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DUSP2 affects bladder cancer prognosis by down-regulating MEK/ERK and P38 MAPK signaling pathways through PTPN7.
Zou F, Rao T, Chen W, Song T, Li T, Hu W, Li L, Yu W, Cheng F. Zou F, et al. Cell Signal. 2023 Dec;112:110893. doi: 10.1016/j.cellsig.2023.110893. Epub 2023 Sep 20. Cell Signal. 2023. PMID: 37739277
DUSP2 is closely related to the prognosis of cancer, but the role of DUSP2 in bladder cancer is still unclear. This study aims to explore how DUSP2 affects the prognosis of bladder cancer and clarify the important mechanism in bladder …
DUSP2 is closely related to the prognosis of cancer, but the role of DUSP2 in bladder cancer is still unclear. T …
Gastric cancer-derived exosomal miR-519a-3p promotes liver metastasis by inducing intrahepatic M2-like macrophage-mediated angiogenesis.
Qiu S, Xie L, Lu C, Gu C, Xia Y, Lv J, Xuan Z, Fang L, Yang J, Zhang L, Li Z, Wang W, Xu H, Li B, Xu Z. Qiu S, et al. J Exp Clin Cancer Res. 2022 Oct 10;41(1):296. doi: 10.1186/s13046-022-02499-8. J Exp Clin Cancer Res. 2022. PMID: 36217165 Free PMC article.
BACKGROUND: Liver metastasis (LM) is a major obstacle to the prognosis of gastric cancer (GC) patients, but the molecular mechanism underlying gastric cancer liver metastasis (GC-LM) remains unknown. ...Mechanistically, exo-miR-519a-3p activates the MAPK/ERK pathway …
BACKGROUND: Liver metastasis (LM) is a major obstacle to the prognosis of gastric cancer (GC) patients, but the molecular mechanism u …
DUSP2 recruits CSNK2A1 to suppress AKT1-mediated apoptosis resistance under hypoxic microenvironment in pancreatic cancer.
Zhang Y, Kong R, Yang W, Hu K, Zhao Z, Li L, Geng X, Liu L, Chen H, Xiao P, Liu D, Luo Y, Chen H, Hu J, Sun B. Zhang Y, et al. Cancer Lett. 2023 Aug 1;568:216288. doi: 10.1016/j.canlet.2023.216288. Epub 2023 Jun 29. Cancer Lett. 2023. PMID: 37390887
Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxic tumor microenvironment (TME), which aids tumor progression, drug resistance, and immune evasion. Dual-specificity phosphatase 2 (DUSP2), a member of the mitogen-activated protein kinase phosphatase family, …
Pancreatic ductal adenocarcinoma (PDAC) is characterized by hypoxic tumor microenvironment (TME), which aids tumor progression, drug resista …
DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination.
Wang CA, Chang IH, Hou PC, Tai YJ, Li WN, Hsu PL, Wu SR, Chiu WT, Li CF, Shan YS, Tsai SJ. Wang CA, et al. J Extracell Vesicles. 2020 Apr 4;9(1):1746529. doi: 10.1080/20013078.2020.1746529. eCollection 2020. J Extracell Vesicles. 2020. PMID: 32341770 Free PMC article.
EV-VEGF-C exerts paracrine effects on lymphatic endothelial cells and autocrine effects on cancer cells, resulting in the lymphovascular invasion of cancer cells. ...Collectively, these findings represent a conceptual advance in understanding pancreatic cancer …
EV-VEGF-C exerts paracrine effects on lymphatic endothelial cells and autocrine effects on cancer cells, resulting in the lymphovascu …
Loss of DUSP2 predicts a poor prognosis in patients with bladder cancer.
Yin H, He W, Li Y, Xu N, Zhu X, Lin Y, Gou X. Yin H, et al. Hum Pathol. 2019 Mar;85:152-161. doi: 10.1016/j.humpath.2018.11.007. Epub 2018 Nov 17. Hum Pathol. 2019. PMID: 30458195
Currently, whether DUSP2 is involved in pathogenesis of bladder cancer remains unclear. ...Whether DUSP2 functions as a tumor suppressor in bladder cancer deserves further studies....
Currently, whether DUSP2 is involved in pathogenesis of bladder cancer remains unclear. ...Whether DUSP2 functions as a …
The SKA3-DUSP2 Axis Promotes Gastric Cancer Tumorigenesis and Epithelial-Mesenchymal Transition by Activating the MAPK/ERK Pathway.
Zhang C, Zhao S, Tan Y, Pan S, An W, Chen Q, Wang X, Xu H. Zhang C, et al. Front Pharmacol. 2022 Feb 28;13:777612. doi: 10.3389/fphar.2022.777612. eCollection 2022. Front Pharmacol. 2022. PMID: 35295342 Free PMC article.
Mechanistically, SKA3 negative regulates the tumor suppressor DUSP2 and activates the MAPK/ERK pathway to promote gastric cancer. Conclusion: Our results indicate that the SKA3-DUSP2-ERK1/2 axis is involved in the regulation of gastric cancer progressi …
Mechanistically, SKA3 negative regulates the tumor suppressor DUSP2 and activates the MAPK/ERK pathway to promote gastric cancer …
DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway.
Ding S, Gao Y, Lv D, Tao Y, Liu S, Chen C, Huang Z, Zheng S, Hu Y, Chow LK, Wei Y, Feng P, Dai W, Wang X, Xia Y. Ding S, et al. EBioMedicine. 2022 Jul;81:104100. doi: 10.1016/j.ebiom.2022.104100. Epub 2022 Jun 8. EBioMedicine. 2022. PMID: 35689852 Free PMC article.
Upregulation of DNTTIP1 in NPC indicated poor clinical outcomes. Mechanistically, DNTTIP1 suppressed DUSP2 gene expression via recruiting HDAC1 to its promoter and maintaining a deacetylated state of histone H3K27. The downregulation of DUSP2 resulted in aberrant ac …
Upregulation of DNTTIP1 in NPC indicated poor clinical outcomes. Mechanistically, DNTTIP1 suppressed DUSP2 gene expression via recrui …
Differential expression of DUSP2 in left- and right-sided colon cancer is associated with poor prognosis in colorectal cancer.
Dong W, Li N, Pei X, Wu X. Dong W, et al. Oncol Lett. 2018 Apr;15(4):4207-4214. doi: 10.3892/ol.2018.7881. Epub 2018 Jan 26. Oncol Lett. 2018. PMID: 29541187 Free PMC article.
Dual-specificity phosphatase-2 (DUSP2), a negative regulator of extracellular-regulated kinase activity, has been identified as an important kinase with emerging roles in cancer. However, the clinical significance of DUSP2 in colorectal cancer (CRC) re …
Dual-specificity phosphatase-2 (DUSP2), a negative regulator of extracellular-regulated kinase activity, has been identified as an im …
The phosphatase PAC1 acts as a T cell suppressor and attenuates host antitumor immunity.
Dan Lu, Liu L, Sun Y, Song J, Yin Q, Zhang G, Qi F, Hu Z, Yang Z, Zhou Z, Hu Y, Zhang L, Ji J, Zhao X, Jin Y, McNutt MA, Yin Y. Dan Lu, et al. Nat Immunol. 2020 Mar;21(3):287-297. doi: 10.1038/s41590-019-0577-9. Epub 2020 Jan 13. Nat Immunol. 2020. PMID: 31932812
Cancer cells subvert immune surveillance through inhibition of T cell effector function. Elucidation of the mechanism of T cell dysfunction is therefore central to cancer immunotherapy. Here, we report that dual specificity phosphatase 2 (DUSP2; also known as …
Cancer cells subvert immune surveillance through inhibition of T cell effector function. Elucidation of the mechanism of T cell dysfu …
DUSP2 methylation is a candidate biomarker of outcome in head and neck cancer.
Lo Nigro C, Vivenza D, Denaro N, Lattanzio L, Fortunato M, Crook T, Merlano MC. Lo Nigro C, et al. Ann Transl Med. 2018 Jul;6(13):271. doi: 10.21037/atm.2018.06.39. Ann Transl Med. 2018. PMID: 30094257 Free PMC article.
TP53 mutations and epidermal growth factor (EGFR) overexpression are common markers of disease. Dual-specificity-phosphatase-2 (DUSP2) has an essential role in cell proliferation, cancer and immune responses. ...RESULTS: We demonstrate methylation-dependent transcri …
TP53 mutations and epidermal growth factor (EGFR) overexpression are common markers of disease. Dual-specificity-phosphatase-2 (DUSP2 …
77 results