DSG2 expression in EHCC (P < 0.01). ...
AIMS: To evaluate the expression of DSG1 and DSG2 and investigate their clinicopathological significance in EHCC. ...DSG1 expr …
Desmoglein 1 Regulates Invadopodia by Suppressing EGFR/Erk Signaling in an Erbin-Dependent Manner.
Valenzuela-Iglesias A, Burks HE, Arnette CR, Yalamanchili A, Nekrasova O, Godsel LM, Green KJ. Valenzuela-Iglesias A, et al. Mol Cancer Res. 2019 May;17(5):1195-1206. doi: 10.1158/1541-7786.MCR-18-0048. Epub 2019 Jan 17. Mol Cancer Res. 2019. PMID: 30655320 Free PMC article.
Our findings indicate a novel role for Dsg1 in the regulation of invadopodia signaling and provide potential new targets for development of therapies to prevent invadopodia formation and therefore cancer invasion and metastasis. IMPLICATIONS: Our work exposes a new …
Our findings indicate a novel role for Dsg1 in the regulation of invadopodia signaling and provide potential new targets for developm …
Melanoma cells repress Desmoglein 1 in keratinocytes to promote tumor cell migration.
Burks HE, Pokorny JL, Koetsier JL, Roth-Carter QR, Arnette CR, Gerami P, Seykora JT, Johnson JL, Ren Z, Green KJ. Burks HE, et al. J Cell Biol. 2023 Nov 6;222(11):e202212031. doi: 10.1083/jcb.202212031. Epub 2023 Sep 21. J Cell Biol. 2023. PMID: 37733372 Free PMC article.
Melanoma is an aggressive cancer typically arising from transformation of melanocytes residing in the basal layer of the epidermis, where they are in direct contact with surrounding keratinocytes. ...Evidence suggests a model whereby paracrine signaling from melanoma cells …
Melanoma is an aggressive cancer typically arising from transformation of melanocytes residing in the basal layer of the epidermis, w …
Expression of desmogleins 1-3 and their clinical impacts on human lung cancer.
Saaber F, Chen Y, Cui T, Yang L, Mireskandari M, Petersen I. Saaber F, et al. Pathol Res Pract. 2015 Mar;211(3):208-13. doi: 10.1016/j.prp.2014.10.008. Epub 2014 Oct 31. Pathol Res Pract. 2015. PMID: 25468811
Desmosomal proteins have been found dysregulated in various cancers. Here we studied the role of DSGs in human lung cancer. METHODS: Expression of DSG1-3 mRNA in lung cancer cell lines and human bronchial epithelial cells (HBEC) was examined by real ti …
Desmosomal proteins have been found dysregulated in various cancers. Here we studied the role of DSGs in human lung cancer. ME …
Discovery and validation of novel biomarkers for detection of cervical cancer.
Li Z, Chen J, Zhao S, Li Y, Zhou J, Liang J, Tang H. Li Z, et al. Cancer Med. 2021 Mar;10(6):2063-2074. doi: 10.1002/cam4.3799. Epub 2021 Feb 23. Cancer Med. 2021. PMID: 33624385 Free PMC article.
MATERIALS AND METHODS: We collected major datasets of cervical cancer in GEO, and analyzed the differential expression of normal and cancer samples online with GEO2R and tested the differences, then focus on the GSE63514 to screen the target genes in different histo …
MATERIALS AND METHODS: We collected major datasets of cervical cancer in GEO, and analyzed the differential expression of normal and …
117 results